Teniposide
29767-20-2
99%
2026-07-22
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Teniposide Cat No CEI-0365 Description Teniposide is a chemotherapeutic medication mainly used in the treatment of childhood acute lymphocytic leukemia (ALL). It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body. Teniposide causes dose-dependent single- and double-stranded breaks in DNA and DNA-protein cross-links. The mechanism of action appears to be related to the inhibition of type II topoisomerase activity since teniposide does not intercalate into DNA or bind strongly to DNA. Alias Vumon CAS No 29767-20-2 Molecular Weight 656.65 Purity >99% Storage 2 years at -20 centigrade Synonyms Vumon Targets Topoisomerase II Molecular Formula C32H32O13S Solubility DMSO 40 mg/mL, Water category Antineoplastic Agents(c1417) cas_num 29767-20-2 Basic Info-
Product Name:
Teniposide
Other Name:Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]-,(5R,5aR,8aR,9S)-;Epipodophyllotoxin,4′-demethyl-,9-(4,6-O-2-thenylidene-β-D-glucopyranoside);Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-β-D-glucopyranosyl]oxy]-,[5R-[5α,5aβ,8aα,9β(R*)]]-;Pyrano[3,2-d]-1,3-dioxin,furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one deriv.;(5R,5aR,8aR,9S)-5,8,8a,9-Tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-β-D-glucopyranosyl]oxy]furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;VM 26;Teniposide;NSC 122819;EPT;Vehem;Vumon;Vehem-Sandoz;S 122819;Tenoposide;23362-13-2;31514-29-1;35317-44-3;952055-45-7
CAS No.:29767-20-2
Molecular Formula:C32H32O13S
InChIKeys:InChIKey=NRUKOCRGYNPUPR-QBPJDGROSA-N
Molecular Weight:656.65
Exact Mass:656.65
EC Number:249-831-2
UNII:957E6438QA
DSSTox ID:DTXSID8023638
NCI Thesaurus Code:C857
Color/Form:Crystals from absolute ethanol
ATC Code:L - Antineoplastic and immunomodulating agents
HScode:29349990
Categories:
Characteristics-
PSA:
189 Ų
XLogP3:1.24 (LogP)
Appearance:white to beige
Density:1.6±0.1 g/cm3
Melting Point:242-246 °C
Boiling Point:864.3°C at 760 mmHg
Flash Point:476.5±34.3 °C
Refractive Index:1.697
Water Solubility:DMSO: soluble 10mg/mL, clear
Storage Conditions:-20°C Freezer
Vapor Pressure:6.8X10-26 mm Hg at 25 °C /Estimated/
Toxicity:LD50 intraperitoneal in mouse: 29570ug/kg
Specific rotation:D20 -107° (9:1 chloroform/methanol)
Henrys Law Constant:Henry's Law constant = 5.8X10-32 atm-cu m/mol at 25 °C /Estimated/
Dissociation Constants:pKa = 10.13
Collision Cross Section:266.1 Ų [M+Na]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Teniposide is a semisynthetic podophyllotoxin-derivative antineoplastic agent, which is structurally and pharmacologically related to etoposide. Teniposide differs structurally from etoposide by addition of a thenylidine ring on the glucopyranoside ring.|Hydroxyl radical reaction rate constant = 3.0X10-10 cu cm/molecule-sec at 25 °C /Estimated/
Hazard IdentificationClassification of the substance or mixture
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H350 May cause cancer
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product