Lomustine
ISO
13010-47-4
Industrial Grade
98%
25kg/Cardboard Drum
2024-04-19
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Product Description
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Seller Information
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DescriptionECHEMI Editorial ReferenceLomustine is a pale yellow powder. ChEBI: An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in he treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.Lomustine is available in 10-, 40-, and 100-mg capsules fororal administration in the treatment of primary and metastaticbrain can
Solid
Lomustine is an N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours. It has a role as an alkylating agent and an antineoplastic agent. It is a member of N-nitrosoureas and an organochlorine compound.|An alkylating agent of value against both hematologic malignancies and solid tumors.|Lomustine is an Alkylating Drug. The mechanism of action of lomustine is as an Alkylating Activity.|Lomustine is an orally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several malignancies including Hodgkin disease, lymphoma, and brain cancer. Lomustine therapy is associated with minor transient serum enzyme elevations and has been linked to rare cases of clinically apparent acute liver injury.|Lomustine is a nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)CertificatesBasic Info-
Product Name:
Lomustine
Other Name:Urea,N-(2-chloroethyl)-N′-cyclohexyl-N-nitroso-;Urea,1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-;N-(2-Chloroethyl)-N′-cyclohexyl-N-nitrosourea;3-Cyclohexyl-1-(2-chloroethyl)-1-nitrosourea;CCNU;1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea;Lomustine;NSC 79037;1-(2-Chloroethyl)-3-cyclohexylnitrosourea;ICIG 1109;Belustine;1-(2-Chloroethyl)-1-nitroso-3-cyclohexylurea;Lomustin;CeeNU;CiNu;Chloroethylcyclohexylnitrosourea;SRI 2200;Cecenu;NCI C04740;RB 1509;Lustine;Moostine;Lomtin
CAS No.:13010-47-4
Molecular Formula:C9H16ClN3O2
InChIKeys:InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Molecular Weight:233.7
Exact Mass:233.70
EC Number:235-859-2
UNII:7BRF0Z81KG
NSC Number:759635|79037
DSSTox ID:DTXSID2023222
NCI Thesaurus Code:C617
Color/Form:Solid|Yellow powder
ATC Code:L - Antineoplastic and immunomodulating agents
HScode:29299090
Categories:
Characteristics-
PSA:
61.8
XLogP3:2.8
Appearance:Solid
Density:1.3840 (rough estimate)
Melting Point:89 °C (approx)
Boiling Point:63.6°C (rough estimate)
Refractive Index:1.5790 (estimate)
Water Solubility:7.55e-01 g/L
Storage Conditions:−20°C
Vapor Pressure:1.01X10-5 mm Hg at 25 deg C (est)
Toxicity:Oral-Rat LD50: 70 mg/kg; Oral-Mouse LD50:38 mg/kg
Flammability characteristics:Flammable; decomposes toxic chloride and nitrogen oxide gas in the fire
Henrys Law Constant:Henry's Law constant = 1.9X10-10 atm-cu m/mole at 25 °C (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 2.2X10-11 cu cm/molecule-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Carcinogenicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H350 May cause cancer
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 deg C. Light sensitive.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Dyes,Textile agent,Medical intermediate,API,Pigments,Basic Chemicals
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Location:
Room 507, Dongnan Technology R&D Center, No.438 Jincheng Road, Beigan Street, Xiaoshan District,Hangzhou City,Zhengjiang Province,China
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Payment Terms:
TT against copy of documents,L/C,100% TT in advance
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Average lead Time:
20
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Total Annual Revenue:
$25 million-$50 million
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Total Employees:
51-100
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Year of Establishment:
2013
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Country Product Purchase Quantity Date Posted Post an enquiry for this product






