YM-155 hydrochloride
355406-09-6
0.98%
2026-07-14
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName YM-155 hydrochloride Cat No CEI-1590 Description YM-155 hydrochloride is a potent and small-molecule inhibitor of survivin with IC50 value of 0.54 nM. Product Overview YM-155 hydrochloride is a novel small-molecule suppressant of surviving, the smallest member of inhibitor of apoptosis (IAP) gene family. It exhibits a potent suppressive activity against survivin but has little effect on expression levels of other IAP family members or B-cell lymphoma 2 (BCL-2) related proteins. YM155 also suppresses proliferation in a broad range of human cancer cell lines, induces tumor regression in non-small cell lung cancer (NSCLC), melanoma, bladder, aggressive non-Hodgkin lymphoma, and breast cancer xenograft models, reduces spontaneous metastases, and significantly prolongs the survival of animal harboring established metastatic tumors derived from a human triple-negative breast cancer (TNBC) cell lines. CAS No 355406-09-6 Molecular Weight 398.84 Purity 0.98 Storage Store at -20°C Synonyms YM155 hydrochloride; YM 155 hydrochloride Targets survivin IC50 0.54 nM Molecular Formula C20H19ClN4O3 Chemical Name 1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione; chloride Solubility Soluble to 55 mg/ml in DMSO and to 89 mg/ml in water Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Specialty Chemicals(c26) cas_num 355406-09-6 Basic Info-
Product Name:
1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride
Other Name:1-(2-Methoxyethyl)-2-Methyl-4,9-dioxo-3-(pyrazin-2-ylMethyl)-4,9-dihydro-1H-naphtho[2,3-d]iMidazol-3-iuM chloride;YM 155 hydrochloride;YM-155 (hydrochloride);YM155 hydrochloride;YM-155 HCl;YM155 HYDROCHLORIDE;YM 155 HYDROCHLORIDE;YM-155 (chloride);YM-155 HCl (Sepantronium HCl)
CAS No.:355406-09-6
Molecular Formula:C20H19ClN4O3
InChIKeys:NUZWGSASIPTGSA-UHFFFAOYSA-M
Molecular Weight:398.85
Exact Mass:398.1145682
DSSTox ID:DTXSID40630623
Color/Form:Light brown to brown
Categories:
Characteristics-
Critical Temperature & Pressure:
Store at -20°C
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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