Beloranib 99% white powder kanbei
GMP ISO
251111-30-5
Industrial Grade
99%
qingdao
kanbei
25kg drum
2022-07-18
PVC resin,pvc paste resin,melamine
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceBeloranib has been used in trials studying the treatment of Obesity, Over-weight, Type 2 Diabetes, Craniopharyngioma, and Hypothalamic Injury, among others.|Beloranib is a fumagillin analogue and inhibitor of methionine aminopeptidase 2 (METAP2), with potential antiangiogenic and anti-obesity activity. As an irreversible inhibitor, beloranib blocks METAP2's functions, which include both protecting eukaryotic initiation factor 2 from inhibitory phosphorylation during translation, and by removing the amino-terminal methionine residue from nascent protein permitting the conversion of an inactive or non-functional protein to an active one. As a result, this agent prevents endothelial cell growth and inhibits tumor angiogenesis. In addition, METAP2 inhibition also down-regulates ERK1/2 signaling pathway, which is usually overactive in the fat tissues of obese people. Therefore, at a much lower dose, beloranib can induce liver fat utilization and reduce cholesterol and fatty acid synthesis. METAP2, a member of the dimetallohydrolase family, plays an important role during angiogenesis and is over-expressed in various cancers.CertificatesBasic Info
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Product Name:
Beloranib
Other Name:2-Propenoic acid,3-[4-[2-(dimethylamino)ethoxy]phenyl]-,(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester,(2E)-;2-Propenoic acid,3-[4-[2-(dimethylamino)ethoxy]phenyl]-,(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester,(2E)-;O-[4-(2-Dimethylaminoethoxy)-trans-cinnamoyl]fumagillol;Beloranib;ZGN 440
CAS No.:251111-30-5
Molecular Formula:C29H41NO6
InChIKeys:InChIKey=ZEZFKUBILQRZCK-MJSCXXSSSA-N
Molecular Weight:499.648
Exact Mass:499.64
UNII:FI471K8BU6
DSSTox ID:DTXSID40179800
NCI Thesaurus Code:C90656
Categories:
Characteristics-
PSA:
73.1
XLogP3:4.4
Density:1.15±0.1 g/cm3(Predicted)
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
PVC resin,pvc paste resin,melamine
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Location:
Room 405, Unit 2, Building 1, Taiji Mansion, No. 38, Nanyang Road, Jinshui District, Zhengzhou City, Henan Province
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Payment Terms:
TT against copy of documents,L/C
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Average lead Time:
90 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2022
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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