CHR-6494
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CHR-6494
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CAS No:
1333377-65-3
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Formula:
C16H16N6
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Chemical Name:
CHR-6494
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Synonyms:
3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;CHR-6494 3-(1H-indazol-5-yl)-N-propyliMidazo[1,2-b]pyridazin-6-aMine;3-(1H-Indazol-5-yl)-N-propyl-imidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;3-(1H-Indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine trifluoroacetate salt;CHR 6494 trifluoroacetate salt;CHR-6494 trifluoroacetate salt;Haspin Kinase Inhibitor, CHR-6494;CHR-6494
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CAS No:
Description
CHR-6494 is a potent inhibitor of haspin, inhibiting histone H3T3 phosphorylation, with an IC50 of 2 nM.
Characteristics
70.9
2.48
white to beige
1.39±0.1 g/cm3(Predicted)
1.747
DMSO: soluble5mg/mL, clear (warmed)
2-8°C
Computed Properties
Molecular Weight:292.34
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:292.14364454
Monoisotopic Mass:292.14364454
Topological Polar Surface Area:70.9
Heavy Atom Count:22
Complexity:378
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes
