SAFETY DATA SHEETS
According to the UN GHS revision 9
Version: 1.0
Creation Date: July 15, 2019
Revision Date: July 15, 2019
SECTION 1: Identification
1.1GHS Product identifier
| Product name | Methyl acetoacetate |
1.2Other means of identification
| Product number | - |
| Other names | Methyl 3-oxobutanoate; Butanoic acid, 3-oxo-, methyl ester; methyl 3-oxobutanoate |
1.3Recommended use of the chemical and restrictions on use
| Identified uses | Industrial and scientific research use. |
| Uses advised against | no data available |
SECTION 2: Hazard identification
2.1Classification of the substance or mixture
Eye irritation, Category 2
2.2GHS label elements, including precautionary statements
| Pictogram(s) |  |
| Signal word | Warning |
| Hazard statement(s) | H319 Causes serious eye irritation |
| Precautionary statement(s) |
| Prevention | P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... |
| Response | P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| Storage | none |
| Disposal | none |
2.3Other hazards which do not result in classification
SECTION 3: Composition/information on ingredients
3.1Substances
| Chemical name | Common names and synonyms | CAS number | EC number | Concentration |
| Methyl acetoacetate | Methyl acetoacetate | 105-45-3 | 203-299-8 | 100% |
SECTION 4: First-aid measures
4.1Description of necessary first-aid measures
If inhaled
Fresh air, rest. Refer for medical attention.
Following skin contact
Remove contaminated clothes. Rinse skin with plenty of water or shower.
Following eye contact
First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Following ingestion
Rinse mouth. Do NOT induce vomiting. Give one or two glasses of water to drink. Refer for medical attention .
4.2Most important symptoms/effects, acute and delayed
May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation. (USCG, 1999)
4.3Indication of immediate medical attention and special treatment needed, if necessary
Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Cover skin burns with dry sterile dressings after decontamination . Poison A and B
SECTION 5: Fire-fighting measures
5.1Suitable extinguishing media
Use/ foam, carbon dioxide, dry chemical.
5.2Specific hazards arising from the chemical
Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016)
5.3Special protective actions for fire-fighters
Use alcohol-resistant foam, powder, carbon dioxide.
SECTION 6: Accidental release measures
6.1Personal precautions, protective equipment and emergency procedures
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
6.2Environmental precautions
Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.
6.3Methods and materials for containment and cleaning up
Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.
SECTION 7: Handling and storage
7.1Precautions for safe handling
NO open flames. Above 77°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
7.2Conditions for safe storage, including any incompatibilities
SECTION 8: Exposure controls/personal protection
8.1Control parameters
Occupational Exposure limit values
Biological limit values
8.2Appropriate engineering controls
Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.
8.3Individual protection measures, such as personal protective equipment (PPE)
Eye/face protection
Skin protection
Respiratory protection
Use ventilation, local exhaust or breathing protection.
Thermal hazards
SECTION 9: Physical and chemical properties and safety characteristics
| Physical state | Methyl acetoacetate is a clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air. |
| Colour | Colorless liquid |
| Odour | Agreeable odor |
| Melting point/freezing point | -80°C |
| Boiling point or initial boiling point and boiling range | 169-170°C |
| Flammability | Combustible. |
| Lower and upper explosion limit/flammability limit | no data available |
| Flash point | 67°C |
| Auto-ignition temperature | 536° F (USCG, 1999) |
| Decomposition temperature | no data available |
| pH | no data available |
| Kinematic viscosity | 1.704 cPa at 20 deg C |
| Solubility | Soluble in 2 parts water; miscible with alcohol and ether |
| Partition coefficient n-octanol/water | log Kow = -0.69 /Estimated/ |
| Vapour pressure | 1.54mmHg at 25°C |
| Density and/or relative density | 1.077 |
| Relative vapour density | 4.0 (Air= 1) |
| Particle characteristics | no data available |
SECTION 10: Stability and reactivity
10.1Reactivity
Decomposes on burning. This produces irritating fumes. Reacts with oxidants.
10.2Chemical stability
MAA and EAA are stable liquids
10.3Possibility of hazardous reactions
FIRE HAZARD: Moderate, when exposed to heat or flame.METHYL ACETOACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides
10.4Conditions to avoid
10.5Incompatible materials
10.6Hazardous decomposition products
When heated to decomposition it emits acrid smoke and irritating fumes
SECTION 11: Toxicological information
Acute toxicity
- Oral: LD50 Rat oral 3.0 g/kg
- Inhalation: LC50 Rat inhalation >6.6 mg/L/4 hr
- Dermal: no data available
Skin corrosion/irritation
Serious eye damage/irritation
Respiratory or skin sensitization
Germ cell mutagenicity
Carcinogenicity
Reproductive toxicity
STOT-single exposure
The substance is irritating to the eyes and respiratory tract. Exposure could cause lowering of consciousness.
