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ODM-201 Darolutamide

Name: ODM-201 Darolutamide
Brand: Senwayer
SKU: pr2308211100
Price: 300 USD
Availability: InStock

1 Inquiries

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CAS No.:

1297538-32-9

Grade:

Pharmaceutical Grade

Content:

98%

Port:

wuhan

Brand:

Senwayer

Packaging:

bag

Price valid (until):

2024-05-11

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Dingwang Technology (Wuhan) Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

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Product Description
Seller Information
Inquiry History

Description

Product Introduction

Androgen deprivation therapy (ADT) is a mainstay initial treatment for advanced hormone-sensitive prostate cancer (HSPC), but disease progression to castration-resistant prostate cancer (CRPC) invariably occurs when patients do not succumb to another disease or comorbidity. Recognition that the androgen receptor (AR) axis continues to drive disease progression has led to the development of several AR-directed approved agents, including abiraterone acetate and enzalutamide. An investigational agent, darolutamide (ODM-201, BAY-1841788), has completed early-phase clinical trials, and two global phase III trials are currently accruing patients.

Product name	ODM-201
CAS No.	1297538-32-9
MF	C19H19ClN6O2
MW	398.85
Melting point	169 - 171°C
EINECS No.	829-313-8
Boiling point	719.5±60.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
Storage	-20°C Freezer, Under inert atmosphere
Solubility	DMSO (Slightly), Methanol (Slightly)

About us

Wuhan senwayer century chemical Co.,Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Pesticide Intermediate, food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.

We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.

With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

If you are interested, pls contact me freely!

ECHEMI Editorial Reference

ODM-201 is an androgen receptor (AR) antagonist (Ki= 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50= 230 nM).In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

Basic Info

Product Name:

ODM-201

Other Name:

CS-1565;N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide;0DM021;BAY-1841788;ODM-021;0DM021;ODM 021;ODM 021;ODM-021;ODM-201;N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

CAS No.:

1297538-32-9

Molecular Formula:

C19H19ClN6O2

InChIKeys:

BLIJXOOIHRSQRB-PXYINDEMSA-N

Molecular Weight:

398.85

EC Number:

829-313-8

Color/Form:

White to Off-White

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.41±0.1 g/cm3(Predicted)

Melting Point:

169 - 171°C

Boiling Point:

719.5±60.0 °C(Predicted)

PKA:

11.10±0.10(Predicted)

Critical Temperature & Pressure:

-20°C Freezer, Under inert atmosphere

See More ODM-201 Properties 

Seller Information

Business Type:
Trader

Main Products:
API,nutrition supplements,plant extract,peptide,HCG,6-Aminocaproic acid

Location:
Room 707, Block A, Zhongxing Times Digital Trade Port, No. 79 Xudong Street, Hongshan District, Wuhan City

Payment Terms:
TT against copy of documents,L/C

Average lead Time:
10

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2020

Certifications:
Verified supplier certificate,SGS

Dingwang Technology (Wuhan) Co., Ltd located in the predominant WuHan City where is a traffic hinge of China,specilize in producing and developing pharmaceutical & its intermediates, Peptide, Nutritional supplements,food additive, Plant extracts,and in distributing the products of our own company and affiliated enterprises.
We have set up R&D center, quality inspection center and manufacturing site in Wuhan, Jiangsu and others places.
Our company has professional staff who deal with chemical R&D and scientific management, and holds several sets of analyzing instruments with high efficiency and high sensitivity, such as HPLC, GC and Spectrophotometer. Meanwhile, we possess of complete Q.A. and Q.C. system, supply chemical products with good quality and custom-tailored products according to our clients' requirement.
We have professional sales team, focus on quality and service, and we have achieved excellent performance over the years. Our company is committed to the development of international market , our products are mainly exported to many countries and regions, such as Europe, America, South-east Asia, the Middle East and Africa etc.
With our constant efforts and good service, We sincerely hope to establish long-term cooperation and common development with our customers.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	Darolutamide	100 G	Aug 21, 2023

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ODM-201 Darolutamide

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