High purity supply Adipotide FTPP peptide

adipotide,ftpp, peptide

Polypeptide

Chimeric peptidomimetic (fat-targeting vascular disruptor)

Research compound — Not FDA approved, clinical development discontinued

A synthetic chimeric peptide composed of a fat-vascular-targeting cyclic peptide (CKGGRAKDC) linked via a GG spacer to a pro-apoptotic peptide (KLAKLAK)2. Adipotide selectively binds prohibitin in the vasculature of white adipose tissue, then delivers the pro-apoptotic domain to induce vascular disruption, causing fat tissue death. In primate studies (2011), it produced significant weight loss (~11%) but also caused renal toxicity, leading to development discontinuation.

Adipotide is not a receptor agonist. It functions as a targeted vascular disruptor. Functional activity is measured by tissue-specific apoptosis, not traditional EC50.

PubChem: Adipotide (CID 163360068); Kolonin MG, et al. Sci Transl Med. 2004;6(148):148ra16.DOI

PubChem

Sci Transl Med: Kolonin MG, et al. (2004) — Adipotide mechanism; ChemicalBook: Adipotide (CAS 859216-15-2)

Adipotide is NOT FDA-approved or EMA-approved. It is a research compound only. Clinical development was discontinued due to renal toxicity observed in primate studies. This listing is for industrial and laboratory research use only. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.