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Imidazole288-32-4

Name: Imidazole288-32-4
Brand: OORENT
SKU: pr2609241066
Price: 33 USD
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$33-34/MT FOB

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CAS No.:

288-32-4

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

SHANGHAI

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Sample Available:

Yes

Price valid (until):

2026-10-24

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Payment Terms:

100% TT in advance

Average Lead Time:

10 days

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

Product Detail

Imidazole Basic information

Product Name:	Imidazole
Synonyms:	1,3-DIAZA-2,4-CYCLOPENTADIENE;LABOTEST-BB LTBB001344;IMIDAZOLE;GLYOXALIN;GLYOXALINE BUFFER;N,N'-VINYLENEFORMAMIDINE;AKOS BBS-00004265;imidazole buffer solution
CAS:	288-32-4
MF:	C3H4N2
MW:	68.08
EINECS:	206-019-2
Product Categories:	API;Pharmaceutical intermediates;Highly Purified Reagents;Other Categories;Zone Refined Products;Buffer;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;Biochemistry;Reagents for Oligosaccharide Synthesis;ACS Grade Buffers;ACS Grade;Biological Buffers;Buffers A to Z;Intermediate for Propafenone hydrochloride.;Building Blocks;C3 to C8;Chemical Synthesis;Essential Chemicals;Heterocyclic Building Blocks;Imidazoles;Inorganic Salts;Research Essentials;Solutions and Reagents;2-8°C;288-32-4;3;bc0001;T0001
Mol File:	288-32-4.mol

Imidazole Chemical Properties

Melting point	88-91 °C(lit.)
Boiling point	256 °C(lit.)
density	1.01 g/mL at 20 °C
bulk density	500-600kg/m3
vapor pressure	<1 mm Hg ( 20 °C)
refractive index	1.4801
Fp	293 °F
storage temp.	Store below +30°C.
solubility	H₂O: 0.1 M at 20 °C, clear, colorless
pka	6.953(at 25℃)
form	crystalline
color	white
Specific Gravity	1.03
Odor	Amine like
PH Range	9.5 - 11
PH	9.5-11.0 (25℃, 50mg/mL in H2O)
Water Solubility	633 g/L (20 ºC)
Sensitive	Hygroscopic
λmax	λ: 260 nm Amax: 0.10 λ: 280 nm Amax: 0.10
Merck	14,4912
BRN	103853
Henry's Law Constant	3.3×10³ mol/(m³Pa) at 25℃, Du et al. (2017)
Dielectric constant	23.0(Ambient)
Stability:	Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.
Cosmetics Ingredients Functions	BUFFERING
InChI	1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChIKey	RAXXELZNTBOGNW-UHFFFAOYSA-N
SMILES	c1c[nH]cn1
LogP	-0.02 at 25℃
CAS DataBase Reference	288-32-4(CAS DataBase Reference)
NIST Chemistry Reference	1H-Imidazole(288-32-4)
EPA Substance Registry System	Imidazole (288-32-4)

Safety Information

Hazard Codes	C,Xi,T
Risk Statements	36/38-63-34-22-20/21/22-61
Safety Statements	26-36/37/39-45-22-36-27-53
RIDADR	UN 2923 8/PG 3
WGK Germany	1
RTECS	NI3325000
Autoignition Temperature	480 °C
TSCA	TSCA listed
HazardClass	8
PackingGroup	III
HS Code	29332990
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Repr. 1B Skin Corr. 1C
Hazardous Substances Data	288-32-4(Hazardous Substances Data)
Toxicity	LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie)

