High Quality Amiodarone hydrochloride CAS NO.19774-82-4
1 Inquiries
19774-82-4
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
2024-01-28
CHEMICALS,REAGENTS
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferenceWhite Solid
Amiodarone hydrochloride is an aromatic ketone.|Amiodarone Hydrochloride is the hydrochloride salt of an iodine-rich benzofuran derivative with antiarrhythmic and vasodilatory activities. As a class III antiarrhythmic agent, amiodarone blocks the myocardial calcium, potassium and sodium channels in cardiac tissue, resulting in prolongation of the cardiac action potential and refractory period. In addition, this agent inhibits alpha- and beta-adrenergic receptors, resulting in a reduction in sympathetic stimulation of the heart, a negative chronotropic effect, and a decrease in myocardial oxygen demands. Amiodarone may cause vasodilation by stimulation of the release of nitric oxide and cyclooxygenase-dependent relaxing endothelial factors.|An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
Amiodarone HCl (19774-82-4) is a nonselective ion channel blocker. Class III antiarrhythmic.1 Induces cytochrome c release and induces apoptosis.2 An alkalizing agent which stimulates progranulin (GRN) production and prevents GRN-dependent neurodegeneration.3 Induces autophagy and suppresses hepatocellular carcinoma tumorigenesis via autophagy-mediated MIR224 degradation in vitro and in vivo.4
ChEBI: Amiodarone hydrochloride is an aromatic ketone.
Amiodarone, marketed as Pacerone, Cordarone, Aratac, and Atlansil, is an antiarrhythmic agent monitored by clinical labs using HPLC or LCMS to ensure patients remain within the drugs therapeutic range.Basic Info-
Product Name:
Amiodarone hydrochloride
Other Name:2-BUTYL-3-BENZOFURANYL 4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYL KETONE HYDROCHLORIDE;(2-BUTYL-3-BENZOFURANYL)-[4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODO-PHENYL]-METHANONE HYDROCHLORIDE;AMIODARONE HYDROCHLORIDE;AMIODARONUM HYDROCHLORIDE;2-butyl-3-benzofuryl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl ketone hydrochloride;AMIODARONEHCL(2-BUTYL-3-BENZOFURANYL-4-[2-(DIETHYLAMINO)ETHOXY]-3,5-DIIODOPHENYLKETONE);ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl, hydamiodaronum hydrochloride;ketone, 2-butyl-3-benzofuranyl4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl, hydrochloride
CAS No.:19774-82-4
Molecular Formula:C25H29I2NO3.ClH
InChIKeys:ITPDYQOUSLNIHG-UHFFFAOYSA-N
Molecular Weight:681.77
Exact Mass:681.000366
EC Number:243-293-2
UNII:976728SY6Z
NSC Number:759560|85442
DSSTox ID:DTXSID7037185
NCI Thesaurus Code:C236
Color/Form:White
HScode:29322090
Categories:
Characteristics-
λmax:
242nm(MeOH)(lit.)
PSA:42.7
Density:1.58 g/cm3
Melting Point:154-158°C
Flash Point:9℃
Water Solubility:Soluble in chloroform, methanol.
Storage Conditions:2-8°C
Toxicity:dog,LD50,intravenous,5gm/kg (5000mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992.
PH:pH= 3.4 to 3.9 (5%) soln.
PKA:pKa (25°C) 6.56 ±0.06
Dissociation Constants:pKa = 6.56
Collision Cross Section:226.3 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:White to cream colored, crystalline powder and has solubilities of approx 0.72 mg/ml in water and 12.8 mg/ml in alcohol at 25 °C. The drug is highly lipophilic.
Critical Temperature & Pressure:2-8°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Dermal
Acute toxicity - Category 4, Inhalation
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H312 Harmful in contact with skin
H332 Harmful if inhaled
Precautionary statement(s) Prevention P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
Response P302+P352 IF ON SKIN: Wash with plenty of water/...
P317 Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Amiodarone should be stored at room temperature and protected from light and excessive heat. Light protection is not necessary upon adminitration.
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Seller Information
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Business Type:
Trader
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Main Products:
CHEMICALS,REAGENTS
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Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2011
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Inquiry History1 Inquiries
Country Product Purchase Quantity Date Posted 
Germany
Amiodarone Hydrochloride
1 20' Fcl Aug 11, 2026 Post an enquiry for this product
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