Neostigmine Methyl Sulfate 99% powder
1 Inquiries
51-60-5
Pharmaceutical Grade
99%
25kg/drum
2023-01-08
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceNeostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, can not cross the blood-brain barrier.
Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.|A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
Neostigmine is a reversible inhibitor of acetylcholinesterase (AChE; Kd= 260 μM). In a rat model of knee joint inflammation, intrathecal administration of neostigmine (2-30 μg) increases endogenous acetylcholine levels and dose-dependently increases the latency of paw withdrawal in response to thermal and mechanical stimuli (ED50s = 6.6 and 3.5 μg, respectively). Neostigmine (5 μg, i.p.) restores muscle action potentials in mice with a thymopoietin-induced neuromuscular block. Formulations containing neostigmine have been used in the treatment of myasthenia gravis and Ogilvie syndrome.
Crystalline Solid
ChEBI: Neostigmine methyl sulfate is an arylammonium sulfate salt. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor.Basic Info-
Product Name:
Neostigmine Methyl Sulfate
Other Name:A sulfuric acid neostigmine;(3-(dimethylcarbamoyloxy)phenyl)trimethyl-ammoniumethylsulfate;(3-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamicester;(m-hydroxyphenyl)trimethylammoniummethylsulfatedimethylcarbamate;PROSTIGMINE;NEOSTIGIMINE BROMIDE;NEOSTIGMINE METHYL SULFATE;NEOSTIGMINE METHYL SULPHATE
CAS No.:51-60-5
Molecular Formula:C12H19N2O2.CH3O4S
InChIKeys:OSZNNLWOYWAHSS-UHFFFAOYSA-M
Molecular Weight:334.39
Exact Mass:334.119843
EC Number:200-109-5
UNII:98IMH7M386
NSC Number:93753
DSSTox ID:DTXSID40199003
Color/Form:white
HScode:29242990
Categories:
Characteristics-
PSA:
104
XLogP3:2.11750
Appearance:white powder
Melting Point:175-177 °C(lit.)
Boiling Point:457ºC
Water Solubility:1g/10mL
Storage Conditions:−20°C
Toxicity:LD50 in mice (mg/kg): 0.16 i.v.; 0.42 s.c.; 7.5 orally, (Randall, Lehmann)
Flammability characteristics:Combustible, decomposes toxic nitrogen oxides, sulfur oxides gas when burning
Critical Temperature & Pressure:-20°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Acute toxicity - Category 1, Dermal
Acute toxicity - Category 1, Inhalation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H310 Fatal in contact with skin
H330 Fatal if inhaled
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P262 Do not get in eyes, on skin, or on clothing.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P284 [In case of inadequate ventilation] wear respiratory protection.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P316 Get emergency medical help immediately.
P361+P364 Take off immediately all contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
P320 Specific treatment is urgent (see ... on this label).
Storage P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst
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Location:
https://www.dideu.com/en/
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
Above $100 million
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Total Employees:
Above 1000
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Year of Establishment:
2016
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Certifications:
ISO Certificate,REACH
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Pakistan
Neostigmine Methylsulfate
3 KG Aug 13, 2024 Post an enquiry for this product