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English
ALFA	English

Imidazole Usage And Synthesis

Description	Imidazole group denotes a heterocyclic organic compound whose molecule contains a five-membered hetero-aromatic ring of two non-adjacent nitrogen atoms, that a carbon atom is placed between two nitrogen atoms. Imidazole is the universally used trivial name for 1,3-azole. Earlier given names were glyoxaline and iminazole. The importance of this aromatic ring system is reflected by its presence in naturally occurring histidine, histamine and the purines, and in several classes of pharmaceuticals. Imidazole can act as a base and as a weak acid. It exists in two tautomeric forms with the hydrogen atom taking position between the two nitrogen atoms.
Chemical Properties	Imidazole is a moderately strong base (pKb= 7.0), and a weak acid (pKa= 14.9). Imidazoles substituted with electron-withdrawing groups are stronger acids than imidazole itself; e.g., 4(5)-nitroimidazole has a pKa of 9.3. Imidazole is stable at 400°C, possesses considerable aromatic character, and undergoes the usual electrophilic aromatic substitution reactions. Nitration and sulfonation require, however, far more drastic conditions than the corresponding reactions with benzene. Other substitution reactions of imidazole include halogenation, hydroxymethylation, coupling with aromatic diazonium salts, and carboxylation.
History	Imidazole[288-32-4] was first synthesized in 1858 by Debus from ammonia and glyoxal; it was originally named glyoxalin. The name imidazole was introduced by Hantzsch. Industrial production of imidazole began in the 1950s; a wide range of derivatives is now available in industrial quantities.
Uses	Imidazole is used as a buffer in the range of pH 6.2-7.8. It is also an histamine antagonist. It acts as a chelator and forms complexes with various divalent cations. It is used as a corrosion inhibitor on certain transition metals such as copper. Its derivatives, like polybenzimidazole (PBI), act as fire retardants. It finds application in photography and electronics. Imidazole salts are used as ionic liquids and precursors to stable carbenes. Imidazole derivatives like ketoconazole, miconazole and clotrimazole are involved in the treatment of various systemic fungal infections. It is a part of the theophylline molecule, present in tea leaves and coffee beans, which stimulates the central nervous system.
Application	Imidazole is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used ext ensively as a corrosion inhibitor on transition metals such as copper.It is used in organic synthesis and as an antiirradiationagent. Imidazole has been used: in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein. in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography. as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cell.
Preparation	Imidazole is formed by reacting glyoxal with formaldehyde in the presence of ammonium acetate in acetic acid. The driving energy is microwave radiation. More generally, this reaction is used to produce substituted imidazoles. Although there had been discoveries of various derivatives of imidazole in 1840, it was first reported in 1858. The synthesis process of imidazole follows the reaction between formaldehyde in ammonia and glyoxal. This process gives low yield of imidazole but it is still used to form imidazole with C-substitution (Wolkenberg et al., 2004).
Definition	ChEBI: Imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. It is an important pharmacophore in drug discovery. Imidazole is used as a Karl Fischer reagent in analytical chemistry and a reagent in synthetic organic chemistry.
General Description	Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.
Health Hazard	It is less toxic relative to pyrrole and otherfive-membered heterocyclic compounds ofnitrogen. Intraperitoneal administration ofimidazole caused somnolence, muscle contractions,and convulsions in mice. Theoral LD50 value in mice is in the range900 mg/kg.
Fire Hazard	Noncombustible solid.
Biochem/physiol Actions	Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
Mechanism of action	N-substitution of imidazoles has created a family of drugs, called triazoles, that have the same mechanism of action as imidazoles, a similar or broader spectrum of activity, and less effect on human sterol synthesis. Both imidazoles and triazoles inhibit C-14α demethylation of lanosterol in fungi by binding to one of the cytochrome P-450 enzymes, which leads to the accumulation of C-14α methylsterols and reduced concentrations of ergosterol, a sterol essential for a normal fungal cytoplasmic membrane. Inhibition of cytochrome P-450 also decreases the synthesis of testosterone and glucocorticoids in mammals, an effect seen clinically with ketoconazole but not with later azoles[1].
Purification Methods	Crystallise imidazole from benzene, CCl4, CH2Cl2, EtOH, pet ether, acetone/pet ether and distilled de-ionized water. Dry it at 40o under vacuum over P2O5. Distil it at low pressure. It is also purified by sublimation or by zone melting. [Snyder et al. Org Synth Coll Vol III 471 1955, Bredereck et al. Chem Ber 97 827 1964, Caswell & Spiro J Am Chem Soc 108 6470 1986.] 15N-imidazole crystallises from benzene [Scholes et al. J Am Chem Soc 108 1660 1986]. [Beilstein 23 II 34, 23 III/IV 564, 23/4 V 191.]
References	[1] Rex, J. and D. Stevens. “39 – Drugs Active against Fungi, Pneumocystis, and Microsporidia.” Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases 23 1 (2015): 479-494.

Imidazole Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Potassium hydroxide-->Ammonium hydroxide-->Hydrogen peroxide-->Ammonium chloride-->Formaldehyde-->o-Phenylenediamine-->Glyoxal-->Cupric oxide-->Benzimidazole-->4,5-Imidazoledicarboxylic acid

Preparation Products

5-(Aminomethyl)-1-methylpyrrolidin-2-one-->(S)-4-Boc-morpholine-3-carboxylic acid-->1-Boc-3-(Amino)azetidine-->beta-Methyl vinyl phosphate (MAP)-->6-Fluoro-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile-->1-Methylimidazole-->5-bromo-1H-indazole-->6-Fluoro-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid-->2-Cyanopyridine-4-carboxaldehyde-->Imazalil-->4-(Hydroxymethyl)picolinitrile-->2-(1H-Imidazol-1-yl)benzoic acid-->Clotrimazole-->Econazole-->Miconazole nitrate-->Sisthsne-->Ketoconazole-->1-[4-(Bromomethyl)phenyl]-1H-pyrazole-->Imidazole-2-carboxaldehyde-->Xanthine-->4-Chloroimidazole-->4-(Imidazol-1-yl)phenol-->2-Bromo-4-nitroimidazole-->Oxiconazole nitrate-->TRIFLUMIZOLE-->1-Benzyl-2-imidazolecarboxylic acid-->1-Phenylimidazole-->4-(1H-Imidazol-1-yl)benzaldehyde-->2-Imidazol-1-ylethanamine-->N-(3-Aminopropyl)-imidazole-->4-(1H-Imidazol-1-yl)benzoic acid-->Climbazole-->Orazamide-->1-[(4-Methylphenyl)sulfonyl]-1H-imidazole-->imidazol-2-ylamine sulphate-->1-(1-2-Hydroxyphenyl)ethenyl)-1H-imidazole-->chloroalcohol type homogeneous strongly basic anion exchange membrane-->1-Methyl-5-nitroimidazole-->4-Nitroimidazole-->Detergent,industrial

