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Vitamin E Polyethylene Glycol Succinate(Vitamin E-TPGS)

Name: Vitamin E Polyethylene Glycol Succinate(Vitamin E-TPGS)
Brand: HANDOM CHEM
SKU: pr2305121645
Price: 635 USD
Availability: InStock

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CAS No.:

9002-96-4

Grade:

Pharmaceutical Grade

Content:

26%

Port:

Dalian

Brand:

HANDOM CHEM

Packaging:

1kg per bottle or according to the specific requirements from customers.

Price valid (until):

2023-07-31

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DALIAN HANDOM CHEMICALS CO.,LTD.

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

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Product Description
Seller Information

Description

Product Detail

Product Name: Vitamin E Polyethylene Glycol Succinate(TPGS)

Alias: Tocofersolan; Vitamin E-TPGS

CAS No.: 9002-96-4

Molecular Formula: C33H54O5·(C2H4O)n

Brief Introduction:
Vitamin E polyethylene glycol succinate (TPGS) is a water-soluble derivative of vitamin E, which is formed by reacting the carboxyl group of vitamin E succinate with the hydroxyl group of polyethylene glycol. Because it contains both vitamin E lipophilic groups and polyethylene glycol hydrophilic long chains, it has good surfactant properties and water solubility, which can significantly increase the absorption of insoluble drugs in the gastrointestinal tract and improve bioavailability.

Test Items		Specifications	Test Methods
Description		White to yellowish waxy solid	Visual
Identification		Meets the requirements	ChP<0521>
Assay(D-α-tocopherol)		Not less than 26.0%	ChP<0521>
mono-TPGS		Not less than 80.0%	ChP<0512>
bis-TPGS		Not more than 10.0%	ChP<0512>
Vitamin E		Not more than 1.5%	ChP<0512>
Vitamin E Succinate		Not more than 0.2%	ChP<0512>
Solubility in water		20% Min(Clear solution within 3h)	ChP<0902>
Acidity		Not more than 1.5	ChP<0713>
Specific Rotation		Not less than +24.0°	ChP<0621>
Heavy Metals		Not more than 10ppm	ChP<0821>
Residual Solvents	Ethyl Acetate	Not more than 50ppm	ChP<0861>
Residual Solvents	Ethanol	Not more than 200ppm	ChP<0861>
Microbial Test	Total Plate Count	Not more than 1000CFU/g	ChP<1105>
	Yeasts & Moulds	Not more than 100CFU/g	ChP<1105>
	Salmonella	Negative	ChP<1106>
	Escherichia coli	Negative	ChP<1106>

Applications:
Vitamin E polyethylene glycol succinate(TPGS) has been widely used in the research of preparations, as solubilizers, absorption enhancers, emulsifiers, plasticizers, and carriers for poorly water-soluble or fat-soluble drug delivery systems, such as solid dispersions , a carrier for ocular administration, a carrier for intranasal administration, etc. In recent years, many studies have found that in addition to being used as a pharmaceutical excipient, TPGS also has many unique characteristics, such as an absorption enhancer and a multidrug resistance reversal agent, etc. TPGS can also be applied to prodrugs, micelles, liposomes, and TPGS-copolymer carriers to improve the solubility, permeability and stability of preparations, so as to achieve slow, controlled release and targeting, and promote drug absorption.

Packaging:
1kg per bottle or according to the specific requirements from customers.

Storage & Transportation:
Preserved in unopened original containers in a cool dry place before using, kept away from direct sunlight, heat and moisture; prevented from rain, strong acids or alkalis. Handle with care during transportation to prevent damage to the packages.

Shelf Life:
36 months if stored under above conditions.

Basic Info

Product Name:

α-Tocopheryl polyethylene glycol succinate

Other Name:

Poly(oxy-1,2-ethanediyl),α-[4-[[(2R)-3,4-dihydro-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-;Poly(oxy-1,2-ethanediyl),α-[4-[[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl]oxy]-1,4-dioxobutyl]-ω-hydroxy-,[2R-[2R*(4R*,8R*)]]-;Mono[2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-6-chromanyl] succinate,polyoxyethylene ether;Tocofersolan;D-α-Tocopherol polyethylene glycol 1000 succinate;TPGS;D 1T;α-Tocopherol polyethylene glycol succinate;d-α-Tocopheryl poly(ethylene glycol) 1000 succinate;Tocophersolan;α-Tocopheryl polyethylene glycol succinate;D-α-Tocopheryl polyethylene glycol succinate;d-α-Tocopheryl polyethylene glycol succinate;Vitamin E-TPGS;Eastman Vitamin ETPGS;VE-TPGS 1000;VitE-TPGS;Speziol TPGS Pharma;Kolliphor TPGS;D-α-Tocopherol acid polyethylene glycol 1000 succinate;TPGS 1000;TPGS 400-1000;TPGS 1500;Polyethylene glycol vitamin E succinate;Ethoxylated vitamin E succinate;d-α-Tocopheryl polyethylene glycol succinate;Vedrop;30999-06-5;32408-94-9;58829-13-3;75139-00-3;162849-98-1;249747-47-5;1365321-30-7;2614417-59-1

CAS No.:

9002-96-4

Molecular Formula:

(C2H4O)nC33H54O5

InChIKeys:

InChIKey=AOBORMOPSGHCAX-UHFFFAOYSA-N

Molecular Weight:

574.83

Exact Mass:

662.475769

EC Number:

618-345-6

Categories:

Polymer

Characteristics

PSA:

100.52000

XLogP3:

8.38890

Appearance:

Clear, colorless solid.

