JAK3 Inhibitor IV
58753-54-1
99%
2026-07-23
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName JAK3 Inhibitor IV Cat No CEI-1064 Description A (β-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25centigrade, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1]. Abbr JAK3 Inhibitor IV(JAK3, JAK1, EGFR) Alias JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK CAS No 58753-54-1 Molecular Weight 367.9 Purity >99% by HPLC Storage -20 centigrade Synonyms JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK Targets JAK-3, JAK-1, EGF-R Molecular Formula C23H25NO · HCl Chemical Name 2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923 Solubility DMSO category Specialty Chemicals(c26) cas_num 58753-54-1 Basic Info-
Product Name:
ZM39923HYDROCHLORIDE
Other Name:JAK3 INHIBITOR IV;ZM 39923;ZM 39923 HYDROCHLORIDE;ZM39923HCl;2-NAPHTHYL-(N-ISOPROPYL,N-BENZYL)-BETA-AMINOETHYLKETONE, HCL;3-(N-BENZYL-N-ISOPROPYL)AMINO-1-(NAPHTHALEN-2-YL)PROPAN-1-ONE HYDROCHLORIDE;3-BENZYLISOPROPYLAMINO-1-NAPHTHALEN-2-YL-PROPAN-1-ONE HYDROCHLORIDE;2-Naphthyl-(n-isopropyl,n-benzyl)-beta-aminoethylketone
CAS No.:58753-54-1
Molecular Formula:C16H19NO
InChIKeys:NJTUORMLOPXPBY-UHFFFAOYSA-N
Molecular Weight:241.33
Exact Mass:367.1702921 g/mol
DSSTox ID:DTXSID70207488
Categories:
Characteristics-
PSA:
20.3 Ų
Density:1.047±0.06 g/cm3
Melting Point:151-154 °C(lit.)
Boiling Point:397.4±25.0 °C(Predicted)
PKA:9.50±0.29
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product