2'-Fucosyllactose (2'-FL)

HMOs play a crucial role in neonatal protection and development. Most notably, they develop the neonatal gut and immune system through various modes of action, including pathogen protection, gut microbiome maturation, cultivation of gut barrier function, and immune cell maturation, while supporting a functional nervous system in the central nervous system , and are effective in altering the systemic immune system and immune cells in the GI tract. HMOs are more effective than prebiotics . Alternatively, HMOs also play an important role in the ability to regulate adult immune function and the intestinal barrier.

Items	Specifications
Structure
Molecular Formula	C18H32O15
Molecular Weight (MW)	488.44
CAS Number	41263-94-9
Colour	White to Off-White
Appearance	Powder
Application(s)	Infant formula，Functional food/beverage, dietary supplement
Function	2-fucosyllactose (2 '-FL), which regulates CD14 expression, alleviates colitis and regulates intestinal microbes, stimulates T cells to increase the production of IFN-γ and reduce the production of IL-6, IL-17 and TNF-α cytokines【1】【2】.

References:

【1】Eiwegger, T., Stahl, B., Schmitt, J., Boehm, Günther, Gerstmayr, M., & Pichler, J., et al. (2004). Human milk--derived oligosaccharides and plant-derived oligosaccharides stimulate cytokine production of cord blood t-cells in vitro. Pediatric Research, 56(4), 536. 

【2】 Hester, S. N., Chen, X., Li, M., Monaco, M. H., Comstock, S. S., & Kuhlenschmidt, T. B., et al. (2013). Human milk oligosaccharides inhibit rotavirus infectivity in vitro and in acutely infected piglets. Br J Nutr, 110(07), 1233-1242.