Staurosporine
62996-74-1
99%
2026-06-30
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName Staurosporine Cat No CEI-0315 Description Staurosporine (AM-2282, SSP) can potently inhibit protein kinase C with IC50 of 2.7 nM. CAS No 62996-74-1 Molecular Weight 466.53 Purity >99% Storage 2 years at -20 centigrade Targets PKC Molecular Formula C28H26N4O3 Chemical Name 9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3,2,1-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, [9S-(9alpha,10beta,11beta,13alpha)]- Solubility DSMO 4 mg/mL Water In vitro Staurosporine (AM-2282, SSP) can potently inhibit protein kinase C with IC50 of 2.7 nM. Staurosporine (AM-2282) can also inhibit NADPH-Oxidase activation. Besides inhibiting protein kinase C, staurosporine (AM-2282) also inhibit cyclic AMP-dependent kinase and the tyrosine kinase pp60src. In intact human neutrophils, staurosporine can potently block the action of the phorbol ester tumor promoters with nM concentrations, but shows no inhibition to the effects of phorbol 12,13-dibutyrate on epidermal growth factor binding in mouse primary epidermal cells. aurosporine is an effective inhibitor of the EGF-stimulated receptor tyrosine kinase. In both human epidermal carcinoma A431 cells and mouse Swiss 3T3 fibroblasts, staurosporine treatment causes enhancement in high affinity EGF binding and a decrease in the phosphorylation state of the unstimulated receptor.[2] Staurosporine (AM-2282, SSP) can stop progression of normal nontransformed cells in the G1 phase of the cell cycle.The target(s) of SSP is (are) either the p33cdk/cyclin E complex itself or other protein kinase(s), activated subsequent to the cyclin D but prior to the cyclin E restriction point, the activity of which is essential for cell transit through G1. Staurosporine at a concentration of 20 nM arrests normal diploid fibroblasts 3 h into G1, and staurosporine (2 nM) induces a new G1 arrest point at 6 h into G1. category Antineoplastics(c1126) cas_num 62996-74-1 Basic Info-
Product Name:
Staurosporine
Other Name:9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-,(9S,10R,11R,13R)-;9,13-Epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one,2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-,[9S-(9α,10β,11β,13α)]-;(9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3′,2′,1′-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one;Antibiotic AM 2282;Staurosporine;Staurosporin;AM-2282;Alkaloid AM-2282 from Streptomyces;(+)-Staurosporine;Antibiotic 230;CGP 39360;109189-95-9
CAS No.:62996-74-1
Molecular Formula:C28H26N4O3
InChIKeys:InChIKey=HKSZLNNOFSGOKW-WIFUGMKFSA-N
Molecular Weight:466.53
Exact Mass:466.53
EC Number:613-127-7
NSC Number:374128
DSSTox ID:DTXSID6041131
HScode:29419090
Categories:
Characteristics-
PSA:
69.45000
XLogP3:5.07370
Appearance:off-white powder
Density:1.6±0.1 g/cm3
Melting Point:270°C
Boiling Point:677.5ºC at 760 mmHg
Flash Point:363.6±31.5 °C
Refractive Index:1.810
Water Solubility:soluble in DMSO or ethanol.soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
Storage Conditions:2-8°C
Specific rotation:D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 1B
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H340 May cause genetic defects
H350 May cause cancer
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product