High purity Darolutamide CAS NO.1297538-32-9
1297538-32-9
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
2024-02-05
CHEMICALS,REAGENTS
-
Product Description
-
Seller Information
-
DescriptionECHEMI Editorial ReferenceODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
ODM-201 is an androgen receptor (AR) antagonist (Ki= 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50= 230 nM).In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.Basic Info-
Product Name:
ODM-201
Other Name:CS-1565;N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide;0DM021;BAY-1841788;ODM-021;0DM021;ODM 021;ODM 021;ODM-021;ODM-201;N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide
CAS No.:1297538-32-9
Molecular Formula:C19H19ClN6O2
InChIKeys:BLIJXOOIHRSQRB-PXYINDEMSA-N
Molecular Weight:398.85
EC Number:829-313-8
Color/Form:White to Off-White
Categories:
Characteristics-
Density:
1.41±0.1 g/cm3(Predicted)
Melting Point:169 - 171°C
Boiling Point:719.5±60.0 °C(Predicted)
PKA:11.10±0.10(Predicted)
Critical Temperature & Pressure:-20°C Freezer, Under inert atmosphere
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
CHEMICALS,REAGENTS
-
Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
-
Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
-
Average lead Time:
10
-
Total Annual Revenue:
$10 million-$25 million
-
Total Employees:
11-50
-
Year of Establishment:
2011
-
-
Country Product Purchase Quantity Date Posted Post an enquiry for this product







