Etodolac
41340-25-4
0.98%
2026-07-03
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Etodolac Cat No CEI-1331 Product Overview Etodolac (Lodine) is a selective Cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 53.5 nM. Etodolac, a non-steroidal anti-inflammatory drug (NSAID), has been reported to treat osteoarthritis and rheumatoid arthritis. Etodolac was able to abolish the cell size decrease and block caspase-3/7 activity in TNFα-induced isolated rabbit articular chondrocytes. However, studies have shown that etodolac at 24h could induce cell death in human malignant rhabdoid tumor cells (FRTK-1) in a dose-dependent manner. Additionally, etodolac has shown to increase caspase-8,-9 and-3 activity 3 at 24 or 48 h in FRTK-1. CAS No 41340-25-4 Molecular Weight 287.35 Purity 0.98 Storage Store at-20°C Targets COX-2 Molecular Formula C17H21NO3 Chemical Name 2-(1,8-diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Antipyretic Analgesics(c1413) cas_num 41340-25-4 Basic Info-
Product Name:
Etodolac
Other Name:Pyrano[3,4-b]indole-1-acetic acid,1,8-diethyl-1,3,4,9-tetrahydro-;1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid;Etodolic acid;AY 24236;Etodolac;NIH 9918;(±)-Etodolac;(RS)-Etodolic acid;Lodine;Zedolac;Ultradol;Tedolan;Ramodar;Edolan;NSC 282126;Etogesic;Lodin XL;Napilac;Etodine;Eccoxolac;1,8-Diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-acetic acid;Flancox;Etopan;2-(1,8-Diethyl-4,9-dihydro-3H-pyrano[3,4-b]indol-1-yl)acetic acid;87226-38-8
CAS No.:41340-25-4
Molecular Formula:C17H21NO3
InChIKeys:InChIKey=NNYBQONXHNTVIJ-UHFFFAOYSA-N
Molecular Weight:287.35
Exact Mass:287.35
EC Number:1312995-182-4
NSC Number:757821|282126
DSSTox ID:DTXSID9020615
ATC Code:M - Musculo-skeletal system
HScode:2934999090
Categories:
Characteristics-
PSA:
62.3
XLogP3:2.8
Appearance:crystalline solid
Density:1.2±0.1 g/cm3
Melting Point:146.5 °C
Boiling Point:507.9ºC at 760 mmHg
Flash Point:261.0±28.7 °C
Refractive Index:1.597
Water Solubility:40mg/L(37 ºC)
Storage Conditions:2-8°C
Dissociation Constants:4.65
Collision Cross Section:164.4 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Eye irritation, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H319 Causes serious eye irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product