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API Clioquinol

Name: API Clioquinol
Brand: Hyper Chem
SKU: pr2604161314
Price: 800 USD
Availability: InStock

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CAS No.:

130-26-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Sample Available:

Yes

Price valid (until):

2026-05-16

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Details
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Description

Name	Clioquinol
CAS number	130-26-7
Description	Clioquinol metal ion chelator that crosses the blood brain barrier and acts as a neurotoxic antibiotic. Clioquinol reduced adhesions at significant level via decreasing the inflammation and fibroblastic activity in the adhesion-induced rats. At macroscopic level, carboxymethylcellulose and clioquinol were the most potent agents in reducing adhesions. Clioquinol recently has shown promising results in the treatment of Alzheimer's disease and in cancer therapy, both of which also are thought to be due to clioquinol's ability as a lipophilic copper chelator.
Related CAS #	130-26-7 (free base) 16524-58-6 (sulfate)
Synonym	Clioquinol, Iodochlorhydroxyquin, Chinoform, Vioform, EnteroVioform, Entero Septol; Iodochlorohydroxyquin; NSC 3531; NSC3531; NSC-3531; NSC 74938; NSC74938; NSC-74938
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Clioquinol More Info

1. Product Overview

Clioquinol (Iodo-Chloro-Hydroxyquinoline) is a halogenated 8-hydroxyquinoline derivative that functions as a local antifungal agent with broad antimicrobial activity. Originally developed as an antibacterial and disinfectant compound, it has demonstrated additional potential in research applications for neuroprotection and anticancer studies.

Key Product Details

CAS Number: 130-26-7

Molecular Formula: C₉H₅ClINO

Molecular Weight: 305.5 g/mol

IUPAC Name: 5-chloro-7-iodo-8-quinolinol

UNII: 7BHQ856EJ5

PubChem ID: 2788

Appearance: Light brown powder

Melting Point: 171-174°C

2. Pharmacology & Mechanism of Action

Antimicrobial Activity

Clioquinol exhibits broad-spectrum antimicrobial activity:

Antifungal: Active against fungi including Candida, Microsporum, Trichophyton, and A. fumigatus

Antibacterial: Effective against gram-positive bacteria such as Staphylococci

Mechanism: Exhibits bacteriostatic rather than bactericidal action

Metal Chelation: Functions as a metal-chelating antimicrobial, binding to essential metals like copper and zinc

Neuroprotective Properties

Research has shown Clioquinol can:

Reduce brain atrophy and iron content in mouse models

Increase tyrosine hydroxylase phosphorylation in substantia nigra pars compacta

Restore behavioral deficits in tau knockout mouse models (wheel test, Y-maze test)

Act as a mitophagy inducer

3. Therapeutic Applications

Approved Indications

Topical Antifungal: 3% cream formulation for skin infections

Antimicrobial Cream: Combination with hydrocortisone (3% clioquinol + 1% hydrocortisone) for inflammatory dermatologic disorders

Vaginal Preparation: Anti-infective treatment

Ophthalmic Use: Anti-infective eye drops

Otic Use: Otic drops for ear infections

Research Applications

Alzheimer's Disease: Potential therapeutic for reducing amyloid-beta and metal dyshomeostasis

Anticancer: Induces cell death in cancer cell lines such as DU 145 and DU145 cells

Antiparasitic: Used for experimental antiprotozoal studies

Autophagy Modulator: Functions in cellular metabolism research

4. Product Specifications

Available Formulations

Clioquinol is available in several pharmaceutical forms:

Topical Cream at 3% concentration

Vaginal Cream in combination preparations

Dental Paste for oral use

Research Grade Specifications

Purity: 96-98%

Form: Powder or 10mM solution in DMSO

Storage: Powder at -20°C; DMSO solution at -20°C

Shelf Life: 1-2 years

Packaging: Available in 100 mg, 500 mg, 1 g, 5 g, and 1 mL (10mM DMSO)

5. Safety & Handling

Hazard Classification

Acute Oral Toxicity: Can cause poisoning if swallowed

UN Number: Classified as Class 6.1 dangerous goods

Risk: Treat as hazardous until more information available

Handling Precautions

Avoid contact with skin and eyes

Use in well-ventilated areas

Prevent inhalation of dust and aerosols

Store in cool, dry, well-ventilated place

Keep container tightly sealed

Emergency Measures

Eye Contact: Rinse immediately with plenty of water

Skin Contact: Wash with soap and water

Inhalation: Move to fresh air

Ingestion: Seek immediate medical attention

6. Regulatory Information

Clioquinol has varying regulatory status across regions:

FDA: Approved but withdrawn in 1973

EMA: Available in combination products

Canada: VIOFORM HYDROCORTISONE approved

Vietnam: Included in National Drug Formulary with ATC codes D08AH30, D09AA10, G01AC02, P01AA02, and S02AA05

7. Key Features & Benefits

Clioquinol offers multiple advantages for pharmaceutical and research applications:

Broad-Spectrum Activity: Effective against fungi, gram-positive bacteria, and protozoa

Metal Chelation: Unique mechanism targeting essential metal ions

Research Versatility: Applications in neurology, oncology, and cell biology

Well-Characterized: Extensive safety and pharmacology data available

Multiple Formulations: Available in cream, ointment, and solution forms

8. References & Further Information

For complete prescribing information, safety data sheets (SDS), and certificates of analysis (CoA), please contact authorized distributors or visit official pharmaceutical supplier websites.

Note: Research grade Clioquinol is intended for laboratory research only and should not be used for clinical or medical purposes.

