M344
251456-60-7
98%
Yes
2026-11-11
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName M344 Cat No CEI-0509 Description An amide analog of Trichostatin A that potently Inhibits histone deacetylases (IC50 = 40 nM for rat liver HDAC and IC50 = 100 nM for maize HDAC). Induces differentiation and inhibits proliferation (~2 µM) of murine erythroleukemia cells. Appearance Liquid Product Overview A HDAC inhibitor CAS No 251456-60-7 Molecular Weight 544.43 Purity >98% by HPLC Storage -20 centigrade Targets HDAC Molecular Formula C₁₆H₂₅N₃O₃ Chemical Name 4-Dimethylamino-N-(6-hydroxycarbamoyl-hexyl)-benzamide Shipping Conditions Gel pack category Inhibitors(c1514) cas_num 251456-60-7 ECHEMI Editorial ReferenceM344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.
4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.|A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.Basic Info-
Product Name:
M344
Other Name:M344;HISTONE DEACETYLASE INHIBITOR III;4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE;N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide,MS344,D237,N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS344;4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
CAS No.:251456-60-7
Molecular Formula:C16H25N3O3
InChIKeys:MXWDSZWTBOCWBK-UHFFFAOYSA-N
Molecular Weight:307.39
Exact Mass:307.189606
NSC Number:718169
DSSTox ID:DTXSID90274415
Categories:
Characteristics-
PSA:
81.7
XLogP3:1.7
Appearance:white to beige
Density:1.1±0.1 g/cm3
Melting Point:161℃
Refractive Index:1.558
Water Solubility:DMSO: soluble10mg/mL, clear
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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