Company Type:
Manufactory
Location:
United States
Qualification:
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName caspase-3 Cat No EXWM-4231 Description Caspase-3 is an effector/executioner caspase, as are caspase-6 (EC 3.4.22.59) and caspase-7 (EC 3.4.22.60). These caspases are responsible for the proteolysis of the majority of cellular polypeptides [e.g. poly(ADP-ribose) polymerase (PARP)], which leads to the apoptotic phenotype. Procaspase-3 can be activated by caspase-1 (EC 3.4.22.36), caspase-8 (EC 3.4.22.61), caspase-9 (EC 3.4.22.62) and caspase-10 (EC 3.4.22.63) as well as by the serine protease granzyme B. Caspase-3 can activate procaspase-2 (EC 3.4.22.55). Activation occurs by inter-domain cleavage followed by removal of the N-terminal prodomain. Although Asp-Glu-(Val/Ile)-Asp is thought to be the preferred cleavage sequence, the enzyme can accommodate different residues at P2 and P3 of the substrate. Like caspase-2, a hydrophobic residue at P5 of caspase-3 leads to more efficient hydrolysis, e.g. (Val/Leu)-Asp-Val-Ala-Asp┼ is a better substrate than Asp-Val-Ala-Asp┼. This is not the case for caspase-7. Belongs in peptidase family C14. Form Liquid or lyophilized powder Enzyme Commission Number EC 3.4.22.56 CAS No 169592-56-7 Storage Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC. Synonyms CPP32; apopain; yama protein Reaction Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp┼ with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3, although Val or Ala are also accepted at this position Notes This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. category Specialty Chemicals(c26) cas_num 169592-56-7 Basic Info-
Product Name:
CASPASE-3
Other Name:PROCASPASE-3;PROCASPASE-3, HIS TAG(R) HUMAN;PROCASPASE-3, HIS TAG(R), MOUSE;PROCASPASE-3 (HUMAN);PRO-CASPASE-3 (HUMAN) (REC);PRO-CASPASE-3 (HUMAN) (RECOMBINANT);PROCASPASE-3, HUMAN, RECOMBINANT, E COLI;YAMA
CAS No.:169592-56-7
Categories:
Characteristics-
Appearance:
buffered aqueous glycerol solution
Water Solubility:PBS: soluble
Storage Conditions:−70°C
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product