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MMAE | ChemExpress

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CAS No.:

474645-27-7

Port:

shanghai

Packaging:

Price valid (until):

2024-04-26

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ChemExpress

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

CRO

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Product Description
Seller Information

Description

MMAE
Monomethyl auristatin E (MMAE; SGD-1010) is a synthetic derivative of dolastatin 10 and functions as a potent mitotic inhibitor by inhibiting tubulin polymerization. MMAE is widely used as a cytotoxic component of antibody-drug conjugates (ADCs) to treat several different cancer types.

We can provide high-quality MMAE and its derived impurities.Moreover, we provide the following technical development services:

Reliable and available kilogram-level supply;
kilogram-level GMP supply in commercial production stage;
Complete DMF registration;
CMC and regulatory affair service(IND, NDA) of Drug-Linker based on this product.

Product Specifications:purity≥99%, Total Impurities≤1.0%, KF≤1.0%

Brand：ChemExpress
CAS：474645-27-7
Catalog_No：HY-15162

Contact:
TEL：+1-970-439-2030 (USA)、+86 (21) 5895-0125 (Global)
Email：info@chemexpress.com

Brand Introduction:
ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

ChemExpress Services:

Drug Discovery: synthetic chemistry; medicine chemistry; FTE/FFS services.

Process Development: APIs and intermediates development; formulation development.

New Modalities Development: ADC; peptide; oligonucleotide and so on.

Manufactory: support production from milligrams to kilograms, both with GMP and non-GMP capabilities.

Analytical Development & Quality Control: R&D testing; stability study; genotoxic impurity research and so on.

Regulatory CMC Support

Eany development services in Synthetic Chemistny:Providing serices related to high qualty compound synthesis,chemical custom synthesis and analytical chemistry.

Pharmaceutical Chemistry eaniy development services: including high-throughput screening, drug synthesis, seding compounds, lead compounds, and IND fling support.

Process development: Covers AP! & intermediates process development, validation, transfer, and formulation development.

Commerial producion:it hasa research and development base forthe producion otapis intermediates and prenarations and provdes commeria prouction semices.

CMC services: Provide one-stop CMC services, from lND to NDA stage of pharmaceutical research and development and dedlaration services, accelerate IND declaration.

ADC drug and highly active drug development and production: Provides a one-stop CRO & CDMO service for the small molecule aspect of ADC drugs, as well as customized ADC conjugation services.

Oligonucleotide drug process development and production: Provide oligonucleotide customized products and services to meet different needs.

Analytical testing services and quality control: Provide integrated analytical testing services and drug quality research support

ChemExpress committed to being a steadfast companion for our clients, gaining profound insight into their needs. Our focus is on accelerating the empowerment of global partners across the full spectrum, from preclinical stages to commercial production. This commitment aims for more streamlined drug development, swifter market entry, and an earlier positive impact on human health.

Product details：https://www.chemexpress.com/product/HY-15162

Basic Info

Product Name:

Monomethylauristatin E

Other Name:

L-Valinamide,N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-;N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide;MMAE;Monomethylauristatin E;Monomethylauristatin norephedrine;Toxin MMAE;MMAE toxin;Monomethyl auristatin E

CAS No.:

474645-27-7

Molecular Formula:

C39H67N5O7

InChIKeys:

InChIKey=DASWEROEPLKSEI-UIJRFTGLSA-N

Molecular Weight:

717.98

Exact Mass:

717.98

UNII:

V7I58RC5EJ

NCI Thesaurus Code:

C122637

Categories:

Bulk Drug Intermediates

Characteristics

Density:

1.1±0.1 g/cm3

Boiling Point:

873.5±65.0°C at 760 mmHg

Flash Point:

482.1±34.3 °C

Refractive Index:

1.519

See More Monomethylauristatin E Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Monomethylauristatin E Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
CRO

Location:
1 Deer Park Dr, Suite Q, Monmouth Junction, NJ 08852, USA

Payment Terms:
TT against copy of documents

Average lead Time:
3

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
Above 1000

Year of Establishment:
2006

Company Profile
Founded in 2006, ChemExpress focuses on providing small molecule and new modalities CDMO services for both pharmaceutical and biotech clients. Our comprehensive CRO & CDMO platform is engaged in the research and development, manufacturing and supply of regulatory starting materials, novel building blocks, intermediates, reference compounds, APIs and drug products. We are a one-stop service platform to support our client’s projects from early drug discovery, process development to commercialization.

Over the past 17 years, we have established a state-of-the-art QC/QA system aligning with ICH guidelines for pharmaceutical manufacturing. We provide our clients with high-quality products and CMC services across the entire life-cycle of drug development.
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