High Purity IGF-1 LR3 Peptide CAS 910463-68-2 IGF1 LR3

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What is IGF-1 LR3?

IGF-1 and its analogs such as Long R3 IGF-1, des(1-3)IGF-1 and R3-IGF-I, have mitogenic effects, which speed up cell replication in different tissues.

IGF-1 LR3 was developed to improve the stability and efficiency of IGF-1 for stimulating cell growth in in vitro experiments. Adding IGF-1 LR3 to cell culture speeds up cell division, which shortens the time to conduct laboratory studies.

IGF-1 LR3 achieves this by activating the IGF-1 receptors found in most human and animal cells. Activating these anabolic receptors also stimulates protein synthesis and tissue growth.

Difference between IGF-1 and IGF-1 LR3

Most of the IGF-1 naturally found in your body binds to serum proteins called IGF-1 binding proteins. This prolongs its half-life by up to 15 hours but reduces the affinity to the IGF-1 receptors.

In comparison, the IGF-1 LR3 analog appears to have a higher affinity to the anabolic IGF-1 receptors and binds less to serum proteins.

As a result, IGF-1 LR3 has enhanced potency, and animal studies report that continuous infusion with LR3 IGF-1 had up to 2-fold higher anabolic effects than IGF-1. Tested animals experienced higher weight gain and an increase in the weight of some of their organs.

The half-life of IGF-1 LR3

Currently, there is no clinical evidence reporting its half-life in the human body, but the common beliefs you may find on the Internet that it is longer than that of IGF-1 (up to 20-30 hours) appear to be unsubstantiated.

In fact, LR3 IGF-1 is most likely eliminated quite fast in the human body due to the fact that it binds less to serum proteins such as IGF-1 binding protein.

What is more, studies in mice report that IGF-1 LR3 is eliminated entirely within 4 hours of intramuscular injection, meaning its half-life in mice is less than 1 hour. The metabolites of IGF-1 LR3 had a slightly longer half-life and were detectable for up to 16 hours after the injection.

In terms of effects, animal research reveals that administering IGF-1 LR3 helps protect against muscle mass loss and catabolism during reduced periods of energy intake. The peptide was infused for 8 hours, significantly suppressing the natural IGF-1 production.

Yet, there is no clinical research reporting on its effects on humans, so there is no guarantee it will work the same way. IGF-1 LR3 is also not meant for human use and can be legally obtained only for research purposes.

Dosage

LR3 IGF-1 is available as a sterile filtered white lyophilized (freeze-dried) powder that must be reconstituted with distilled water and used for research purposes only. The vial sizes range from 0.2 to 1 mg.

For research purposes, the vial must be reconstituted with 2-10 ml of sterile water until achieving a concentration of 0.1 mg per milliliter. Afterward, the solution should be stored in a refrigerator at 4°C for 2-7 days.

Nevertheless, athletes and bodybuilders often purchase the product illegally and administer it subcutaneously. According to unofficial sources, the most common dosage when used as a performance-enhancing drug ranges from 0.2 to 1 mg per day.

These doses are much lower compared to the officially recommended doses for unmodified IGF-1, which is also available as a medication for patients with IGF-1 deficiency.

These patients take 0.04–0.12 mg/kg of IGF-1 twice daily subcutaneously, which is equal to at least 5.6 mg of IGF-1 per day for a 70 kg person.

Despite the fact that IGF-1 LR3 is an analog with 2-3 times higher potency and purportedly longer half-life, it is unlikely that taking it in doses more than ten times lower than IGF-1 may provide any noticeable effects.

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