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China Largest Manufacturer Supply High Purity Clioquinol CAS 130-26-7

Name: China Largest Manufacturer Supply High Purity Clioquinol CAS 130-26-7
Brand: Leader
SKU: pr2312141022
Price: 1 USD
Availability: InStock

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CAS No.:

130-26-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Brand:

Leader

Packaging:

25KG/Drum

Price valid (until):

2024-01-14

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LEADER BIOCHEMICAL GROUP

Company Type:

Manufactory

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

5 days

Qualification:

Main Products:

Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

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Product Description
Seller Information
Inquiry History

Description

About Product Technical Details

Clioquinol Chemical Properties

Melting point	175-183 °C
Boiling point	350.4±37.0 °C(Predicted)
density	1.8959 (estimate)
vapor pressure	0Pa at 25℃
storage temp.	2-8°C
solubility	Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).
pka	pKa 8.12(50%aqEtOH t=35.0±0.1 I=0.00 N2atmosphere)(Approximate)
form	Solid
color	Light Beige to Beige
Water Solubility	<0.1 g/100 mL at 20 ºC
Merck	14,5031
BRN	153637
LogP	1.523 at 24℃
CAS DataBase Reference	130-26-7(CAS DataBase Reference)
NIST Chemistry Reference	5-Chloro-7-iodo-8-quinolinol(130-26-7)
EPA Substance Registry System	Clioquinol (130-26-7)

D-Glucosamine hydrochloride Chemical Properties

Melting point	190-194 °C (dec.)(lit.)
alpha	72.5 º (c=2, H2O, 5hrs.)
refractive index	72 ° (C=1, H2O)
storage temp.	2-8°C
solubility	H₂O: 0.1 g/mL, clear, colorless
form	crystalline
color	White
Water Solubility	soluble
Merck	14,4458
BRN	4157370
Stability:	Stable. Incompatible with strong oxidizing agents. Combustible.
InChI	InChI=1/C6H13NO5.ClH/c7-3-5(10)4(9)2(1-8)12-6(3)11;/h2-6,8-11H,1,7H2;1H/t2-,3-,4-,5-,6?;/s3
InChIKey	QKPLRMLTKYXDST-LPRXMDNASA-N
SMILES	[C@H]1(CO)OC([C@H](N)[C@@H](O)[C@@H]1O)O.Cl \|&1:0,5,7,9,r\|
LogP	-2.375 (est)
CAS DataBase Reference	66-84-2(CAS DataBase Reference)
EPA Substance Registry System	D-Glucose, 2-amino-2-deoxy-, hydrochloride (66-84-2)

Safety Information

Product Pictures

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About Our Group

Since 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories with shares and subordinates.We focus on manufacture high quality raw materials and refined ingredients which is widely used at different industries areas like Pharm & chemicals industry, functional active ingredients industry, nutritional Ingredients industry, health care products industry, cosmetics industry, pharmaceutical and refined food, feed, oil industry, natural plant ingredients industries, agriculture industry etcs to provide top quality of GMP standards products.

All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, agriculture raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world. Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China.

Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research. Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates.

With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products. Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people.

We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.

We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.

Our Factories Production Lines

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Our Factories warehouse 52000㎡

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Sales Team

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ECHEMI Editorial Reference

Almost white, light yellow, brownish-yellow or yellowish-grey powder.ChEBI: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has al o been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.Cream-colored to brownish-yellow powder. Practically odo
Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.
Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.|5-chloro-7-iodoquinolin-8-ol is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. It has a role as an antifungal agent, an antineoplastic agent, an antimicrobial agent, an antibacterial agent, a chelator, an antiprotozoal drug and a copper chelator. It is an organochlorine compound, an organoiodine compound and a monohydroxyquinoline.|Clioquinol was withdrawn in 1983 due to neurotoxicity.|Clioquinol is a Standardized Chemical Allergen. The physiologic effect of clioquinol is by means of Increased Histamine Release, and Cell-mediated Immunity.|Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.|A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.