ECHEMI Editorial Reference

Almost white, light yellow, brownish-yellow or yellowish-grey powder.ChEBI: A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has al o been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.Cream-colored to brownish-yellow powder. Practically odo
Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.
Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.|5-chloro-7-iodoquinolin-8-ol is a monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease. It has a role as an antifungal agent, an antineoplastic agent, an antimicrobial agent, an antibacterial agent, a chelator, an antiprotozoal drug and a copper chelator. It is an organochlorine compound, an organoiodine compound and a monohydroxyquinoline.|Clioquinol was withdrawn in 1983 due to neurotoxicity.|Clioquinol is a Standardized Chemical Allergen. The physiologic effect of clioquinol is by means of Increased Histamine Release, and Cell-mediated Immunity.|Clioquinol is an orally bioavailable, lipophilic, copper-binding, halogenated 8-hydroxyquinoline with antifungal, antiparasitic and potential antitumor activities. Clioquinol forms a stable chelate with copper (copper (II) ions), which inhibits the chymotrypsin-like activity of the proteasome; consequently, ubiquitinated proteins may accumulate in tumor cells, followed by tumor cell apoptosis and the inhibition of tumor angiogenesis. In addition, the clioquinol-copper complex appears to decrease the expression of androgen receptors (AR) in human copper-enriched prostate cancer cells. Serum levels of copper are often elevated in patients with cancer; copper chelation may inhibit copper-dependent endothelial cell proliferation and tumor secretion of angiogenic factors.|A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.

Basic Info

Product Name:

Clioquinol

Other Name:

8-Quinolinol,5-chloro-7-iodo-;5-Chloro-7-iodo-8-quinolinol;Alchloquin;Amebil;Amoenol;Bactol;5-Chloro-8-hydroxy-7-iodoquinoline;5-Chloro-7-iodo-8-hydroxyquinoline;Chloroiodoquine;Clioquinol;Eczecidin;Emaform;Enteroquinol;Entero-Vioform;Enterozol;Entrokin;Iodenterol;Iodochlorhydroxyquin;Iodochlorhydroxyquinol;7-Iodo-5-chloroxine;Iodoenterol;Nioform;Quinambicide;Rometin;Vioform;Iodochloroxyquinoline;Chinoform;Cifoform;5-Chloro-7-iodo-8-oxyquinoline;7-Iodo-5-chloro-8-hydroxyquinoline;Quinoform;Dioquinol;8-Hydroxy-7-iodo-5-chloroquinoline;Chloroiodoquin;Barquinol;Budoform;Cliquinol;Hi-Enterol;Iodochloroxine;Iodochloroquine;Chlorojodochin;Iodoxyquinoline;Lekosept;Enteroseptol;Quinoform (antiseptic);Quiniodochlor;Dizenterol;Rheaform;Vioformio;Quin-O-Creme;Hi-Eneterol;Rheaform Boluses;Cort-Quin;NSC 3531;NSC 74938;Quinidochlor;22112-03-4;736176-41-3

CAS No.:

130-26-7

Molecular Formula:

C9H5ClINO

InChIKeys:

InChIKey=QCDFBFJGMNKBDO-UHFFFAOYSA-N

Molecular Weight:

305.5

Exact Mass:

305.50

BRN:

153637

EC Number:

204-984-4

UNII:

7BHQ856EJ5

NSC Number:

759822|3531

DSSTox ID:

DTXSID7022837

NCI Thesaurus Code:

C65337

Color/Form:

Brownish-yellow, bulky powder|Yellow brown needles from alcohol, acetic acid.|A voluminous, spongy, yellowish to white brownish powder

ATC Code:

D - Dermatologicals|G - Genito urinary system and sex hormones|P - Antiparasitic products, insecticides and repellents|S - Sensory organs

HScode:

2933492250

Categories:

Antiparasitic Drugs

Characteristics

PSA:

33.1

XLogP3:

3.86

Appearance:

Iodochlorohydroxyquinoline is a cream-colored to brownish-yellow powder. Practically odorless. Decomposes at 178-179°C. Used as a topical anti-infective.

Density:

1.8959 (estimate)

Melting Point:

178-179 °C

Boiling Point:

350.4±37.0 °C(Predicted)

Flash Point:

165.7±26.5 °C

Refractive Index:

1.768

Water Solubility:

H2O: <0.1 g/100 mL at 20 ºC;soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).

Storage Conditions:

2-8°C

Toxicity:

Oral-rat LD50: > 5000 mg/kg; Oral-Mouse LD50: 69 mg/kg

Flammability characteristics:

Combustible; Fire breaks down toxic nitrogen oxides, iodide and chloride fumes

Odor:

Practically odorless

Collision Cross Section:

138.2 Å² [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

Experimental Properties:

Decompose at about 178-179 °C

Air and Water Reactions:

Insoluble in water.

Reactive Group:

Amines, Phosphines, and Pyridines

Reactivity Profile:

IODOCHLOROHYDROXYQUINOLINE is incompatible with strong oxidizing agents, strong acids, acid chlorides and acid anhydrides (NTP, 1992). Darkens on exposure to light.

See More Clioquinol Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Skin irritation, Category 2

Skin sensitization, Category 1

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H315 Causes skin irritation H317 May cause an allergic skin reaction H319 Causes serious eye irritation
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P272 Contaminated work clothing should not be allowed out of the workplace.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P333+P317 If skin irritation or rash occurs: Get medical help. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Clioquinol cream should be stored in collapsible tubes or in tight, light-resistant containers. Topical preparations containing clioquinol should be stored at a temperature less than 30 deg C; freezing should be avoided.

See More Clioquinol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
South Africa	Clioquinol	1 KG	Apr 16, 2026

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