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Home > Pharmaceutical Intermediates > Bulk Drug Intermediates > ODM-201 for Sale > Darolutamide CAS 1297538-32-9 Potent Androgen Receptor Antagonist for Prostate Cancer Research fk
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Darolutamide CAS 1297538-32-9 Potent Androgen Receptor Antagonist for Prostate Cancer Research fk

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Unit Price:

$100-130/G FOB

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CAS No.:

1297538-32-9

Grade:

Reagent Grade

Content:

99%

Port:

qingdao

Brand:

//

Packaging:

5g, 25g, 100g, 500g

Sample Available:

Yes

Price valid (until):

2026-10-16

Company Type:
Trader
Location:
China
Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

  • Product Description

  • Seller Information

  • Description

    —— Product Specification ——

    Parameter Specification Details
    Product Name Darolutamide ODM-201; BAY-1841788; Nubeqa
    CAS Number 1297538-32-9 1297538-32-9
    Molecular Formula C₁₉H₁₉ClN₆O₂ 19 carbons, 19 hydrogens, 1 chlorine, 6 nitrogens, 2 oxygens
    Molecular Weight 398.85 g/mol —
    Appearance White to off-white solid powder Visual inspection
    Purity ≥98.0% Determined by HPLC
    Target Androgen Receptor (AR) Non-steroidal antagonist
    IC₅₀ 26 nM AR antagonism
    Ki 11 nM AR binding affinity
    Solubility DMSO: ≥60 mg/mL —
    Storage Powder: -20°C for 3 years, 4°C for 2 years; In solvent: -80°C for 6 months, -20°C for 1 month Protect from light and moisture
    Packaging 10mg, 25mg, 50mg, 100mg, 500mg Amber glass vials
    Application Research use only Prostate cancer research, AR inhibition studies


    —— Product Detail ——

    Product Overview

    • Darolutamide (CAS 1297538-32-9), also known as ODM-201 or BAY-1841788 and marketed under the brand name Nubeqa, is a potent, orally active, non-steroidal androgen receptor (AR) antagonist developed by Bayer and Orion Corporation . It appears as a white to off-white solid powder with the molecular formula C₁₉H₁₉ClN₆O₂ and a molecular weight of 398.85 g/mol 


    Packaging & Shipping

                  • Research quantities: 5mg, 10mg, 25mg amber glass vials

                  • Bulk quantities: 50mg, 100mg amber glass bottles

                  • Custom packaging available upon request

                  • Not classified as hazardous material for transport under normal conditions

                  • Product for research and analytical use only; not for human therapeutic use

    Shop CAS 18048-64-1 Eltrombopag Intermediate for Pharmaceutical Research  kr-Detailed Image 1

    — Company profile ——


     Shop CAS 1231930-42-9 Abemaciclib Intermediate for Pharma researech use KR-Detailed Image 1

    Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

    Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

    We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

    To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

    Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

     

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    —— Q&A ——

    Q1: How to confirm the product quality before placing orders?
    A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

    Q2: Can you supply free samples?
    A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

    Q3: How do you treat quality complaints?
    A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

    Q4: What is your MOQ? Is there a discount?
    A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
    Q: Is there a discount?
    A: Yes, for larger quantities, we always support with better prices.

    Q5: How to start orders or make payments?
    A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.



    ECHEMI Editorial Reference
    ODM-201 is a novel androgen receptor (AR) inhibit designed to inhibit the growth of prostate cancer cells through binding to the AR to inhibit the testosterone-induced AR nuclear translocation. It is particularly used in patients with progressive metastatic castration-resistant prostate cancer. It is effective in inhibiting the activity of some mutant ARs emerging during antiandrogen therapies, including the F876L mutation version which is resistant to enzalutamide and ARN-509 (the second-generation antiandrogens).Therefore, it has potential to overcome the resistance issue occurring upon AR-targeted therapies.
    ODM-201 is an androgen receptor (AR) antagonist (Ki= 11 nM). It inhibits AR transactivation in U2OS osteosarcoma cells expressing human wild-type and mutant ARs (IC50s = 65, 66, 1,500, and 1,782 nM for wild-type, ARF876L, ARW741L, and ART877A, respectively). ODM-201 prevents androgen-induced AR nuclear translocation in AR-overexpressing HS-HEK293 and LNCaP cells and suppresses androgen-induced proliferation of VCaP cells (IC50= 230 nM).In vivo, ODM-201 (50 mg/kg per day) reduces tumor growth in a VCaP castrated mouse xenograft model. It also inhibits tumor growth without increasing serum testosterone levels in a VCaP intact mouse xenograft model.

    Certificates
    • Darolutamide CAS 1297538-32-9 Potent Androgen Receptor Antagonist for Prostate Cancer Research fk Certificates 1 TDS

    Basic Info
    Product Name:

    ODM-201

    Other Name:

    CS-1565;N-{(2S)-1-[3-(3-chloro-4-cyanophenyl)-1H-pyrazol-1-yl]propan-2-yl}-5-[(1RS)-1-hydroxyethyl]-1H-pyrazole-3-carboxamide;0DM021;BAY-1841788;ODM-021;0DM021;ODM 021;ODM 021;ODM-021;ODM-201;N-[(1S)-2-[3-(3-Chloro-4-cyanophenyl)-1H-pyrazol-1-yl]-1-methylethyl]-5-(1-hydroxyethyl)-1H-pyrazole-3-carboxamide

    CAS No.:

    1297538-32-9

    Molecular Formula:

    C19H19ClN6O2

    InChIKeys:

    BLIJXOOIHRSQRB-PXYINDEMSA-N

    Molecular Weight:

    398.85

    EC Number:

    829-313-8

    Color/Form:

    White to Off-White

    Characteristics
    Density:

    1.41±0.1 g/cm3(Predicted)

    Melting Point:

    169 - 171°C

    Boiling Point:

    719.5±60.0 °C(Predicted)

    PKA:

    11.10±0.10(Predicted)

    Critical Temperature & Pressure:

    -20°C Freezer, Under inert atmosphere

  • Seller Information
    Business Type:

    Trader

    Main Products:

    Medetomidine,Medetomidine hydrochloride,D-Lysergic Acid Methyl Ester,SR17018,Fluralaner,GS-441524

    Location:

    RONGSHENG BEIYUANDAJIE 9, LICHENG DISTRICT,JINAN, SHANDONG CHINA

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    $1 million-$2.5 million

    Total Employees:

    11-50

    Year of Establishment:

    2022

    Jinan Topfull Chemical Co., Ltd. is a global chemical Industrial and focuses on advanced chemical technology. Specialized in Cosmetic materials, water treatment, fine chemicals and so on. We are looking forward to working together with the people of all circles at home and abroad to seek common development!
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