Certificates

Basic Info

Product Name:

Clioquinol

Other Name:

8-Quinolinol,5-chloro-7-iodo-;5-Chloro-7-iodo-8-quinolinol;Alchloquin;Amebil;Amoenol;Bactol;5-Chloro-8-hydroxy-7-iodoquinoline;5-Chloro-7-iodo-8-hydroxyquinoline;Chloroiodoquine;Clioquinol;Eczecidin;Emaform;Enteroquinol;Entero-Vioform;Enterozol;Entrokin;Iodenterol;Iodochlorhydroxyquin;Iodochlorhydroxyquinol;7-Iodo-5-chloroxine;Iodoenterol;Nioform;Quinambicide;Rometin;Vioform;Iodochloroxyquinoline;Chinoform;Cifoform;5-Chloro-7-iodo-8-oxyquinoline;7-Iodo-5-chloro-8-hydroxyquinoline;Quinoform;Dioquinol;8-Hydroxy-7-iodo-5-chloroquinoline;Chloroiodoquin;Barquinol;Budoform;Cliquinol;Hi-Enterol;Iodochloroxine;Iodochloroquine;Chlorojodochin;Iodoxyquinoline;Lekosept;Enteroseptol;Quinoform (antiseptic);Quiniodochlor;Dizenterol;Rheaform;Vioformio;Quin-O-Creme;Hi-Eneterol;Rheaform Boluses;Cort-Quin;NSC 3531;NSC 74938;Quinidochlor;22112-03-4;736176-41-3

CAS No.:

130-26-7

Molecular Formula:

C9H5ClINO

InChIKeys:

InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N

Molecular Weight:

305.5

Exact Mass:

305.50

BRN:

153637

EC Number:

204-984-4

UNII:

7BHQ856EJ5

NSC Number:

759822|3531

DSSTox ID:

DTXSID7022837

NCI Thesaurus Code:

C65337

Color/Form:

Brownish-yellow, bulky powder|Yellow brown needles from alcohol, acetic acid.|A voluminous, spongy, yellowish to white brownish powder

ATC Code:

D - Dermatologicals|G - Genito urinary system and sex hormones|P - Antiparasitic products, insecticides and repellents|S - Sensory organs

HScode:

2933492250

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

33.1

XLogP3:

3.86

Appearance:

Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.

Density:

1.8959 (estimate)

Melting Point:

178-179 °C

Boiling Point:

350.4±37.0 °C(Predicted)

Flash Point:

165.7±26.5 °C

Refractive Index:

1.768

Water Solubility:

H2O: <0.1 g/100 mL at 20 ºC;soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).

Storage Conditions:

2-8°C

Toxicity:

Oral-rat LD50: > 5000 mg/kg; Oral-Mouse LD50: 69 mg/kg

Flammability characteristics:

Combustible; Fire breaks down toxic nitrogen oxides, iodide and chloride fumes

Odor:

Practically odorless

Collision Cross Section:

138.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Decompose at about 178-179 °C

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

IODOCHLOROHYDROXYQUINOLINE is incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides (NTP, 1992). Darkens on exposure to light.

See More Clioquinol Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Clioquinol cream should be stored in collapsible tubes or in tight, light-resistant containers. Topical preparations containing clioquinol should be stored at a temperature less than 30 deg C; freezing should be avoided.

See More Clioquinol Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Biochemicals Ingredients,Vitamin Amino Acid Ingredients,Cosmestic Ingredients,Pharma Chemicals,Organic Fine Chemicals,Food Nutrient Ingredients

Location:
National Aerospace Economic & Technical Development Zone,Chang'an,Xi'an,China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
5 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
Above 1000

Year of Establishment:
2014

Company Certificates
- Level A of Tax Credit Registration Assessment by Government
- Good Product Quality Management Certificate of Shanxi Province,China
- Company Trade Union Qualification Certificate
- Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
- AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
- FDA
24 Hours Team Service
Email
info@leader-biogroup.com
Hot Line
+86-029-68895030
+86-029-68569961
+86-029-68569962
Fax
+86-029-68895030

