99& White Powder (-)-Nuciferine CAS NO (475-83-2) in bulk

Comprehensive Overview of (-)-Nuciferine (475-83-2):

Introduction: (-)-Nuciferine is a natural alkaloid compound primarily found in plants of the Nelumbo genus, particularly in the seeds of the lotus plant (Nelumbo nucifera). It has been traditionally used in various cultures for its medicinal properties and is currently being investigated for its potential therapeutic applications in modern medicine.

Chemical Structure and Properties: (-)-Nuciferine has the molecular formula C19H21NO2 and belongs to the aporphine alkaloid family. Structurally, it is characterized by a tetracyclic framework containing two benzene rings fused to a central seven-membered ring and a nitrogen-containing heterocycle. (-)-Nuciferine is a white to off-white crystalline powder with a bitter taste and is sparingly soluble in water but more soluble in organic solvents such as ethanol and methanol.

Natural Sources: (-)-Nuciferine is predominantly found in the seeds and leaves of the lotus plant (Nelumbo nucifera), a sacred flower with cultural and medicinal significance in many Asian countries. It is also present in other plant species of the Nelumbonaceae family, as well as in certain species of the Nymphaeaceae family. The extraction of (-)-nuciferine from lotus seeds and other plant sources enables its utilization in various traditional remedies and modern pharmaceutical formulations.

Pharmacological Effects and Potential Health Benefits:

1. Cardiovascular Health: (-)-Nuciferine exhibits cardiovascular effects, including vasorelaxant and hypotensive properties. It helps dilate blood vessels, improve blood flow, and reduce blood pressure, making it potentially beneficial for individuals with hypertension and cardiovascular diseases.
2. Weight Management: (-)-Nuciferine has been studied for its potential role in weight management and obesity treatment. It may modulate lipid metabolism, suppress appetite, and inhibit adipogenesis, leading to reduced body weight and fat accumulation.
3. Antioxidant Activity: (-)-Nuciferine possesses antioxidant properties, scavenging free radicals and reactive oxygen species (ROS) implicated in oxidative stress-related diseases and aging processes. It helps protect cells and tissues from oxidative damage and may contribute to overall health and well-being.
4. Neuroprotective Effects: (-)-Nuciferine has shown neuroprotective effects in preclinical studies, including the protection of neurons against oxidative stress, excitotoxicity, and neuroinflammation. It may have implications for the prevention and management of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.
5. Analgesic and Anti-inflammatory Actions: (-)-Nuciferine exhibits analgesic and anti-inflammatory properties, inhibiting pain perception and inflammatory responses in animal models. It may help alleviate pain and inflammation associated with various conditions, such as arthritis, neuropathy, and inflammatory disorders.

Traditional Uses and Cultural Significance: (-)-Nuciferine has been used in traditional medicine systems, particularly in Ayurveda and Traditional Chinese Medicine (TCM), for its medicinal properties. It is employed in remedies for digestive disorders, respiratory ailments, menstrual problems, and nervous system disorders. Lotus seeds, leaves, and other plant parts containing (-)-nuciferine are used in herbal formulations, teas, tinctures, and dietary supplements for their health-promoting effects.

Safety Considerations: (-)-Nuciferine is generally regarded as safe when consumed in moderate amounts as part of traditional remedies or dietary supplements. However, high doses or prolonged use may lead to adverse effects, including gastrointestinal disturbances, dizziness, and allergic reactions. Pregnant and breastfeeding women, as well as individuals with pre-existing medical conditions or those taking medications, should consult healthcare professionals before using products containing (-)-nuciferine.

Future Research Directions: Further research is warranted to elucidate the mechanisms of action, pharmacokinetics, and therapeutic potential of (-)-nuciferine in various disease conditions. Clinical studies are needed to evaluate its efficacy, safety, and optimal dosage regimens for specific health indications. Additionally, investigations into the development of (-)-nuciferine-based pharmaceuticals and nutraceuticals may pave the way for novel treatments and interventions in healthcare.

Conclusion: (-)-Nuciferine is a natural alkaloid compound found in lotus plants, known for its pharmacological effects and potential health benefits. Its cardiovascular, weight management, antioxidant, neuroprotective, analgesic, and anti-inflammatory properties make it a subject of interest in modern medicine and traditional healing practices. Continued research efforts are essential to further explore the therapeutic potential and safety profile of (-)-nuciferine for various health conditions and applications.