SECTION 1: Identification
1.1GHS Product identifier
| Product name | 2-ethoxyethanol |
1.2Other means of identification
| Product number | - |
| Other names | 2-hydroxyethyl ethyl ether; EGEE; 2-ethoxy-ethanol |
1.3Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
Flammable liquids, Category 3
Acute toxicity - Category 4, Oral
Acute toxicity - Category 3, Inhalation
Reproductive toxicity, Category 1B
2.2GHS label elements, including precautionary statements
| Pictogram(s) |    |
| Signal word | Danger |
| Hazard statement(s) | H226 Flammable liquid and vapour H302 Harmful if swallowed H331 Toxic if inhaled |
| Precautionary statement(s) |
| Prevention | P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. |
| Response | P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P318 IF exposed or concerned, get medical advice. |
| Storage | P403+P235 Store in a well-ventilated place. Keep cool. P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up. |
| Disposal | P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal. |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| 2-ethoxyethanol | 2-ethoxyethanol | 110-80-5 | 203-804-1 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower. Refer for medical attention .
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
4.2Most important symptoms/effects, acute and delayed
Some eye irritation. Inhalation of vapors causes irritation of nose. (USCG, 1999)
4.3Indication of immediate medical attention and special treatment needed, if necessary
Emergency and supportive measures. 1. Maintain an open airway and assist ventilation if necessary. Administer supplemental oxygen. 2. Treat coma, convulsions, cardiac arrhythmia and metabolic acidosis if they occur. Observe the patient for several hours to monitor for development of metabolic acidosis, especially if the patient is symptomatic or there is a known co-ingestion of ethanol. 3. Treat hypocalcemia with intravenous calcium gluconate or calcium chloride. Ethylene glycol and other glycols
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped or safely confined. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.
5.2Specific hazards arising from the chemical
Special Hazards of Combustion Products: Toxic gases, such as carbon monoxide, may be produced in fire. (USCG, 1999)
5.3Special protective actions for fire-fighters
Use water spray, powder, alcohol-resistant foam, carbon dioxide. In case of fire: keep drums, etc., cool by spraying with water.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
6.2Environmental precautions
Remove all ignition sources. Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking liquid in sealable containers. Wash away remainder with plenty of water.
6.3Methods and materials for containment and cleaning up
Methods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.
SECTION 7: Handling and storage
7.1Precautions for safe handling
NO open flames, NO sparks and NO smoking. Above 44°C use a closed system, ventilation and explosion-proof electrical equipment. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
Fireproof. Separated from strong oxidants and food and feedstuffs. Keep in the dark. Cool.Conditions for safe storage: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
TLV: 5 ppm as TWA; (skin); BEI issued.MAK: 7.5 mg/m3, 2 ppm; peak limitation category: II(8); skin absorption (H); pregnancy risk group: B.EU-OEL: 8 mg/m3, 2 ppm as TWA; (skin)
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Wear face shield or eye protection in combination with breathing protection.
Skin protection
Protective gloves. Protective clothing.
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Liquid. |
| Colour | Colorless. |
| Odour | Sweet, pleasant, ether-like odor |
| Melting point/freezing point | -70 °C. Remarks:Pour point. |
| Boiling point or initial boiling point and boiling range | 135.6 °C. Atm. press.:1 013 hPa. Remarks:Bp. |
| Flammability | Class II Combustible Liquid: Fl.P. at or above 100°F and below 140°F. |
| Lower and upper explosion limit/flammability limit | Upper 15.6% at 93 deg C; lower 1.7% at 93 deg C |
| Flash point | 40 °C. Atm. press.:1 013.25 hPa. |
| Auto-ignition temperature | 235 °C. Atm. press.:1 013.25 hPa. Remarks:In the data source the term "autogeneous ignition temperature" was used. Atmospheric pressure of 1013.25 hPa was assumed by the author of the IUCLID data set. No info about pressure in the data source. |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | centipoise = 1.84. Temperature:25.0°C. |
| Solubility | Miscible with water |
| Partition coefficient n-octanol/water | log Pow = 0.32. Remarks:Room temperature (as described in Tanii and Hashimoto (1982)). |
| Vapour pressure | 7.51 hPa. Temperature:25 °C. |
| Density and/or relative density | 0.919. Temperature:25 °C.;0.929. Temperature:20 °C. |
| Relative vapour density | 3.1 (vs air) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
The substance can form explosive peroxides. Reacts with strong oxidants. This generates fire and explosion hazard. Attacks many plastics and rubber.
