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5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (Dacarbazine)

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CAS No.:

4342-03-4

Price valid (until):

2026-10-18

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GIHI CHEMICALS CO.,LIMITED

Company Type:

Manufactory

Location:

China

Payment Terms:

L/C,100% TT in advance

Average Lead Time:

30 days

Qualification:

Main Products:

chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC

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Description

5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (Dacarbazine) (CAS No.: 4342-03-4) is supplied by GIHI CHEMICALS CO.,LIMITED, a Manufactory with 8 years on ECHEMI. Contact the supplier on this page to request a quotation or the latest price.

ECHEMI Editorial Reference

Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.Target: Nucleoside antimetabolite/analogApproved: May 1975Dacarbazine (DTIC) is the only single-agent approved by the Food and Drug Administration for treating metastatic melanoma. With DTIC as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5% [1]. Dacarbazine (DTIC) has activity in
Dacarbazine appears as white to ivory microcrystals or off-white crystalline solid. (NTP, 1992)
Dacarbazine appears as white to ivory microcrystals or off-white crystalline solid. (NTP, 1992)|(E)-Dacarbazine is an aromatic amide and a heteroarene.|An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.|Dacarbazine is an Alkylating Drug. The mechanism of action of dacarbazine is as an Alkylating Activity.|Dacarbazine (also known as DTIC) is an intravenously administered alkylating agent used in the therapy of Hodgkin disease and malignant melanoma. Dacarbazine therapy has been associated with serum enzyme elevations during therapy and occasional cases of severe and distinctive acute hepatic failure, probably caused by acute sinusoidal obstruction syndrome.|Dacarbazine is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)|An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)

Basic Info

Product Name:

Dacarbazine

Other Name:

1H-Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazen-1-yl)-;Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazeno)-;1H-Imidazole-4-carboxamide,5-(3,3-dimethyl-1-triazenyl)-;Imidazole-4(or 5)-carboxamide,5(or 4)-(3,3-dimethyl-1-triazeno)-;5-(3,3-Dimethyl-1-triazen-1-yl)-1H-imidazole-4-carboxamide;4-(Dimethyltriazeno)imidazole-5-carboxamide;5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide;5-(Dimethyltriazeno)imidazole-4-carboxamide;5(or 4)-(3,3-Dimethyl-1-triazeno)imidazole-4(or 5)carboxamide;5(4)-(3,3-Dimethyl-1-triazeno)imidazole-4(5)-carboxamide;4(or 5)-(3,3-Dimethyl-1-triazeno)imidazole-5(or 4)-carboxamide;5-(3,3-Dimethyltriazeno)imidazole-4-carboxamide;Dacarbazine;NSC 45388;5-(3,3-Dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide;(Dimethyltriazeno)imidazolecarboxamide;DTIC;5-(3,3-Dimethyl-1-triazenyl)imidazole-4-carboxamide;Biocarbazine R;Deticene;5-(3,3′-Dimethyl-1-triazeno)imidazole-4-carboxamide;Dacarbasine;DTIE;DTIC-Dome;NCI C04717;ICDT;ICDMT;DIC;Detimedac;37626-23-6

CAS No.:

4342-03-4

Molecular Formula:

C6H10N6O

InChIKeys:

InChIKey=FDKXTQMXEQVLRF-UHFFFAOYSA-N

Molecular Weight:

182.18

Exact Mass:

182.18

EC Number:

224-396-1

UNII:

7GR28W0FJI

NSC Number:

759610|45388

DSSTox ID:

DTXSID0020369

NCI Thesaurus Code:

C411

Color/Form:

IVORY MICROCRYSTALINE SUBSTANCE

ATC Code:

L - Antineoplastic and immunomodulating agents

HScode:

2934999090

Categories:

Other Food Additives

Characteristics

PSA:

99.73000

XLogP3:

-0.24

Appearance:

Dacarbazine appears as white to ivory microcrystals or off-white crystalline solid. (NTP, 1992)

Density:

1.5±0.1 g/cm3

Melting Point:

205 °C

Boiling Point:

456.3±55.0 °C at 760 mmHg

Flash Point:

229.7±31.5 °C

Refractive Index:

1.678

Water Solubility:

Slightly soluble in water, DMSO and ethanol/n

Storage Conditions:

2-8°C

Dissociation Constants:

pKa= 4.42

Experimental Properties:

Sensitive to oxidation; stable in neutral solutions in absence of light. Extremely light-sensitive: rapidly undergoes chemical decomposition to form 4-diazoimidazole-5-carboxamide ... .