Density:

1.01g/cm3

Melting Point:

34-38ºC

Boiling Point:

662.7ºC at 760mmHg

Flash Point:

195.4ºC

Refractive Index:

1.496

Storage Conditions:

Vitamin E polyethylene glycol succinate is stable at ambient room temperature for up to 4 years. It reacts with alkalis and acids. Aqueous solutions of vitamin E polyethylene glycol succinate are stable over a pH range of 4.5–7.5 and can be further stabilized with propylene glycol.

See More α-Tocopheryl polyethylene glycol succinate Properties 

Hazard Identification

Classification of the substance or mixture

Not classified.

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	No symbol.
Signal word	No signal word
Hazard statement(s)	none
Prevention	none
Response	none
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More α-Tocopheryl polyethylene glycol succinate Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Semaglutide,Tirzepatide,HCG,Retatrutide,Cagrilintide,Medetomidine

Location:
RM702, Building 21, Liuhe Road, Ganjingzi Dist, Dalian, Liaoning, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2020

Dalian Handom Chemicals Co., Ltd.(HDC CHEM) is a professional 15-Year-Experienced Supplier of APIs & Intermediates, Pharmaceutical Excipients, Food & Nutraceutical Ingredients, Personal Care Chemicals and Specialty Chemicals from northeast of China, which strives to provide customers with high-quality products and comprehensive service across all over the world, our main products cover Retatrutide Lyophilized Powder, Retatrutide, Tirzepatide, Tirzepatide Lyophilized Powder, Semaglutide, Mazdutide, Cagrilintide, LL-37, Thymosin Alpha 1(Thymosin α1), MT-2, MOTS-c, HEP-1, TB-500, NAD+, GHK-Cu, Glow, Klow, Selank, Semax, Glutathione, 5-Amino-1MQ, ARA-290, SS-31, DSIP, SNAP-8, Medetomidine, Medetomidine Hydrochloride, Salcaprozate Sodium, Sodium 8-(2-hydroxybenzamido)octanoate, 2,6-Dimethyl Beta Cyclodextrin, mPEG-DMG-2K, mPEG-DSPE-2K, 1,2-Distearoyl-sn-3-phosphacholine(DSPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine(DOPE), Pharmaceutical Grade Fructose, Lactose Anhydrous, Lactose Monohydrate, Orotic acid anhydrous, Orotic acid monohydrate, 6-Methyluracil, Chitosan, Mushroom Chitosan, Chitosan Hydrochloride, Chitosan Oligosaccharide, Alginate Oligosaccharide, Inulin, L-Serine, Mung Bean Peptide, Walnut Peptide, Rice Peptide, Oyster Peptide, Sea Cucumber Peptide, Hydrolyzed Keratin, Folic Acid, Vitamin E Acetate, Vitamin B2, Riboflavin Sodium Phosphate, Pyridoxal 5'-phosphate Monohydrate, Vegan Vitamin D3, Vitamin A Palmitate, Vitamin A Acetate, Apple Pectin, Citrus Pectin, Sunflower Pectin, Salidroside, Urolithin A, Milk Thistle Extract, Saffron Extract, Red Clover Extract, Sulforaphane, Glucoraphanin, Soy Isoflavones, Soy Lecithin, Soya Lecithin, Egg Yolk Lecithin, Phosphatidylserine, Cooling Agent WS-3, Cooling Agent WS-5, Cooling Agent WS-10, Cooling Agent WS-12, Cooling Agent WS-23, Cooling Agent WS-27, Menthyl Lactate, Menthyl PCA, Avobenzone, Benzophenone-3 (UV-9), Benzophenone-4 (UV-284), Bis-ethylhexyloxyphenol Methoxyphenyl Triazine (Bemotrizinol), Diethylaminohydroxybenzoyl Hexyl Benzoate (UVA Plus), Diethylhexyl Butamido Triazone (Iscotrizinol), Disodium Phenyl Dibenzimidazole Tetrasulfonate (DPDT), Ethylhexyl Triazone (UVT-150), Homosalate, Octocrylene, 2-Ethylhexyl Salicylate (Octyl Salicylate), 2-Ethylhexyl Trans-4-Methoxycinnamate (OMC), 2-Phenylbenzimidazole-5-Sulfonic Acid (UV-T), Lanolin Anhydrous, Palmitoyl Tripeptide-5, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Biotinoyl Tripeptide-1, etc.
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