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Sunitinib Malate USP/EP

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CAS No.:

341031-54-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Shanghai

Packaging:

1kg/bag

Price valid (until):

2024-05-29

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Shandong Fengjin Beauty Biotech Co.,Ltd

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

HA,PGA,Recombinant collagen,EGT,Ceramides,Ectoine

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Product Description
Seller Information
Inquiry History

Description

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Shandong Fengjin Beauty Biotech is a chemical company，a multi-grade raw material supplier for medicine, food and cosmetics. We sell HA, PGA, Recombinant collagen, EGT, Ceramides, Ectoine. ect.
Dr. Zhu Xiqiang，the CEO of Fengjin Beauty Biotech is the first scientist in the world to discover that polyglutamic acid has a whitening mechanism. After several years of in-depth research on polyglutamic acid, several derivative raw materials have been developed for this ingredient. At the same time, under the leadership of Dr. Zhu Xiqiang, its R&D team has also made major breakthroughs in the fermentation and extraction process of collagen and PDRN.
You're welcome to contact with us about pharma and raw materials.

Sunitinib malate is a new type of oral multi-target anti-tumor drug. It is a multi-target tyrosine kinase inhibitor with the trade name suntent. It was successfully developed by Pfizer of the United States. , has dual anti-tumor effects and is the only therapeutic drug that can break through the 2-year survival period of advanced renal cell carcinoma. It has a core position in the treatment of renal cell carcinoma and gastrointestinal stromal tumors. It was launched in the United States in February 2006. This drug was the first An anti-cancer drug approved by the US FDA that can treat two diseases at the same time. Sunitinib works by preventing tumor cells from getting the blood and nutrients they need to grow. Clinical trials have shown that the drug can slow the growth of gastrointestinal stromal tumors and reduce the size of renal cell tumors. Sunitinib malate is the first new targeted drug that can selectively target multiple tyrosine kinase receptors, combining anti-angiogenesis by interrupting the blood supply to tumor cells and anti-tumor by directly attacking tumor cells. mechanism of action. It represents the advent of a new round of targeted therapy, which can directly attack tumors without the toxic side effects of conventional chemotherapy.

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Application

Gastrointestinal stromal carcinoma, advanced renal cell carcinoma

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Items	Specifications	Results
Characters	Yellow or orange crystalline powder	Orange crystalline powder
Identification	The product should have the maximum absorption at266nm and 426nm; the minimum absorption at 251 nm and 321 nm; The infrared absorption spectrum should be consistent with that of the reference material.	Complied
Solubility	It dissolves in dimethyl sulfoxide, slightly soluble in water.	Compied
Water content	≤0.5%	0.2%
Sulfated ash	≤0.1%	0.03%
Heavy metal	≤0.00002%	Compied
Related substances	Impurity A≤ 0.10%	0.04%
	Sunitinib nitrixide compound ≤ 0.10%	0.11%
	Impurity C≤ 0.15%	Not detected
	Other single impurity ≤ 0.10%	Max:0.03%
	Total impurities≤ 0.5%	0.26%
Assay	>98.5%（Calculate on the dried basis)	99.9%

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Certificates

Basic Info

Product Name:

Sunitinib malate

Other Name:

Butanedioic acid,2-hydroxy-,(2S)-,compd. with N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1);Butanedioic acid,hydroxy-,(2S)-,compd. with N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (1:1);1H-Pyrrole-3-carboxamide,N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-,(2S)-hydroxybutanedioate (1:1);Sunitinib malate;SU 011248;SU 11248;Sutent;Sunitinib L-malate;Sunitinib L-malate

CAS No.:

341031-54-7

Molecular Formula:

C22H27FN4O2.C4H6O5

Molecular Weight:

532.566

Exact Mass:

532.233337

EC Number:

1308068-626-2

HScode:

29337900

Categories:

Inhibitor Drugs

Characteristics

PSA:

172.06000

XLogP3:

2.77040

Density:

1.3600 g/mL at 25 °C(lit.)

Melting Point:

189-191°C

Boiling Point:

572.1ºC at 760mmHg

Flash Point:

163 °F

Refractive Index:

n20/D 1.455(lit.)

Water Solubility:

DMSO: >10mg/mL

Storage Conditions:

Store at +4°C

See More Sunitinib malate Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

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Seller Information

Business Type:
Manufactory

Main Products:
HA,PGA,Recombinant collagen,EGT,Ceramides,Ectoine

Location:
No.166 Zhongkai St., Muping District, Yantai, Shandong, China

Payment Terms:
TT against copy of documents,L/C,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
7

Total Annual Revenue:
$25 million-$50 million

Total Employees:
101-200

Year of Establishment:
2019

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Sunitinib Malate ( USP Grade )	50.00 KG	Aug 23, 2024
Russia	Sunitinib Malate	1 KG	Nov 28, 2024

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