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Supply: High Quality 99% CAS 65277-42-1 Ketoconazole

Name: Supply: High Quality 99% CAS 65277-42-1 Ketoconazole
Brand: COMINGS
SKU: pr2403191107
Price: 165.89 USD
Availability: InStock

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CAS No.:

65277-42-1

Grade:

Ketoconazole Description

CAS	65277-42-1	Name	Ketoconazole
Purity	99%	Synonyms	Ketoconazole
Molecular formula	C₂₆H₂₈Cl₂N₄O₄	Molecular Weight	531.431
Shelf Life	2 Years	Package	25kg,10kg,5kg,1kg

Ketoconazole, also known as ketoconazole, is a type of imidazole antifungal medication widely used to treat various fungal infections, including candidiasis and dermatophytosis. Its mechanism of action primarily involves inhibiting the synthesis of fungal cell membranes, thereby disrupting the growth and reproduction of fungi.

What sets this medication apart is that it is not only an antifungal agent but is also considered a classic CYP3A4 inhibitor. CYP3A4 is a cytochrome P450 enzyme found in the liver and intestines, responsible for metabolizing a variety of drugs and compounds. As a CYP3A4 inhibitor, ketoconazole can impact the metabolism of other drugs in the body, leading to increased concentrations and influencing their efficacy and side effects.

Furthermore, ketoconazole has been identified as an inhibitor of CYP24A1. CYP24A1 is a cytochrome P450 enzyme involved in vitamin D metabolism. By inhibiting CYP24A1, ketoconazole may affect the metabolism and regulation of vitamin D. This discovery has garnered attention in research related to diseases associated with vitamin D metabolism.

Pharmacologically, the multifaceted mechanisms of action of ketoconazole make it versatile in clinical applications. However, caution is necessary, especially when co-administered with other drugs, as its inhibition of CYP3A4 can lead to drug interactions, impacting the safety and effectiveness of medications.

In conclusion, the diverse pharmacological actions of ketoconazole make it a crucial antifungal medication, providing a broad spectrum of applications in clinical settings. As our understanding of the drug's mechanisms deepens, we can better leverage its advantages, potentially achieving breakthroughs in the field of drug therapy.

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Wuhan Comings Biotechnology Co., Ltd. was established in 2016. Since its establishment, the company has always been committed to making more people healthy, making more people young and happy, and providing customers with high-quality and efficient services.

The company cooperates with biological experts from many universities, adopts modern gene cloning technology and unique purification technology, and strictly controls all aspects. The adipotide we produce are sold well in Europe, Africa, and America, and many customers have given good reviews.

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Certificates

Basic Info

Product Name:

Ketoconazole

Other Name:

Ethanone,1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]-,rel-;Piperazine,1-acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,cis-;Piperazine,1-acetyl-4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-,rel-;rel-1-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanone;Ketoconazole;R 41400;Nizoral;(±)-Ketoconazole;Fungoral;Nizral;Orifungal M;Ketoderm;Panfungol;Ketoisdin;Fungarest;Brizoral;Onofin K;Ketozoral;Phytorol;Tocon;Nizaral;Micosin;72093-26-6

CAS No.:

65277-42-1

UN No.:

2811

Molecular Formula:

C26H28Cl2N4O4

InChIKeys:

InChIKey=XMAYWYJOQHXEEK-MKNUCDGGNA-N

Molecular Weight:

531.43100

Exact Mass:

531.43

HScode:

2933990090

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

69.06000

XLogP3:

4.20870

Appearance:

white to off white crystalline powder

Density:

1.38g/cm3

Melting Point:

146 °C

Boiling Point:

753.4ºC at 760 mmHg

Flash Point:

409.4ºC

Refractive Index:

1.642

Water Solubility:

Soluble in DMSO, ethanol, chloroform, water, and methanol.

Storage Conditions:

2-8ºC

Toxicity:

LD50 in mice, rats, guinea pigs, dogs (mg/kg): 44, 86, 28, 49 i.v.; 702, 227, 202, 780 orally (Heel)

See More Ketoconazole Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 3, Oral

Specific target organ toxicity â repeated exposure, Category 2

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H301 Toxic if swallowed H373 May cause damage to organs through prolonged or repeated exposure H410 Very toxic to aquatic life with long lasting effects
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P273 Avoid release to the environment. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P319 Get medical help if you feel unwell. P391 Collect spillage. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Well closed. Separated from food and feedstuffs. Store in an area without drain or sewer access.Store at controlled room temperature 15 deg - 25 deg C (59 deg - 77 deg F). Protect from moisture.

See More Ketoconazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
semaglutide,tirzepatide,Liraglutide,Retatrutide,5-amino-1MQ,SLU-PP-332

Location:
No. 1, 19th Floor, Unit 2, Building 5, Southeast Residential Building (Hankou Yujiang Lanting), at the intersection of Hanshi Highway and Fufa South Road, Wuhu Street, Huangpi District, Wuhan City, Hu

Payment Terms:
TT against copy of documents,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Total Employees:
11-50

Year of Establishment:
2023

We prospectively allocates international cutting-edge production and testing equipment and environmental protection facilities. The 5 production lines can achieve an annual output of 1000Kg. We to be the best chemical manufacture in China,and will become a trustworthy supplier of chemicals for global customers.
Our main products include peptides, cognitive enhancers, pharmaceutical intermediates, and botanical extracts.
And our main clients cover: pharmaceutical companies, hospitals, laboratories in higher education institutions, and cosmetic companies.
Since its establishment, our company's products have been exported to regions including Europe, the Americas, the Middle East and so on. Our commitment to high product quality and excellent after-sales service has provided customers with a positive experience.
Wuhan Comings Biotechnology Co., Ltd. is looking forward to cooperating with you with professional knowledge, high-quality service and competitive price!

Inquiry History

23 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	KETOCONAZOLE	50 KG	Dec 25, 2024
United Kingdom	Ketoconazole	1 KG	May 31, 2026
Sri Lanka	Ketoconazole Powder	10 KG	Feb 20, 2025
United Kingdom	99% Raw Pharmaceutical Raw Material Ketoconazole for Shampoo Nizoral	1 KG	Aug 31, 2024
India	ketoconazol	500 KG	Feb 6, 2024
Poland	Ketoconazole	10 KG	Oct 9, 2023
Sri Lanka	Ketakenazole	1 KG	Mar 18, 2026
United States	ketoconazole	100 KG	Oct 24, 2025
Pakistan	Ketoconazole	1 KG	Jul 3, 2025
Bangladesh	Ketoconazole	1 KG	Nov 27, 2024
New Zealand	Ketoconazole 99% powder	2 KG	Oct 2, 2024
Ecuador	Ketoconazol	0.50 KG	Jul 26, 2024
Australia	Ketoconazole	1 MT	May 27, 2024
Cameroon	Ketoconazole powder 99% white wholesale	1 KG	Feb 5, 2024
Sri Lanka	Ketoconazole powder 99% White Powder	10 KG	Nov 6, 2023
Paraguay	Almidon pre-gelatinizado	300.00 KG	Dec 1, 2025
Paraguay	Ceftiofur hcl	25.00 KG	Dec 1, 2025
Paraguay	Dichloromethane	5000.00 KG	Dec 1, 2025
Paraguay	Pyrantel pamoate	75.00 KG	Dec 1, 2025
Paraguay	Azepromacine maleate	12.00 KG	Dec 1, 2025

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Supply: High Quality 99% CAS 65277-42-1 Ketoconazole

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