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GLP-1 peptide Exenatide CAS141758-74-9 Weight loss

Name: GLP-1 peptide Exenatide CAS141758-74-9 Weight loss
Brand: Mobelbiochem
SKU: pr2308131206
Price: 100 USD
Availability: InStock

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CAS No.:

141758-74-9

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Mobelbiochem

Packaging:

1-100g in bottles

Sample Available:

Yes

Price valid (until):

2023-09-13

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Mobel Biomaterials Technology Co.,ltd

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Peptide supplements,Cosmetic peptides,Cosmetic raw materials,Peptide

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Product Details
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Description

Product Detail

Product Name: Exenatide
Synonyms: Exendin-4, AC 2993, AC002993, AC2993A, LY2148568
Sequence:H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2
CAS#: : 141758-74-9
Molecular Formula: C184H282N50O60S
MW: 4186.60
Purity (HPLC):≥98.0%
Appearance: white powder
Storage: Shading, confined preservation
Package:1g-1kg in plastic bottle

Exenatide Acetate can be used to facilitate glucose control.

ECHEMI Editorial Reference

Exendin-4 is a 39 amino acid polypeptide and incretin mimetic involved in the glucose-dependent enhancement of insulin secretion. It was first isolated from Gila monster saliva. It also promotes the reduction of hyperglycemia, glucose-dependent suppression of inappropriately high glucagon secretion, slowing of gastric emptying, and reduction of food intake, often with body weight reduction or blunting of weight gain. The synthetic form, Exenatide, is a glucagon-like peptide-1 (GLP-1) agonist approved for the treatment of diabetes mellitus type II， has a long half-life.

Exenatide is the first drug in a new class of anti-diabetics known as the incretin mimetics, and it is indicated as adjunctive therapy to improve glycemic control in patients with type 2 diabetes who are taking metformin, a sulfonylurea, or both, but have not achieved adequate glycemic control. Exenatide is a functional analog of the human incretin Glucagon-Like Peptide-1 (GLP-1). GLP-1 is naturally released from cells in the GI tract in response to food intake and acts on its receptor on b-cells to potentiate glucose-stimulated insulin secretion. Exenatide is a long-acting agonist at the GLP-1 receptor. It is a synthetic version of a 39-amino acid peptide found in the salivary secretions of the Gila monster lizard.also moderates peak serum glucagon levels during hyperglycemic periods following meals, but does not interfere with glucagon release in response to hypoglycemia.

ChEBI: A bioactive polypeptide of 39 amino acid residues isolated from the saliva of the Gila monster (Heloderma suspectum). High-affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); potently indu es cAMP formation without stimulating amylase release in pancreatic acini; potentiates glucose-induced insulin secretion in isolated rat islets; protects against glutamate-induced neurotoxicity. A synthetic version is called exenatide.
Exendin-4 is an incretin mimetic peptide, which is composed of 39 amino acids. It is an analog of glucagon-like peptide 1 (GLP-1), and an insulinotropic agent, with a long half-life. Exendin-4 was historically isolated from the venom of Gila monster lizard calledHeloderma suspectum.
Exendin-4 Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 39 amino acids and having a molecular mass of approximately 4.2kDa. Exendin-4 is purified by proprietary chromatographic techniques.

Basic Info

Product Name:

Exendin-4

Other Name:

HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2;Exenatide (Exendin-4);Exenatide free base;XENDIN-4;EXENDIN-4;M.W. 4186.61 C184H282N50O60S;HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;HIS-GLY-GLU-GLY-THR-PHE-THR-SER-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2: HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2

CAS No.:

141758-74-9

Molecular Formula:

C184H282N50O60S

InChIKeys:

HTQBXNHDCUEHJF-AAPNSGCPNA-N

Molecular Weight:

4186.57188

EC Number:

686-356-3

Color/Form:

White to off-white

HScode:

2933290000

Categories:

Polypeptide

Characteristics

Water Solubility:

Soluble in water (1 mg/ml)

Critical Temperature & Pressure:

−20°C

Research

Class:

GLP-1 receptor agonist (exendin-based, 39-amino-acid peptide)

Status:

FDA-approved (Byetta 2005, Bydureon 2012)

Mechanism:

A synthetic 39-amino-acid peptide (exendin-4) that acts as a GLP-1 receptor agonist. It is not a GLP-1 analog but shares 53% sequence homology with human GLP-1. Exenatide enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces food intake. Bydureon is the extended-release formulation.

EC50 (GLP1R Ic50):

3.22 nM

Source:

Exendin-4 binding data: Eng J, et al. J Biol Chem. 1992;267(11):7402-7405. DrugBank: DB01276.DOI

Clinical Development:

NCT00053397

FDA:

Byetta, Bydureon BCise (approved 2005-04-28)

References

ChEMBL:

CHEMBL486

DrugBank:

DB01276

KEGG DRUG:

D04104

PubChem:

PubChem

Literature:

FDA: Byetta (NDA 021773)

Disclaimer:

Exenatide is FDA-approved as a prescription medicine (Byetta, Bydureon) for type 2 diabetes. This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.

See More Exendin-4 Properties 

Hazard Identification

Classification of the substance or mixture

Carcinogenicity, Category 2

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H351 Suspected of causing cancer H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Exendin-4 Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Peptide supplements,Cosmetic peptides,Cosmetic raw materials,Peptide

Location:
25 No.Bio-chemicals Technical Zoon,Yuhang District, Hangzhou city,Zhejiang P.R China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2020

Company Certificates
- cqc
- ISO
Mobel Biomaterials Technology Co.,ltd is a leading Trader supplier of Creatine monohydrate, Dsip, Semaglutide based in Hangzhou, Zhejiang, China. With a commitment to quality and customer satisfaction, Mobel Biomaterials Technology Co.,ltd has become a trusted name in the industry. Our product line includes a range of high-quality Creatine monohydrate, Dsip, Semaglutide, which are available at competitive prices. Mobel Biomaterials Technology Co.,ltd has established itself as a reliable supplier of chemical products on the echemi.com.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
Philippines	Exenatide (CAS: 141758-74-9)	10 G	Sep 19, 2026
Philippines	Exenatide	10 G	Sep 16, 2026
Philippines	Exenatide	10 G	Aug 13, 2026
United States	Exenatide	5	Mar 11, 2026

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GLP-1 peptide Exenatide CAS141758-74-9 Weight loss

Product Details

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