Cycloheximide
66-81-9
95%
2026-07-15
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Product Description
-
Seller Information
-
Description
ProductName Cycloheximide Cat No CEI-0685 Description A very active antibiotic against many yeasts and fungi. Inhibits protein synthesis in eukaryotes (but not in prokaryotes) by interfering with the translocation step. It inhibits chain initiation as well as chain elongation by acting on the 60S subunit of the eukaryote ribosome, interacting directly with enzyme translocase. Cycloheximide is used as an inhibitor to study cell-free protein biosynthesis in eukaryotes and also used to block ribosome-dependent in vivo polypeptide synthesis. It induces apoptosis in a variety of cells, but can also delay or inhibit apoptosis by other agents. Appearance Crystalline solid Product Overview A protein synthesis inhibitor CAS No 66-81-9 Molecular Weight 490 Purity >95% by NMR Storage -20 centigrade Targets SLC25A20 Molecular Formula C₁₅H₂₃NO₄ Chemical Name 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide, Actidione, Naramycin A Solubility DMSO Shipping Conditions Gel pack category Antibiotics(c1416) cas_num 66-81-9 Basic Info-
Product Name:
(-)-Cycloheximide
Other Name:2,6-Piperidinedione,4-[(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-;Naramycin A;Glutarimide,3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-;2,6-Piperidinedione,4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-,[1S-[1α(S*),3α,5β]]-;4-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]-2,6-piperidinedione;Actidion;Acti-dione;Cycloheximide;β-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]glutarimide;U 4527;TZA;Naramycin;NSC 185;Acti-Aid;Acti-dione BR;Acti-dione TGF;Acti-dione PM;Naramycin Microcapsule D 80;Cicloheximide;NM-MCD 80;Naramycin NM-MCU 80;LDN 97549;FT 3422-2;CHX;l-Cycloheximide;(-)-Cycloheximide;4630-76-6;6399-67-3;17974-04-8;21059-09-6
CAS No.:66-81-9
Molecular Formula:C15H23NO4
InChIKeys:InChIKey=YPHMISFOHDHNIV-FSZOTQKASA-N
Molecular Weight:281.34742
Exact Mass:281.35
EC Number:200-636-0
UNII:98600C0908
ICSC Number:0244
NSC Number:758187|185
UN Number:2588
DSSTox ID:DTXSID6024882
Color/Form:Plates from amyl acetate, water or 30% methanol|Crystals
HScode:29419000
Categories:
Characteristics-
PSA:
83.5
XLogP3:0.55
Appearance:White Glassy Irregular Shaped Granules
Density:1.1±0.1 g/cm3
Melting Point:119.5-121 °C
Boiling Point:492℃
Flash Point:87°0°(230°F)
Refractive Index:1.499
Water Solubility:Solubility in water, g/100ml at 2°C: 2.1
Storage Conditions:2-8°C
Toxicity:Oral-rat LD50: 2 mg/kg; Oral-Mouse LD50: 133 mg/kg
Flammability characteristics:Thermal decomposition of toxic nitrogen oxide gas
Specific rotation:-28.5 º (c=1, CHCl3)
Experimental Properties:Elemental composition: C: 64.04%; H: 8.24%; N: 4.98%; O: 22.75%|/Cycloheximide/ activity is destroyed by boiling in aqueous soln at pH 7 for 1 hr, but shows no loss of activity after 15 min boiling. At pH 2 /cycloheximide/ activity is not degraded by boiling for 1 hr.|IT HAS INTERESTING PROPERTY OF FORMING STABLE DERIV SUCH AS THE ACETATE, OXIME, & SEMICARBAZONE THAT ARE ACTIVE AS FUNGICIDES.
Air and Water Reactions:Water soluble.
Reactive Group:Amides and Imides
Reactivity Profile:CYCLOHEXIMIDE is an imide. This chemical is incompatible with strong oxidizing agents, acid chlorides and acid anhydrides. It decomposes rapidly in alkali at room temperature. (NTP, 1992)
Corrosivity:NONCORROSIVE
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Germ cell mutagenicity, Category 2
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 2
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H341 Suspected of causing genetic defects
H411 Toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P273 Avoid release to the environment.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P391 Collect spillage.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Separated from food and feedstuffs. Well closed. Keep in a well-ventilated room.
-
-
Seller Information
-
Business Type:
Manufactory
-
Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
-
Location:
Shirley, New York 11967, USA
-
Payment Terms:
TT against copy of documents,D/P
-
Average lead Time:
15
-
Total Annual Revenue:
$1 million-$2.5 million
-
Year of Establishment:
2004
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product