Chinese Gallnut Extract Gallic acid (Anhydrous gallic acid) 99% CAS NO.149-91-7

What is Gallic acid ?

Gallic Acid,  is a natural ingredient extracted from traditional Chinese herbs such as Chinese gallnut, Pomegranate, Tea Leaf, and Rhubarb, and has the effects of generating fluids and quenching thirst, stopping bleeding and cooling blood. It is commonly used clinically for the treatment of dry mouth, sore throat, haemoptysis, mouth and tongue sores caused by lung-heat and fluid injury, as well as bruises and injuries. According to Western medicine, Gallic acid is a natural polyphenolic compound, and according to modern pharmacological research, Pentosanic acid has certain anti-inflammatory, antioxidant, antiviral, antibacterial and other biological activities.

1.Gallic acid is used in industry:

(1) Used in the production of permanent blue ink.

(2) It is used as an operating aid in cast and lithographic printing.

(3) Photographic developing agent.

(4) Used as cleaning aids in the semiconductor industry.

(5) Used in tanning supplies and hair dyeing preparations.

(6) Used in the preparation of antirust primer and aluminium alloy organic coating, and in the preparation of water-based drilling mud with fluidizing agent.

(7) Ultraviolet ray absorber, flame retardant.

(8) Used as analytical reagent for alkaloids, metals and inorganic acids.

2.Pharmaceutical use : astringent, haemostatic, antidiarrhoeal; used in antibacterial, antiviral and antitumour drugs.

1. Anti-tumour effects

Inhibition of tumour formation: Tumour formation is a multifactorial, multistep and multigene mutation process. Many chemical carcinogens are known to induce and promote tumour formation, while gallic acid has preventive and inhibitory effects on all stages of tumour formation. Gallic acid can inhibit the pro-carcinogenic effects of guanylate decarboxylase (ODC).

2.Cytotoxicity: Gallic acid can inhibit and directly kill tumour cells. When screening antitumour drugs using traditional Chinese medicine, it was found that GA showed cytotoxic effects on primary cultured rat hepatocytes and macrophages at ICs of 4.8-13.2 ml. It showed less cytotoxic effect on fibroblasts and endothelial cells.

3) Inhibition of tumour angiogenesis: Neovascularisation is a crucial pathological process in tumour growth and metastasis, and the activation, proliferation, migration and tubule formation of vascular endothelial cells (VEC ) are its key steps. The finding that gallic acid inhibits tumour vascular growth due to synergistic or potent promotional effects with other unidentified extracts suggests a natural and easily controlled dosing regimen, and provides clinical rationale for the anti-VEC regeneration properties of gallic acid .

3.Trypanocidal effect

African trypanosomes are flagellated protozoan parasites that can cause sleep disorders in humans and animals.GA is a potent trypanocidal agent against both bloodstream and pre-circulating trypanosomes, and the effect is dependent on the number of trypanosomes: the LD50 value of GA is (46.96_+1.28)I*m for bloodstream and (30.02_+3.49) m for pre-circulating trypanosomes.The study on the mechanism of action of trypanocides induced by GA shows that the pre-treatment with SOD and/or catalase can significantly decrease the GA-induced trypanocidal effect. that pre-treatment with SOD and/or catalase significantly reduced the GA-induced trypanocidal effect.

3. Gallic acid has a strong inhibitory effect on Escherichia coli, Staphylococcus aureus, Pasteurella, Streptococcus, and the bacteriostatic effect is significantly better than that of safranin, and slightly worse than that of norfloxacin nicotinate. The anti-NDV viral activity of gallic acid, a functional component of Pu-erh tea, was determined by cytopathic method. The results showed that gallic acid possessed anti-NDV viral activity. The effect of gallic acid on the action of PPAK receptors was explored using cellular models.