STOT-repeated exposure
Aspiration hazard
No indication can be given about the rate at which a harmful concentration of this substance in the air is reached on evaporation at 20°C.
SECTION 12: Ecological information
12.1Toxicity
- Toxicity to fish: LC50 Pimephales promelas (Fathead minnow) >111.4 mg/L/96 hr; static; temperature ranged from 19-20 deg C, pH ranged from 7.7 to 8.4 and dissolved oxygen ranged from 7.8 to 9.1 mg/L.
- Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; Acute immobilization test and reproduction) >236.9 mg/L/48 hr; static; exposure temperature ranged from 20-21 deg C, pH ranged from 7.9 to 8.3, and dissolved oxygen ranged from 8.7 to 8.9 mg/L
- Toxicity to algae: no data available
- Toxicity to microorganisms: no data available
12.2Persistence and degradability
AEROBIC: Methyl acetoacetate, present at 100 mg/L, reached 78% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). Methyl acetoacetate was degraded more than 90% in 2 days at 22 deg C using activated sludge inoculum in a Zahn-Wellens screening test(2).
12.3Bioaccumulative potential
An estimated BCF of 3.1 was calculated for methyl acetatoactate(SRC), using an estimated log Kow of -0.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).
12.4Mobility in soil
Using a structure estimation method based on molecular connectivity indices(1), the Koc for methyl acetoacetate can be estimated to be 1.0(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl acetoacetate is expected to have very high mobility in soil.
12.5Other adverse effects
SECTION 13: Disposal considerations
13.1Disposal methods
Product
The material can be disposed of by removal to a licensed chemical destruction plant or by controlled incineration with flue gas scrubbing. Do not contaminate water, foodstuffs, feed or seed by storage or disposal. Do not discharge to sewer systems.
Contaminated packaging
Containers can be triply rinsed (or equivalent) and offered for recycling or reconditioning. Alternatively, the packaging can be punctured to make it unusable for other purposes and then be disposed of in a sanitary landfill. Controlled incineration with flue gas scrubbing is possible for combustible packaging materials.
SECTION 14: Transport information
14.1UN Number
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.2UN Proper Shipping Name
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.3Transport hazard class(es)
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.4Packing group, if applicable
| ADR/RID: Not dangerous goods. (For reference only, please check.) | IMDG: Not dangerous goods. (For reference only, please check.) | IATA: Not dangerous goods. (For reference only, please check.) |
14.5Environmental hazards
| ADR/RID: No | IMDG: No | IATA: No |
14.6Special precautions for user
14.7Transport in bulk according to IMO instruments
SECTION 15: Regulatory information
15.1Safety, health and environmental regulations specific for the product in question
| Chemical name | Common names and synonyms | CAS number | EC number |
| Methyl acetoacetate | Methyl acetoacetate | 105-45-3 | 203-299-8 |
| European Inventory of Existing Commercial Chemical Substances (EINECS) | Listed. |
| EC Inventory | Listed. |
| United States Toxic Substances Control Act (TSCA) Inventory | Listed. |
| China Catalog of Hazardous chemicals 2015 | Not Listed. |
| New Zealand Inventory of Chemicals (NZIoC) | Listed. |
| Philippines Inventory of Chemicals and Chemical Substances (PICCS) | Listed. |
| Vietnam National Chemical Inventory | Listed. |
| Chinese Chemical Inventory of Existing Chemical Substances (China IECSC) | Listed. |
| Korea Existing Chemicals List (KECL) | Listed. |
SECTION 16: Other information
Information on revision
| Creation Date | July 15, 2019 |
| Revision Date | July 15, 2019 |
Abbreviations and acronyms
- CAS: Chemical Abstracts Service
- ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
- RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
- IMDG: International Maritime Dangerous Goods
- IATA: International Air Transportation Association
- TWA: Time Weighted Average
- STEL: Short term exposure limit
- LC50: Lethal Concentration 50%
- LD50: Lethal Dose 50%
- EC50: Effective Concentration 50%
ECHEMI Editorial Reference
Colorless, clear liquidA clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.
Methyl acetoacetate appears as a clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.|Liquid|COLOURLESS LIQUID WITH CHARACTERISTIC ODOUR.
Methyl acetoacetate appears as a clear colorless liquid. Flash point 158°F. Denser than water and slightly soluble in water. Vapors heavier than air.|Methylacetoacetic acid is an oxo carboxylic acid.
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