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ECHEMI Editorial Reference

Imidazole is a planar 5-membered ring. Imidazole is a highly polar compound. Imidazole has been used extensively as a corrosion inhibitor.Imidazole is incorporated into many important biological molecules. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Imidazole is useful as a buffer in the pH range of 6.2-7.8 One of the applications of imidazole is in the purification of His-tagged proteins in immobilised metal affinity chromatography(IMAC). Imidazole
Imidazole is a versatile heterocycle used in the preparation of various biologically active compounds such as the amino acid histidine and is present in many antifungal medication. It is also used extensively as a corrosion inhibitor on transition metals such as copper.
OtherSolid|Solid|COLOURLESS-TO-YELLOW CRYSTALS WITH CHARACTERISTIC ODOUR.
1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole.

Basic Info

Product Name:

Imidazole

Other Name:

1H-Imidazole;Imidazole;1,3-Diaza-2,4-cyclopentadiene;1,3-Diazole;Glyoxalin;Glyoxaline;Imidazol;Imutex;Miazole;Methanimidamide,N,N′-1,2-ethenediyl-;NSC 60522;3-Azapyrrole;Curezol SIZ;116421-26-2;146117-15-9

CAS No.:

288-32-4

Molecular Formula:

C3H4N2

InChIKeys:

InChIKey=RAXXELZNTBOGNW-UHFFFAOYSA-N

Molecular Weight:

68.07730

Exact Mass:

68.08

EC Number:

206-019-2

UNII:

7GBN705NH1

ICSC Number:

1721

NSC Number:

60522

UN Number:

3263

DSSTox ID:

DTXSID2029616

Color/Form:

Monoclinic prisms from benzene|Colorless crystals|Colorless-yellow solid

HScode:

2933990090

Categories:

Fungicides

Characteristics

PSA:

28.68000

XLogP3:

-0.1

Appearance:

OtherSolid

Density:

1.036 g/cm³ @ Temp: 95.0 °C

Melting Point:

90.5 °C

Boiling Point:

257 °C

Flash Point:

145ºC

Refractive Index:

1.4801

Water Solubility:

H2O: 633 g/L (20 ºC)

Storage Conditions:

2-8ºC

Vapor Pressure:

<1 mm Hg ( 20 °C)

Vapor Density:

Relative vapour density (air = 1): 2.35

Toxicity:

LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie)

Odor:

Amine-like odor

PH:

pH 10.5 for 38 g/L at 20 °C

PKA:

6.95(at 25 °C)

OH:

3.59e-11 cm3/molecule*sec

Henrys Law Constant:

Henry's Law constant = 3.8X10-6 atm-cu m/mol at 25 °C (est; for the neutral species)

Dissociation Constants:

6.95 (at 25 °C)|pK 6.92 at 25 °C (weak base)|Imidazole is a moderately strong base pKb = 7.0, and a weak acid pKa = 14.9|Imidazole is a heterocyclic compound containing two nitrogen atoms with pKa = 7.0 and pKa = 14.9

Experimental Properties:

Viscosity: 2.696 mPa sec at 100 °C|Molar heat capacity Cp (gas) = 71.3 J/mol K|Enthalpy of formation (crystal) = 49.8 kJ/mol|Enthalpy of fusion = 12.96 kJ/mol|For more Other Experimental Properties (Complete) data for Imidazole (7 total), please visit the HSDB record page.

Autoignition Temperature:

480 °C

Physical Dangers:

Dust explosion possible if in powder or granular form, mixed with air.

See More Imidazole Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin corrosion, Sub-category 1C

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H302 Harmful if swallowed H314 Causes severe skin burns and eye damage
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P260 Do not breathe dust/fume/gas/mist/vapours/spray. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P301+P330+P331 IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P363 Wash contaminated clothing before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Closed system, dust explosion-proof electrical equipment and lighting. Prevent deposition of dust. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Separated from strong acids and food and feedstuffs.

See More Imidazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

7 Inquiries

Country	Product	Purchase Quantity	Date Posted
New Zealand	Imidazole	1 KG	May 31, 2026
India	Imidazole	800	Mar 18, 2026
India	Imidazole	50 MT	Nov 17, 2025
India	IMIDAZOLE	10 MT	Aug 11, 2025
United Kingdom	Imidazole	1000 MT	Sep 30, 2025
India	imidazole	16 MT	Dec 16, 2023
Romania	imidazole	75 KG	Sep 23, 2026

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Imidazole288-32-4

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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