ISO Certified Reference Material 98% Topotecan HCl 119413-54-6 Standard Reagent
KOSHER ISO FDA
123948-87-8
Food grade
99%
shenzhen
Flying
10g/1kg/ 10kg/ 25kg
2023-10-19
vitamin
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceTopotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.
Solid
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.|Topotecan is a Topoisomerase Inhibitor. The mechanism of action of topotecan is as a Topoisomerase Inhibitor.|Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy.|Topotecan is a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.CertificatesBasic Info-
Product Name:
Topotecan
Other Name:1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(S)-;(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Topotecan;Hycamptamine;SKF 104864;Topotecan lactone;SKF-S 104864;Hycamptin;NSC 609699;10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin;9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin;(S)-Topotecan;Nogitecan;Topophore C;TopoCED;(19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;Potactasol;Evotopin;133242-28-1;138121-88-7
CAS No.:123948-87-8
Molecular Formula:C23H23N3O5
InChIKeys:InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N
Molecular Weight:421.45
Exact Mass:421.45
EC Number:231-595-7
UNII:7M7YKX2N15
NSC Number:641007
DSSTox ID:DTXSID3042685
NCI Thesaurus Code:C1413
ATC Code:L01CE01|L01XX17|L - Antineoplastic and immunomodulating agents
HScode:2942000000
Categories:
Characteristics-
PSA:
103
XLogP3:0.5
Appearance:yellow liquid
Density:1.5±0.1 g/cm3
Melting Point:−114 °C(lit.)
Boiling Point:>100 °C(lit.)
Flash Point:12 °C
Refractive Index:1.734
Water Solubility:H2O: soluble
Storage Conditions:2-8°C
Vapor Pressure:613 psi ( 21.1 °C)
Vapor Density:1.3 (vs air)
Henrys Law Constant:Henry's Law constant = 1.59X10-24 atm-cu m/mol at 25 °C (est)
Dissociation Constants:pKa1 = 1.74 (imine); pKa2 = 8.00 (benzyl alcohol); pKa3 = 9.83 (amine) (est)
Experimental Properties:Light yellow to greenish powder, mp 213-218 °C (decomposes). Soluble in water up to 1 mg/mL. Hygroscopic. Heant and light sensitive /Topotecan hydrochloride/|Hydroxyl radical reaction rate constant = 2.63X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.16X10-15 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Germ cell mutagenicity, Category 2
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H341 Suspected of causing genetic defects
Precautionary statement(s) Prevention P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
vitamin
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Location:
Room 2-502, Building 6, Luneng Tehran Garden Building, No.8 Changbin Road, Xiuying district, Haikou City, Hainan Province
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment
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Average lead Time:
25 days
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Total Annual Revenue:
$2.5 million-$5 million
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Total Employees:
Less than 5
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Year of Establishment:
2023
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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