CHR-6494
1333377-65-3
0.98%
2026-08-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName CHR-6494 Cat No CEI-1280 Product Overview Haspin is a serine/threonine kinase that phosphorylates Thr-3 of histone H3 in mitosis that has emerged as a possible cancer therapeutic target. CHR-6494 is a first-in-class Haspin inhibitor with a wide spectrum of anticancer effects. Recent research showed that CHR-6494 reduces H3T3ph levels in a dose-dependent manner and causes a mitotic catastrophe characterized by metaphase misalignment, spindle abnormalities and centrosome amplification. From the cellular standpoint, the identified small-molecule Haspin inhibitor causes arrest in G2/M and subsequently apoptosis. Importantly, ex vivo assays also demonstrate its anti-angiogenetic features; in vivo, it shows antitumor potential in xenografted nude mice without any observed toxicity. CAS No 1333377-65-3 Molecular Weight 292.34 Purity 0.98 Storage Store at -20°C Synonyms CHR 6494; CHR6494 Targets Haspin Molecular Formula C16H16N6 Chemical Name 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 1333377-65-3 Basic Info-
Product Name:
CHR-6494
Other Name:3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;CHR-6494 3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;3-(1H-Indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;CHR 6494 trifluoroacetate salt;CHR-6494 trifluoroacetate salt;Haspin Kinase Inhibitor, CHR-6494;CHR-6494
CAS No.:1333377-65-3
Molecular Formula:C16H16N6
InChIKeys:CZZCAOGIEGXMBZ-UHFFFAOYSA-N
Molecular Weight:292.33844
Exact Mass:292.143646
DSSTox ID:DTXSID90742629
Categories:
Characteristics-
PSA:
70.9
XLogP3:2.48
Appearance:white to beige
Density:1.39±0.1 g/cm3(Predicted)
Refractive Index:1.747
Water Solubility:DMSO: soluble5mg/mL, clear (warmed)
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product