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M344

M344 structure

CAS No:
251456-60-7
Formula:
C16H25N3O3
Chemical Name:
M344
Synonyms:
M344;HISTONE DEACETYLASE INHIBITOR III;4-DIMETHYLAMINO-N-(6-HYDROXYCARBAMOYLHEXYL)-BENZAMIDE;N-HYDROXY-7-(4-DIMETHYLAMINOBENZOYL)AMINOHEPTANAMIDE;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide,MS344,D237,N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide;4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide;MS344;4-(Diethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide
Categories:
Biochemical Engineering > Inhibitors

Description

M344 (D 237) is an inhibitor of histone deacetylase (IC50=100 nM) and an inducer of terminal cell fifferentiation.

4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide is a benzamide resulting from the formal condensation of the carboxy group of 4-(dimethylamino)benzoic acid with the amino group of 7-amino-N-hydroxyheptanamide. It is a potent inhibitor of histone deacetylases and induces cell cycle arrest and apoptosis in several human cancer cell lines. It has a role as an apoptosis inducer, an antineoplastic agent and an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a member of benzamides, a hydroxamic acid, a secondary carboxamide and a tertiary amino compound.|A hydroxamic acid and anilide derivative that acts as a HISTONE DEACETYLASE inhibitor. It is used in the treatment of CUTANEOUS T-CELL LYMPHOMA and SEZARY SYNDROME.

M344 Basic Attributes

Molecular Weight：

307.39

Exact Mass：

307.189606

NSC Number：

718169

DSSTox ID：

DTXSID90274415

Characteristics

PSA：

81.7

XLogP3：

1.7

Appearance：

white to beige

Density：

1.1±0.1 g/cm3

Melting Point：

161℃

Refractive Index：

1.558

Water Solubility：

DMSO: soluble10mg/mL, clear

Storage Conditions：

2-8°C

Safety Information

Transport codes：

NONH for all modes of transport

wgk germany：

Drug Information

MeSH：

Substances that inhibit or prevent the proliferation of NEOPLASMS. (See all compounds classified as Antineoplastic Agents.)|Compounds that inhibit HISTONE DEACETYLASES. This class of drugs may influence gene expression by increasing the level of acetylated HISTONES in specific CHROMATIN domains. (See all compounds classified as Histone Deacetylase Inhibitors.)

MeSH Entry Terms：

18F Suberoylanilide Hydroxamic Acid

M344 Use and Manufacturing

M 344 is an inhibitor of histone deacetylases (HDACs), inhibiting maize HDAC (IC50 = 100 nM) as well as human HDAC1 (IC50 = 46 nM). It shows a three-fold selectivity for inhibition of HDAC6 over HDAC1. M 344 enhances the sensitivity of human squamous carcinoma cells to radiation and promotes cell cycle arrest and apoptosis in human endometrial cancer and ovarian cancer cells (ED50 = 2.3 μM).

Computed Properties

Molecular Weight:307.39
XLogP3:1.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:9
Exact Mass:307.18959167
Monoisotopic Mass:307.18959167
Topological Polar Surface Area:81.7
Heavy Atom Count:22
Complexity:340
Covalently-Bonded Unit Count:1
Compound Is Canonicalized:Yes

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M344

CAS No.: 251456-60-7

Content: 98%

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