AAL-993
269390-77-4
98%
2026-07-22
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName AAL-993 Cat No CEI-0953 Description A potent and selective inhibitor of VEGFR-1 (IC50=130nM), VEGFR-2 (IC50=23nM) and VEGFR-3 (IC50=18nM). At higher concentrations it inhibits PDGFR (640nM), c-Kit (236nM) and CSF-1R (380nM). Inactive at other kinases such as EGFR, FGFR-1, CDK-1, Tie-2, c-Met, IGF-1R, c-Src and c-Abl. X-ray crystal studies on AAL-993 complexed to the catalytic domain of diphosphorylated VEGFR- 2 indicates that it binds to an inactive conformation of the protein. Cell permeable and active in vivo. Inhibits VEGF-induced angiogenesis (mouse model) (1). Abbr AAL-993(VEGFA) Alias 2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide Appearance Light yellow powder Product Overview VEGF inhibitor CAS No 269390-77-4 Molecular Weight 371.1 Purity >98% (TLC); NMR (Conforms) Synonyms 2-((4-Pyridyl)methyl)amino-N-(3 (trifluoromethyl)phenyl)benzamide Targets VEGF Molecular Formula C20H16F3N3O Solubility May be dissolved in DMSO (>25 mg/ml); or Ethanol (15 mg/ml) category Specialty Chemicals(c26) cas_num 269390-77-4 Basic Info-
Product Name:
AAL-993
Other Name:AAL-993;CS-2315;2-[(4-Pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]benzami de;VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 - CAS 269390-77-4 - Calbiochem;2-(Pyridin-4-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]benzamide;Benzamide, 2-[(4-pyridinylmethyl)amino]-N-[3-(trifluoromethyl)phenyl]-
CAS No.:269390-77-4
Molecular Formula:C20H16F3N3O
InChIKeys:BLAFVGLBBOPRLP-UHFFFAOYSA-N
Molecular Weight:371.36
Exact Mass:371.12454663
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Characteristics-
Density:
1.349±0.06 g/cm3
Melting Point:158-160 °C
Boiling Point:441.3±45.0 °C(Predicted)
PKA:12.95±0.70
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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