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Topotecan CAS 123948-87-8 for Scientific Research Chemical Reagents Use only

Name: Topotecan CAS 123948-87-8 for Scientific Research Chemical Reagents Use only
Brand: Leader
SKU: pr2401301033
Price: 1 USD
Availability: InStock

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CAS No.:

123948-87-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Leader

Packaging:

g/bottle

Price valid (until):

2024-03-01

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LEADER BIOCHEMICAL GROUP

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

5 days

Qualification:

Main Products:

Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

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Product Description
Seller Information

Description

About Product Technical Details

CAS:	123948-87-8
MF:	C23H23N3O5
MW:	421.45
EINECS:	687-471-1
Product Categories:	APIs;API
Mol File:	123948-87-8.mol

Topotecan Chemical Properties

Melting point	−114 °C(lit.)
Boiling point	>100 °C(lit.)
density	1.2 g/mL at 25 °C(lit.)
vapor density	1.3 (vs air)
vapor pressure	613 psi ( 21.1 °C)
Fp	12 °C
storage temp.	Sealed in dry,Store in freezer, under -20°C
solubility	H₂O: soluble
form	liquid
pka	8.92±0.40(Predicted)
color	yellow
CAS DataBase Reference	123948-87-8(CAS DataBase Reference)

D-Glucosamine hydrochloride Chemical Properties

Melting point	190-194 °C (dec.)(lit.)
alpha	72.5 º (c=2, H2O, 5hrs.)
refractive index	72 ° (C=1, H2O)
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	crystalline
color	White
Water Solubility	soluble
Merck	14,4458
BRN	4157370
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
InChI	InChI=1/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/s3
InChIKey	QKPLRMLTKYXDST-LPRXMDNASA-N
SMILES	[C@H]1(CO)OC([C@H](N)[C@@H](O)[C@@H]1O)O.Cl \|&1:0,5,7,9,r\|
LogP	-2.375 (est)
CAS DataBase Reference	66-84-2(CAS DataBase Reference)
EPA Substance Registry System	D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)

Safety Information

CAS:	4337-75-1
MF:	C15H32NNaO4S
MW:	345.47
EINECS:	224-388-8
Product Categories:
Mol File:	4337-75-1.mol

sodium 2-[methyl(1-oxododecyl)amino]ethanesulphonate Chemical Properties

Boiling point	363.5℃[at 101 325 Pa]
density	1.193[at 20℃]
vapor pressure	3.6Pa at 20℃
solubility	10mg/L in organic solvents at 20 ℃
pka	1.42[at 20 ℃]
form	Solid
color	White to Off-White
Water Solubility	180mg/L at 20℃
Stability:	Hygroscopic
LogP	-1.25 at 20℃
EPA Substance Registry System	Sodium N-lauroyl-N-methyltaurate (4337-75-1)

Product Pictures

Shop Cyclopamine CAS 4449-51-8 for Scientific Research Chemical Reagents Use only-Detailed Image 2

About Our Group

Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture high quality raw materials and refined ingredients which is widely used at different industries areas like Pharm & chemicals industry, functional active ingredients industry, nutritional Ingredients industry, health care products industry, cosmetics industry, pharmaceutical and refined food, feed, oil industry, natural plant ingredients industries, agriculture industry etcs to provide top quality of GMP standards products.

All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, agriculture raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China.

Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates.

With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people.

We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.

We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories Production Lines

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Our Factories warehouse 52000㎡

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Sales Team

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ECHEMI Editorial Reference

Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95±0.24 μM of GSCs-U87.
Solid
Topotecan is a pyranoindolizinoquinoline used as an antineoplastic agent. It is a derivative of camptothecin and works by binding to the topoisomerase I-DNA complex and preventing religation of these 328 single strand breaks. It has a role as an EC 5.99.1.2 (DNA topoisomerase) inhibitor and an antineoplastic agent.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA topoisomerases, type I.|Topotecan is a Topoisomerase Inhibitor. The mechanism of action of topotecan is as a Topoisomerase Inhibitor.|Irinotecan and topotecan are semisynthetic derivatives of the plant alkaloid camptothecin and are used as antineoplastic agents in the therapy of colorectal, ovarian and non-small cell lung cancer. Both irinotecan and topotecan are associated with an appreciable rate of serum enzyme elevations during therapy, and irinotecan has been implicated in causing steatohepatitis when given as cyclic anticancer therapy.|Topotecan is a semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Topotecan inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery.|An antineoplastic agent used to treat ovarian cancer. It works by inhibiting DNA TOPOISOMERASES, TYPE I.

