MK-5172 sodium salt
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CAS No.:
1425038-27-2
Price valid (until):
2026-07-04
Company Type:
Manufactory
Location:
United States
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Description
ProductName MK-5172 sodium salt Cat No CEI-1430 Product Overview IC50 Value: 7.4nM and 7nM for genotype1b and 1a respectively, in replicon system. MK-5172 is a novel P2-P4 quinoxaline macrocyclic HCV NS3/4a protease inhibitor currently in clinical development. Clinical trial: Evaluation of Hepatic Pharmacokinetics for MK-5172 in Participants With Chronic Hepatitis C. Phase1 CAS No 1425038-27-2 Molecular Weight 789.89 Storage Store at -20°C Synonyms MK5172 sodium salt; MK 5172 sodium salt Targets HCV NS3/4a protease Molecular Formula C38H50N6NaO9S+ Solubility Soluble in DMSO Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro In biochemical assays, MK-5172 was effective against a panel of major genotypes and variants engineered with common resistant mutations observed in clinical studies with other NS3/4a protease inhibitors. In the replicon assay, MK-5172 demonstrated subnanomolar to low-nanomolar EC50s against genotypes 1a, 1b, and 2a. In vivo In rats, MK-5172 showed a plasma clearance of 28 ml/min/kg and plasma half-life of 1.4 hr. When dosed p. o. at 5 mg/kg, the plasma exposure of MK-5172 was good with an AUC of 0.7 uM. hr. The liver exposure of the compound was quite good (23 uM at 4 hr), and MK-5172 remained in liver 24 hr after a single p. o. 5 mg/kg dose. At 24 hr, the liver concentration of MK-5172 was 0.2 uM, which was over 25-fold higher than the IC50 in the replicon assay with 50% NHS. When dosed to dogs, MK-5172 showed low clearance of 5 ml/min/kg and a 3 hr half-life after i. v. 2 mg/kg dosing and had good plasma exposure (AUC=0.4 uM. hr) after a p. o. 1 mg/kg dose. category Specialty Chemicals(c26) cas_num 1425038-27-2 Basic Info-
Product Name:
Grazoprevir sodium
CAS No.:1425038-27-2
Categories:
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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