Leader Biochemical Group is a large leader incorporated industry manufacturers and suppliers of advanced refined raw materials From the year of 1996 when our factory was put into production to year of 2020, our group has successively invested in more than 52 factories Base with shares and subordinates.We focus on manufacture Pharm & chemicals, functional active ingredients, nutritional Ingredients, health care products, cosmetics, pharmaceutical and refined feed, oil, natural plant ingredients industries to provide top quality of GMP standards products.All the invested factories' product lines cover API and intermediates, vitamins, amino acids, plant extracts, daily chemical products, cosmetics raw materials, nutrition and health care products, food additives, feed additives, essential oil products, fine chemical products and agricultural chemical raw materials And flavors and fragrances. Especially in the field of vitamins, amino acids, pharmaceutical raw materials and cosmetic raw materials, we have more than 20 years of production and sales experience. All products meet the requirements of high international export standards and have been recognized by customers all over the world.
- Our manufacture basement & R&D center located in National Aerospace Economic & Technical Development Zone Xi`an Shaanxi China. Now not only relying on self-cultivation and development as well as maintains good cooperative relations with many famous research institutes and universities in China. Now, we have closely cooperation with Shanghai Institute of Organic Chemistry of Chinese Academy of Science, Beijing Institute of Material Medical of Chinese Academy of Medical Science, China Pharmaceutical University, Zhejiang University. Closely cooperation with them not only integrating Science and technology resources, but also increasing the R&D speed and improving our R&D power. Offering Powerful Tech supporting Platform for group development. Keep serve the manufacture and the market as the R&D central task, focus on the technical research.
  
  Now there are 3 technology R & D platforms including biological extract, microorganism fermentation and chemical synthesis, and can independently research and develop kinds of difficult APIs and pharmaceutical intermediates. With the strong support of China State Institute of Pharmaceutical Industry (hereinafter short for CSIPI), earlier known as Shanghai Institute of Pharmaceutical Industry (SIPI), we have unique advantages in the R & D and industrialization of high-grade, precision and advanced products.
  
  Now our Group technical force is abundant, existing staff more that 1000 people, senior professional and technical staff accounted for more than 50% of the total number of employees, including 15 PhD research and development personnel, 5 master′ S degree in technical and management personnel 9 people. We have advanced equipment like fermentation equipment and technology also extraction, isolation, purification, synthesis with rich production experience and strict quality control system, According to the GMP required, quickly transforming the R&D results to industrial production in time, it is our advantages and our products are exported to North and South America, Europe, Middle East, Africa, and other five continents and scale the forefront in the nation, won good international reputation.
  
  We believe only good quality can bring good cooperation, quality is our key spirit during our production, we are warmly welcome clients and partner from all over the world contact us for everlasting cooperation, Leader will be your strong, sincere and reliable partner in China.
- Process Capability : It has more than 100 sets of multi-functional reaction reactors, such as 100l~6300l enamel, stainless steel, Hastelloy, etc. It can realize Grignard, coupling, bromination, Wittig reaction and other conventional reactions. There are microchannel reactor workshops, which can realize continuous production, energy conservation and emission reduction. It can realize high pressure, high vacuum rectification, ultra-low temperature (-80 ℃ ~-100 ℃), ultra-high temperature (300 ℃ ~400 ℃) and other special reactions. It can realize the customization and processing of customers' products.
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GROUP HONOR
Honor Name: Level A of Tax Credit Registration Assessment
Issued By:National Administration of Taxation & Shaanxi Tax Bureau
Authorised Date:2018-09-16
Description: National Administration of Taxation & Shaanxi Tax Bureau

Honor Name: AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China
Issued By:China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description:AAA TOP Credit Excellent Group Enterprise of Shanxi Province,China

Honor Name:Excellent Group Enterprise of Quality and credit in Shaanxi ProvinceChina
Issued By: China Association of Shaanxi product Quality management Center
Authorised Date:2018-12-31
Description: Excellent Group Enterprise of Quality and Integrity in Shaanxi Province,China

Honor Name: Products Patent Certificates

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Africa	Clioquinol	1 KG	Apr 16, 2026

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China Largest Manufacturer Supply High Purity Clioquinol CAS 130-26-7

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

Factory Logistics Departments

GROUP HONOR

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Email	info@leader-biogroup.com
Hot Line	+86-029-68895030
	+86-029-68569961
	+86-029-68569962
Fax	+86-029-68895030