10.2Chemical stability
Stable under recommended storage conditions.
10.3Possibility of hazardous reactions
Flammable in the presence of a source of ignition when the temperature is above the flash point.ETHYLENE GLYCOL MONOMETHYL ETHER may react with oxidizing materials, i.e. hydrogen peroxide, to form peroxides. It dissolves many oils, resins and waxes. (NTP, 1992)
10.4Conditions to avoid
10.5Incompatible materials
Polyacrylamide gels were dissolved in 30% peroxide solution and added to a scintillation mixture in 1:1 2-ethoxyethanol-toluene. After counting, the mixtures were bulked and evaporated intermittently with heat during a 4 week period, and the accumulated peroxidised residues eventually exploded violently. A subsequent comment indicated that peroxidised materials may not peroxide are themselves potentially explosive.
10.6Hazardous decomposition products
Hazardous decomposition products formed under fire conditions. - Carbon oxides
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 - rat, guinea pig (male/female) - 3 000 mg/kg bw. Remarks:Rat.
- Inhalation: LC50 - rat (female) - 7.36 mg/L air.
- Dermal: LD50 - rabbit (male) - 3.56 mL/kg bw.
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
STOT-single exposure
The substance is mildly irritating to the eyes and respiratory tract. The substance may cause effects on the central nervous system, blood, bone marrow, kidneys and liver. Exposure at high levels could cause unconsciousness. Medical observation is indicated.
STOT-repeated exposure
The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the blood and bone marrow. This may result in anaemia and lesions of blood cells. May cause toxicity to human reproduction or development.
Aspiration hazard
A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20°C.
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC0 - Leuciscus idus melanotus Heckel - >= 10 000 mg/L - 48 h.
- Toxicity to daphnia and other aquatic invertebrates: EC50 - Daphnia magna - > 10 000 mg/L - 24 h.
- Toxicity to algae: NOEC - Desmodesmus subspicatus (previous name: Scenedesmus subspicatus) - >= 1 000 mg/L - 72 h.
- Toxicity to microorganisms: EC0 - other bacteria: mixed bacterial population - > 10 000 mg/L - 24 h.
12.2Persistence and degradability
AEROBIC: Ethylene glycol monoethyl ether, present at 100 mg/L, reached 76% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L in the Japanese MITI test(1). In pilot-scale activated sludge systems, ethylene glycol monoethyl ether was reduced from 2,284 mg/L in the feed to 18 mg/L in the effluent(2). No ethylene glycol monoethyl ether was detected in the off-gas or waste mixed liquor samples(2).
12.3Bioaccumulative potential
An estimated BCF value of 3 was calculated for ethylene glycol monoethyl ether(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF value suggests that bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
The Koc of ethylene glycol monoethyl ether is estimated as 2(SRC), using a log Kow of -0.32(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that ethylene glycol monoethyl ether is expected to have very high mobility in soil(SRC).
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: UN1171 (For reference only, please check.) | IMDG: UN1171 (For reference only, please check.) | IATA: UN1171 (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: ETHYLENE GLYCOL MONOETHYL ETHER (For reference only, please check.) | IMDG: ETHYLENE GLYCOL MONOETHYL ETHER (For reference only, please check.) | IATA: ETHYLENE GLYCOL MONOETHYL ETHER (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: 3 (For reference only, please check.) | IMDG: 3 (For reference only, please check.) | IATA: 3 (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: III (For reference only, please check.) | IMDG: III (For reference only, please check.) | IATA: III (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| 2-ethoxyethanol | 2-ethoxyethanol | 110-80-5 | 203-804-1 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
| Items | Specifications |
| Appearance | colorless clear liquid |
| Assay | 99 |
| Distillation range (℃ /760mmHg) | 133.5-138 |
ECHEMI Editorial Reference
colourless liquid 2-Ethoxyethanol is a colorless, viscous liquidwith a sweetish odor Ethylene glycol monoethyl ether is a colorlessliquid with a sweet, mild odor and slightly bitter taste. It is miscible in allproportions of acetone, benzene, carbon tetrachloride, ethyl ether, methanol, andwater. It dissolves many oils, resins, and waxes.ChEBI: A hydroxyether that is the ethyl ether derivative of ethylene glycol.A clear colorless liquid. Flash point of 120°F. Less dense than water.
Netherlands
Pakistan
Russia
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