Cucurbitacin I
2222-07-3
98%
2026-07-01
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Cucurbitacin I Cat No CEI-1077 Description Selective inhibitor of STAT3/JAK2 signaling. Inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Suppresses phosphotyrosine levels of STAT3, inhibits STAT3 DNA binding and STAT3-mediated gene expression. Induces apoptosis in cell lines expressing constitutively active tyrosine-phosphorylated STAT3. Abbr Cucurbitacin I(STAT3, JAK2) Alias APRF, HIES CAS No 2222-07-3 Molecular Weight 514.65 Purity >98 % Stability Stable under recommended storage conditions. Storage -20 centigrade Synonyms APRF, HIES Targets STAT3, JAK2 Molecular Formula C30H42O7 Chemical Name (9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione Solubility Soluble to 10 mM in DMSO and to 20 mM in ethanol category Plant Extracts(c1524) cas_num 2222-07-3 Basic Info-
Product Name:
Cucurbitacin I
Other Name:19-Norlanosta-1,5,23-triene-3,11,22-trione,2,16,20,25-tetrahydroxy-9-methyl-,(9β,10α,16α,23E)-;19-Nor-9β,10α-lanosta-1,5,23-triene-3,11,22-trione,2,16α,20,25-tetrahydroxy-9-methyl-;Elatericin B;(9β,10α,16α,23E)-2,16,20,25-Tetrahydroxy-9-methyl-19-norlanosta-1,5,23-triene-3,11,22-trione;Cucurbitacin I;NSC 521777;JSI 124;204376-97-6
CAS No.:2222-07-3
Molecular Formula:C30H42O7
InChIKeys:InChIKey=NISPVUDLMHQFRQ-MKIKIEMVSA-N
Molecular Weight:514.65
Exact Mass:514.65
EC Number:218-736-8
UNII:SHQ47990PH
NSC Number:521777|112167
Categories:
Characteristics-
PSA:
132.13000
XLogP3:2.06
Density:1.3±0.1 g/cm3
Melting Point:148-150°C
Boiling Point:716.9±60.0 °C at 760 mmHg
Flash Point:401.3±29.4 °C
Refractive Index:1.594
Storage Conditions:−20°C
Toxicity:LD50 oral in mouse: 5mg/kg
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 3, Dermal
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H311 Toxic in contact with skin
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product