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7689-03-4 Camptothecin

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Unit Price: Get Latest Price
CAS No.:

7689-03-4

Grade:

Pharmaceutical Grade

Content:

0.98%

Port:

shanghai

Brand:

Ranhang

Packaging:

According to customers demand

Price valid (until):

2024-05-28

Company Type:
Trader
Location:
China
Qualification:
Main Products:

chemical

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Camptothecin is an alkaloid extracted from the seeds or root bark of the deciduous plant Camptotheca acuminata of the Davidia family. It can directly destroy the DNA structure and DNA binding, making the DNA vulnerable to attack by endonucleases, and inhibits DNA polymerase. It affects the replication of DNA and is mainly sensitive to proliferating cells. It is a cell cycle-specific drug that acts in the S phase and has slight lethality to cells in the G1, G2 and M phases. It has an inhibitory effect on a variety of animal tumors and has no cross-resistance with commonly used anti-tumor drugs. Combined with glycyrrhizic acid monoamine salt, it can reduce toxicity without reducing therapeutic efficacy. The mechanism of topical treatment of psoriasis is to inhibit the mitosis of rapidly dividing keratinocytes, thin the proliferating spinous cell layer, disappear parakeratosis, and restore the formation of the granular layer to achieve therapeutic effect. After intravenous injection of this product, most of the drugs are bound to plasma proteins, with a half-life of 30 minutes in plasma, kidneys, and liver, with the highest content in the gastrointestinal tract, bone marrow, and kidneys. This product is excreted slowly and is mainly excreted unchanged through urine. 17% can be excreted in 48 hours. It is mainly used for gastric cancer, colon cancer, rectal cancer, head and neck cancer and bladder cancer with good curative effect.



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    Ranhang has a very strict test process to assure that goods from us are of super quality to help customers take up market in soon time!



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    Our factory is  focus on customized product development to meet different demands of customers. 

    Ranhang has our own Lab with world leading facilities, we cooperated with many famous universities and Ph.D researchers and always keep up with the market, Our researchers react quick response about modern products and offering a competitive advantage in the market.

    we highly valued the research and development,

    Especially  in customized product development. Keep on improving the  innovation capabilities to help cusotmers. 

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    Ranhang Has its own factory and warehouse, some popular products are available to be shipped ASAP.


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    If customers have no special request about the products, Usually we will use the following packaging to ship the goods. 

    DIY packaging, Let us know freely!



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    Certificates
    • 7689-03-4 Camptothecin Certificates 1

    Basic Info
    Product Name:

    (+)-Camptothecin

    Other Name:

    1,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE;(20S)-CAMPTOTHECIN;CaMpetothecin;(4S)-4-Ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;CaMptothecin(NATURAL);CaMpathecin;4-ETHYL-4-HYDROXY-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-3,14(4H,12H)DIONE;5,6-DIHYDROXY-7-GLUCURONOSYLFLAVONE

    CAS No.:

    7689-03-4

    Molecular Formula:

    C20H16N2O4

    InChIKeys:

    VSJKWCGYPAHWDS-FQEVSTJZSA-N

    Molecular Weight:

    348.35

    Exact Mass:

    348.35

    BRN:

    631069

    EC Number:

    444-280-6

    UNII:

    XT3Z54Z28A

    NSC Number:

    94600

    DSSTox ID:

    DTXSID0030956

    NCI Thesaurus Code:

    C338

    Color/Form:

    yellow

    HScode:

    29399990

    Characteristics
    PSA:

    79.7

    Physical Properties:

    Appearance: pale yellow needlelike crystal. Solubility: slightly soluble in ethanol and chloroform; poorly soluble in water; camptothecin fails to generate stable salt with acid, whereas it can produce sodium salt which is soluble in water by reacting with heated sodium hydroxide solution. Melting point: 264–267°C. Camptothecin derivatives

    XLogP3:

    1

    Appearance:

    yellow solid

    Density:

    1.3112 (rough estimate)

    Melting Point:

    260 °C (dec.)(lit.)

    Boiling Point:

    482.73°C (rough estimate)

    Flash Point:

    411.6±32.9 °C

    Refractive Index:

    1.5700 (estimate)

    Water Solubility:

    insoluble

    Storage Conditions:

    2-8°C

    Toxicity:

    Oral-rat LD50: 153 mg/kg; Oral-Mouse LD50: 50.1 mg/kg

    Flammability characteristics:

    Thermal decomposition emits toxic nitrogen oxide fumes; reacts with acids to decompose

    Specific rotation:

    D25 +31.3° (in chloroform-methanol, 8:2)

    PKA:

    pKa 10.83 (Uncertain)

    Collision Cross Section:

    181.9 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Critical Temperature & Pressure:

    2-8°C

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    Storage

    P405 Store locked up.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Trader

    Main Products:

    chemical

    Location:

    Room 237, Office Building, Shangma Yirui Industrial Park, 500 meters east of the intersection of Hedong Road and Longfei Road, Shangma Street, Chengyang District, Qingdao City, Shandong Province

    Payment Terms:

    TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    2

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    5-10

    Year of Establishment:

    2023

  • Inquiry History
    1 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    (S)-(+)-Camptothecin

    1000 KG Nov 7, 2024
    Post an enquiry for this product
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