High quality Vemurafenib CAS NO.918504-65-1
918504-65-1
Pharmaceutical Grade
99%
shanghai
Lonwin
1kg/bag,25kg/drum,25kg/bag
Yes
2024-02-05
CHEMICALS,REAGENTS
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceVemurafenib is a novel and potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively.
Vemurafenib is a pyrrolopyridine that is 1H-pyrrolo[2,3-b]pyridine which is substituted at position 5 by a p-chlorophenyl group and at positions 3 by a 3-amino-2,6-difluorobenzoyl group, the amino group of which has undergone formal condensation with propane-1-sulfonic acid to give the corresponding sulfonamide. An inhibitor of BRAF and other kinases. It has a role as an antineoplastic agent and a B-Raf inhibitor. It is a pyrrolopyridine, a sulfonamide, a member of monochlorobenzenes, a difluorobenzene and an aromatic ketone.|Vemurafenib is a competitive kinase inhibitor with activity against BRAF kinase with mutations like V600E. It exerts its function by binding to the ATP-binding domain of the mutant BRAF. Vemurafenib was co-developed by Roche and Plexxikon and it obtained its FDA approval on August 17, 2011, under the company Hoffmann La Roche. After approval, Roche in collaboration with Genentech launched a broad development program.|Vemurafenib is a Kinase Inhibitor. The mechanism of action of vemurafenib is as a Protein Kinase Inhibitor, and Cytochrome P450 1A2 Inhibitor, and P-Glycoprotein Inhibitor.|Vemurafenib is a Kinase Inhibitor. The mechanism of action of vemurafenib is as a Protein Kinase Inhibitor.|Vemurafenib is a selective inhibitor of BRAF kinase that is used in the therapy of patients with metastatic and advanced malignant melanoma. Vemurafenib therapy is commonly associated with transient elevations in serum aminotransferase during therapy and has been linked to rare, but occasionally severe cases of clinically apparent acute liver injury.|Vemurafenib is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.|An indole sulfonamide compound and inhibitor of BRAF KINASES that is used for the treatment of unresectable or metastatic MELANOMA.Basic Info-
Product Name:
Vemurafenib
Other Name:1-Propanesulfonamide,N-[3-[[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-;N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;Vemurafenib;Ro 51-85426;RG 7204;PLX 4032;Zelboraf;Propane-1-sulfonic acid [3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl]amide;RO 5185426;1029872-54-5;1652573-83-5
CAS No.:918504-65-1
Molecular Formula:C23H18ClF2N3O3S
InChIKeys:InChIKey=GPXBXXGIAQBQNI-UHFFFAOYSA-N
Molecular Weight:489.9221264
Exact Mass:489.92
UNII:207SMY3FQT
NSC Number:761431
DSSTox ID:DTXSID50238710
NCI Thesaurus Code:C64768
Color/Form:White to off-white crystalline solid
ATC Code:L01EC01|L01XE15|L - Antineoplastic and immunomodulating agents
HScode:2935009090
Categories:
Characteristics-
PSA:
100
XLogP3:5
Density:1.46
Melting Point:272°C
Flash Point:384.0±35.7 °C
Refractive Index:1.653
Water Solubility:H2O: <1 mg/mL;Practically insoluble in aqueous media
Storage Conditions:Store at room temperature 20 deg C - 25 degC (68 deg F - 77 deg F); excursions permitted between 15 deg C and 30 deg C (59 deg F and 86 deg F), See USP Controlled Room Temperature. Store in the original container with the lid tightly closed.
Vapor Pressure:8.21X10-15 mm Hg at 25 deg C (est)
PKA:7.1None
Henrys Law Constant:Henry's Law constant = 1.23X10-17 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.1|pKa = 7.2 (amine) (est)
Hazard IdentificationClassification of the substance or mixture
Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Warning
Hazard statement(s) H410 Very toxic to aquatic life with long lasting effects
Precautionary statement(s) Prevention P273 Avoid release to the environment.
Response P391 Collect spillage.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Trader
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Main Products:
CHEMICALS,REAGENTS
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Location:
No 966 Huaxu Road, Qingpu District, Shanghai, 201702, P.R. China
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Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10 days
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Total Annual Revenue:
$10 million-$25 million
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Total Employees:
11-50
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Year of Establishment:
2011
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Country Product Purchase Quantity Date Posted Post an enquiry for this product
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