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amides and Imides

Reactivity Profile:

DACARBAZINE decomposes explosively at its melting point (250°C). Decomposes in the presence of light. Sensitive to oxidation.

See More Dacarbazine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Skin irritation, Category 2

Eye irritation, Category 2

Acute toxicity - Category 4, Inhalation

Specific target organ toxicity â single exposure, Category 3

Germ cell mutagenicity, Category 1B

Carcinogenicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302+H312+H332 Harmful if swallowed, in contact with skin or if inhaled H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation H340 May cause genetic defects H350 May cause cancer
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P332+P317 If skin irritation occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell. P318 IF exposed or concerned, get medical advice.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Dacarbazine Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
chemicals,low price LCZ696 Intermediate,NICOTINAMIDE RIBOSIDE，NR,,4-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine,Romidepsin (FK228, Depsipeptide),Alpha-GPC

Location:
No 7 ,Huacai International Building,Dengcai Road,Sandun,Westlake District,Hangzhou,Zhejiang

Payment Terms:
L/C,100% TT in advance

Average lead Time:
30 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
101-200

Year of Establishment:
2011

Company Certificates
- ISO
- FDA
- CE
Gihi Chemicals: is specialized in the production of ester products which are used in the daily dietary supplements chemicals ,cosmetic products and skincare products since 1999.
Since 2010，GIHI CHEMICALS , begun to focus on the development and production of high-quality healthy Dietary supplements for our global high-reputation customers. The purity of all healthy Dietary supplements we provide has reached more than 99% purity. From the beginning of our products’ development, our technical engineers have chosen and design the production routes to ensure that we have been able to use biological, enzyme and water-phase green synthesis methods during the large production process to ensure that our health dietary supplements is truly high-quality ,green &environmental friendly, which are truly good and health to the human body.
Now our company has:
1 sales & management center + 3 research centers+ 4 production factories.
with ISO9001 & FDA certificate & CE certificate, accordance with GMP requirements.

1 Sales &Management center:
Add:No.567 Dengcai Street, Sandun, Westlake District, Hangzhou 310030, Zhejiang, China.
Research Center 1: (Chemical synthesis lab)
No.6, Chanyexietongchuanxing Center, Kangyang Road, Shangyu Economic and Technological Development Zone, Shaoxing, Zhejiang，China.
This research center: is specialized in chemical synthesis, our this research center could synthesis more than 300 new chemical products for many china pharmaceutical companies every year.
Research Center 2:(For Enzyme biology technical and Enzyme catalyst technical)
No.7, Lixiangxi Road, changsha Economic and Technological Development Zone, Changsha, Hunan.
Our this research center is committed to the applications of immobilized enzymes technology to the development of products such as peptides, polysaccharides, and non-natural amino acids. The products developed are widely used in medicine, health products, cosmetics, food, feed and other industries. The company adopts multidisciplinary technologies of chemistry, materials science and life sciences, which helps to meet the demand of green production while improving product quality and economic benefits. And also helps to reduces the emission of "three industrial pollution" greatly.
Research Center 3:(Biology enzyme-catalytic products)
No.2 Bio-hatch Building,No.10 Gaoxinzhongyidao, Yuehai Street,Nanshan District, Shenzhen, Guangdong, China.
This research center is specialized in biosynthesis technology as the core technology, and multi-disciplinary cross-application as target. We are the first batch company in the world to apply enzyme catalysis technology to the large-scale production of peptides, carbohydrates and nucleic acids and other special functional raw materials, and actively explore products in new application in the field. In this center, we used enzyme catalyst production methods to produce many high lever products, such as: NMN, (S)-Prox-ylane, Ectoin, Ergothioneine,etc.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	DACARBAZINE	100 G	Jul 15, 2025

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5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide (Dacarbazine)

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