TPCA-1
507475-17-4
0.98%
2026-08-02
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName TPCA-1 Cat No CEI-1559 Description TPCA-1 is a selective inhibitor of IκB kinase-2 with IC50 values of 17.9 nM and 0.4 μM for IKK-2 and-1, respectively. Product Overview TPCA-1 is a novel, potent, and selective inhibitor of human IKK-2.Demonstration that IκB kinase 2 (IKK-2) plays a pivotal role in the nuclear factor-κB-regulated production of proinflammatory molecules by stimuli such as tumor necrosis factor (TNF)-α and interleukin (IL)-1 suggests that inhibition of IKK-2 may be beneficial in the treatment of rheumatoid arthritis. CAS No 507475-17-4 Molecular Weight 279.29 Purity 0.98 Storage Desiccate at-20°C Targets IKK-2 IC50 17.9 nM; 0.4 μM Molecular Formula C12H10FN3O2S Chemical Name 2-(carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request In vitro Determination of the activity of TPCA-1 against ten selected kinases, COX-1 and COX-2, showed the compound to be ~550-fold selective for IKK-2 versus ten of these enzymes. TPCA-1 inhibits lipopolysaccharide-induced human monocyte production of TNF-α, IL-6, and IL-8 with an IC50 of 170 to 320 nM. In vivo Prophylactic administration of TPCA-1 at 3, 10, or 20 mg/kg resulted in a dose dependent reduction in the severity of murine collagen-induced arthritis. The significantly reduced disease severity and delay of disease onset resulting from administration of TPCA-1 at 10 mg/kg were comparable to the effects of the antirheumatic drug, etanercept. category Inhibitors(c1514) cas_num 507475-17-4 Basic Info-
Product Name:
TPCA-1
Other Name:TPCA-1;2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide;TPCA-1(TPCA 1);3-ThiophenecarboxaMide, 2-[(aMinocarbonyl)aMino]-5-(4-fluorophenyl)-;5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide TPCA-1;TPCA-1 IKK-2 Inhibitor IV;GW683965
CAS No.:507475-17-4
Molecular Formula:C12H10FN3O2S
InChIKeys:SAYGKHKXGCPTLX-UHFFFAOYSA-N
Molecular Weight:279.294
Exact Mass:279.047760
Categories:
Characteristics-
PSA:
126
XLogP3:1.7
Appearance:white to light brown
Density:1.5±0.1 g/cm3
Boiling Point:442.576°C at 760 mmHg
Flash Point:221.5±28.7 °C
Refractive Index:1.686
Water Solubility:DMSO: soluble5mg/mL, clear
Storage Conditions:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Eye irritation, Category 2
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H319 Causes serious eye irritation
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product