High Quality Setmelanotide CAS NO.1294000-61-5
1294000-61-5
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
Yes
2024-01-24
CHEMICALS,REAGENTS
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Product Description
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Seller Information
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DescriptionBasic Info
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Product Name:
(4R)-4-(2-chloro-2,2-difluoroethyl)-1-{[2-(methoxymethyl)-6-(trifluoromethyl)imidazo[2,1-b][1,3,4]thiadiazol-5-yl]methyl}pyrrolidin-2-one
CAS No.:1294000-61-5
Molecular Formula:C14H14ClF5N4O2S
Exact Mass:432.045
Categories:
Characteristics-
PSA:
87.97
XLogP3:3.4641
Melting Point:83 °C
Research-
Class:
MC4R (melanocortin-4 receptor) agonist (8-amino-acid cyclic peptide)
Status:FDA-approved (Imcivree 2020) — orphan drug for genetic obesity
Mechanism:A first-in-class, 8-amino-acid cyclic peptide (Ac-Arg-cyclo[Cys-D-Ala-His-D-Phe-Arg-Trp-Cys]-NH2) that acts as a selective MC4R agonist. MC4R is a key regulator of hunger, satiety, and energy expenditure in the hypothalamus. Setmelanotide restores melanocortin signaling in patients with genetic defects in the leptin-melanocortin pathway, producing significant weight loss without cardiovascular side effects.
EC50 (Human Mc4r Ki):2.1 nM
EC50 (Human Mc4r Ec50):0.27 nM
Source:DrugBank: DB11700; ChemicalBook: CAS 920014-72-8; target validation: Chen C, et al.
Clinical Development:FDA:Imcivree (approved 2020-11-25)
References-
DrugBank:PubChem:Literature:
FDA: Imcivree (NDA 213793); NEJM: Clément K, et al. (2020) — Setmelanotide for POMC deficiency
Disclaimer:Setmelanotide is FDA-approved as a prescription medicine (Imcivree) for rare genetic forms of obesity (POMC/LEPR deficiency, Bardet-Biedl syndrome, Alström syndrome). This listing is for industrial and laboratory research use only. Research-chemical listings on B2B marketplaces are not interchangeable with approved medicines. Confirm CAS, specification, and regulatory pathway with the seller. It is not medical advice, a clinical recommendation, or an approved therapy description.
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Seller Information
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Business Type:
Trader
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Main Products:
CHEMICALS,REAGENTS
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Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2011
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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