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Home > Biochemical Engineering > Inhibitors > Ribociclib for Sale > Pharmaceutical Intermediate API Raw Material Lee011 CAS 1211441-98-3 Ribociclib Powder
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Pharmaceutical Intermediate API Raw Material Lee011 CAS 1211441-98-3 Ribociclib Powder

Unit Price: Get Latest Price
CAS No.:

1211441-98-3

Grade:

Medical grade

Content:

99%

Port:

Shanghai

Brand:

Dideu

Packaging:

1g/bottle;25kg/drum

Sample Available:

Yes

Price valid (until):

2024-05-28

Company Type:
Manufactory
Location:
China
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
7 days
Qualification:
Main Products:

Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

  • Product Description

  • Seller Information

  • Description

    High Quality Ribociclib Producer

    Shop Hexadecylpyridine hydrochloride-Detailed Image 1

    Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Ribociclib does not currently have Marketing Authorisation in the EU for any indication. Ribociclib is in phase II studies for breast cancer.

    Shop Hexadecylpyridine hydrochloride-Detailed Image 2

    Item

    Standard

    Test Results

    Appearance

    Light yellow to brown powder

    Complies

    Identification

    HPLC

    Complies

    Water,%

    ≤1.0

    0.86

    Residue on Ignition,%

    ≤0.1

    0.07

    Single impurity,%

    ≤0.3

    0.11

    Total impurity,%

    ≤1.0

    0.20

    Residual solvents,ppm

    Toluene

    ≤890

    ND

     

    Dichloromethane

    ≤600

    ND

     

    Dioxane

    ≤380

    ND

     

    Isopropanol

    ≤5000

    ND

    Assay,%

    98.0 ~ 102.0

    99.85

    Shop Hexadecylpyridine hydrochloride-Detailed Image 3

    Our normal packaging is 25kgs/Drum

    The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

    Shop Hexadecylpyridine hydrochloride-Detailed Image 4
    Shop Hexadecylpyridine hydrochloride-Detailed Image 5

    a) Free sample can be supplied.

    b) Guide our clients by professional knowledge and teach them how to use our product after sales.

    c) Accept SGS, BV any other third-party inspection before loading.

    d) High quality best price Guaranteed.

    Shop Hexadecylpyridine hydrochloride-Detailed Image 6
    Shop Hexadecylpyridine hydrochloride-Detailed Image 7

    Why do you choose Dideu as your partner?

    A) High quality can be guaranteed. Dideu since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P, D/A payment term. If there is any quality problem after goods arrive. Dideu will do fully payment refund.

    B) Best price can be guaranteed. As Dideu are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

    C) Professional engineers from Dideu will give professional usage guide and services after sales.

    D)Dideu work 7×24 hours and your request will be processed by our professional staff in different shift period.

    Shop Hexadecylpyridine hydrochloride-Detailed Image 8
    Shop Hexadecylpyridine hydrochloride-Detailed Image 9
    Shop Hexadecylpyridine hydrochloride-Detailed Image 10
    Shop Hexadecylpyridine hydrochloride-Detailed Image 11
    Shop Hexadecylpyridine hydrochloride-Detailed Image 12

    Dideu is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa. Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

     

    At the end of 2014, the company employed more than 13000 people. In 2014, Dideu Group posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China, Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

     

    Dideu Consist Of Five Industry Chains:

     

    1. 1)Pharmaceutical Industries
    2. 2)Nutrition Additive Industries
    3. 3)Daily-Use Chemical Products Industries & Agrochemicals
    4. 4)Environmental Friendly Chemical And Chemurgy Industries
    5. 5)Petrochemical Industries
    6. 6)General Chemical Industry

     

    At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility. Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

     

    At Dideu, we create chemistry for a sustainable future with science for a better life. Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials. We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms. Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.

     

    We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu. Exclusive Focus on the Life Science Businesses Following the economic and legal independence of our former Material Science subgroup. Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit. The business continues to be supported by the corporate functions, Dideu Business Services and the service company Current, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.

    ECHEMI Editorial Reference
    Ribociclib (LEE011) is a highly specific CDK4/6 inhibitor with IC50s of 10 nM and 39 nM, respectively.
    Ribociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). These proteins, when over-activated, can enable cancer cells to grow and divide too quickly. Targeting CDK4/6 with enhanced precision may play a role in ensuring that cancer cells do not continue to replicate uncontrollably. Ribociclib was approved by the U.S. FDA in March, 2017 as Kisqali.|Ribociclib is a Kinase Inhibitor. The mechanism of action of ribociclib is as a Kinase Inhibitor, and Cytochrome P450 3A Inhibitor.|Ribociclib is a unique cyclin-dependent kinase inhibitor that is used in combination with aromatase inhibitors in the treatment of postmenopausal women with metastatic breast cancer. Ribociclib is associated with a moderate rate of serum aminotransferase elevations during therapy, and to clinically apparent liver injury in a proportion of these.|Ribociclib is an orally available cyclin-dependent kinase (CDK) inhibitor targets at cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. Ribociclib specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.
    Research & Reference Note

    Pharmaceutical Intermediate API Raw Material Lee011 CAS 1211441-98-3 Ribociclib Powder is listed on ECHEMI for industrial / laboratory sourcing. This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Disclaimer: This listing is for industrial and laboratory research use. Product information on ECHEMI is provided for sourcing and specification reference. It is not medical advice, a clinical recommendation, or an approved therapy description. Always verify regulatory status, purity, and intended use with the supplier and applicable authorities before purchase or use.

    Reviewed by ECHEMI Scientific Review - Platform editorial review for research chemicals

    Basic Info
    Product Name:

    Ribociclib

    Other Name:

    7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide,7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-;7-Cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide;LEE 011;Ribociclib;LEE 011A

    CAS No.:

    1211441-98-3

    Molecular Formula:

    C23H30N8O

    InChIKeys:

    InChIKey=RHXHGRAEPCAFML-UHFFFAOYSA-N

    Molecular Weight:

    434.5373

    Exact Mass:

    434.54

    EC Number:

    1592732-453-0

    UNII:

    TK8ERE8P56

    NCI Thesaurus Code:

    C95701

    ATC Code:

    L01XE|L - Antineoplastic and immunomodulating agents

    Categories:

    Inhibitors

    Characteristics
    PSA:

    91.2

    XLogP3:

    2.2

    Density:

    1.39±0.1 g/cm3(Predicted)

    Boiling Point:

    730.8±70.0°C at 760 mmHg

    Flash Point:

    395.8±35.7 °C

    Refractive Index:

    1.723

    Hazard Identification

    Classification of the substance or mixture

    Not classified.

    GHS label elements, including precautionary statements

    Pictogram(s) No symbol.
    Signal word

    No signal word

    Hazard statement(s)

    none

    Precautionary statement(s)
    Prevention

    none

    Response

    none

    Storage

    none

    Disposal

    none

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Chemical Pesticides,Food Additives,Agrochemicals,Active Pharm Ingredients,Flavors and Fragrances,Chemical Catalyst

    Location:

    https://www.dideu.com/en/

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    7 days

    Total Annual Revenue:

    Above $100 million

    Total Employees:

    Above 1000

    Year of Establishment:

    2016

    Company Certificates
    • Shaanxi Dideu Medichem Co. LtdISO Certificate ISO Certificate
    • Shaanxi Dideu Medichem Co. LtdREACH REACH
    Company Profile
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