Colchicine powder

Colchicine

Acetamide,N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-;Colchicine;Acetamide,N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)-,(S)-;Benzo[a]heptalene,acetamide deriv.;N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide;NSC 757;(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide;Colchineos;Colchisol;Colcin;Colsaloid;Condylon;(-)-Colchicine;Colcrys;(S)-N-(1,2,3,10-Tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl)acetamide;Mitigare;5843-86-7;30512-31-3

64-86-8

C22H25NO6

InChIKey=IAKHMKGGTNLKSZ-INIZCTEOSA-N

399.43700

399.44

200-598-5

29399990

Coating Agent

83.09000

3.26250

Colchicine appears as odorless or nearly odorless pale yellow needles or powder that darkens on exposure to light. Used to treat gouty arthritis, pseudogout, sarcoidal arthritis and calcific tendinitis. (EPA, 1998)

1.32 g/cm3

142-150 °C

726.0±60.0 °C at 760 mmHg

392.9ºC

1.584

H2O: 45 g/L (20 ºC)

Poison room

3.2X10-11 mm Hg at 25 °C (est)

LD50 in rats (mg/kg): 1.6 i.v. (Rosenbloom, Ferguson); in mice (mg/kg): 4.13 i.v. (Beliles)

Specific optical rotation: -429 at 17 °C/D (water, 1.72%); -121 deg at 17 °C/d (concentration by volume = 0.9 g in 100 ml chloroform); max absorption (95% ethanol): 350.5 nm (log epsilon = 4.22), 243 nm (log epsilon = 4.47)

Odorless or nearly so

pH of 0.5% solution: 5.9

12.36None