Certificates

Basic Info

Product Name:

Topotecan

Other Name:

1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(4S)-;1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione,10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-,(S)-;(4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;Topotecan;Hycamptamine;SKF 104864;Topotecan lactone;SKF-S 104864;Hycamptin;NSC 609699;10-Hydroxy-9-[(dimethylamino)methyl]-(20S)-camptothecin;9-(N,N-Dimethylaminomethyl)-10-hydroxycamptothecin;(S)-Topotecan;Nogitecan;Topophore C;TopoCED;(19S)-8-[(Dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0[2,11].0[4,9].0[15,20]]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione;Potactasol;Evotopin;133242-28-1;138121-88-7

CAS No.:

123948-87-8

Molecular Formula:

C23H23N3O5

InChIKeys:

InChIKey=UCFGDBYHRUNTLO-QHCPKHFHSA-N

Molecular Weight:

421.45

Exact Mass:

421.45

EC Number:

231-595-7

UNII:

7M7YKX2N15

NSC Number:

641007

DSSTox ID:

DTXSID3042685

NCI Thesaurus Code:

C1413

ATC Code:

L01CE01|L01XX17|L - Antineoplastic and immunomodulating agents

HScode:

2942000000

Categories:

Antineoplastic Agents

Characteristics

PSA:

103

XLogP3:

0.5

Appearance:

yellow liquid

Density:

1.5±0.1 g/cm3

Melting Point:

−114 °C(lit.)

Boiling Point:

>100 °C(lit.)

Flash Point:

12 °C

Refractive Index:

1.734

Water Solubility:

H2O: soluble

Storage Conditions:

2-8°C

Vapor Pressure:

613 psi ( 21.1 °C)

Vapor Density:

1.3 (vs air)

Henrys Law Constant:

Henry's Law constant = 1.59X10-24 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 1.74 (imine); pKa2 = 8.00 (benzyl alcohol); pKa3 = 9.83 (amine) (est)

Experimental Properties:

Light yellow to greenish powder, mp 213-218 °C (decomposes). Soluble in water up to 1 mg/mL. Hygroscopic. Heant and light sensitive /Topotecan hydrochloride/|Hydroxyl radical reaction rate constant = 2.63X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 1.16X10-15 cu cm/molec-sec at 25 °C (est)

See More Topotecan Properties 

Hazard Identification

Classification of the substance or mixture

Germ cell mutagenicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H341 Suspected of causing genetic defects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Topotecan Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
Above 1000

Year of Establishment:
2014

Company Certificates
- Level A of Tax Credit Registration Assessment by Government
- Good Product Quality Management Certificate of Shanxi Province,China
- Company Trade Union Qualification Certificate
- Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
- AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
- FDA
24 Hours Team Service
Email
info@leader-biogroup.com
Hot Line
+86-029-68895030
+86-029-68569961
+86-029-68569962
Fax
+86-029-68895030

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories Base with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world.
- Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.
  
  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.
  
  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.
  
  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
- Process Capability : It has more than 100 sets of multi-functional reaction reactors, such as 100l~6300l enamel, stainless steel, Hastelloy, etc. It can realize Grignard, coupling, bromination, Wittig reaction and other conventional reactions. There are microchannel reactor workshops, which can realize continuous production, energy conservation and emission reduction. It can realize high pressure, high vacuum rectification, ultra-low temperature (-80 ℃ ~-100 ℃), ultra-high temperature (300 ℃ ~400 ℃) and other special reactions. It can realize the customization and processing of customers' products.
Factory Overview

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GROUP HONOR
Honor Name: Level A of Tax Credit Registration Assessment
Issued By:National Administration of Taxation & Shaanxi Tax Bureau
Authorised Date:2018-09-16
Description: National Administration of Taxation & Shaanxi Tax Bureau

Honor Name: AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
Issued By:China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description:AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China

Honor Name:Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
Issued By: China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description: Excellent Group Enterprise of Quality and Integrity in Shaanxi Province,China

Honor Name: Products Patent Certificates
Country Product Purchase Quantity Date Posted

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Topotecan CAS 123948-87-8 for Scientific Research Chemical Reagents Use only

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Factory Logistics Departments

GROUP HONOR

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Email	info@leader-biogroup.com
Hot Line	+86-029-68895030
	+86-029-68569961
	+86-029-68569962
Fax	+86-029-68895030