Eye irritation, Category 2

no data available

If inhaled

Following skin contact

Following eye contact

Following ingestion

May be harmful by inhalation, ingestion, or skin absorption. Causes eye irritation. May cause skin irritation. (USCG, 1999)

Basic treatment: Establish a patent airway. Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary . Monitor for shock and treat if necessary . Anticipate seizures and treat if necessary . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with normal saline during transport . Do not use emetics. For ingestion, rinse mouth and administer 5 ml/kg up to 200 ml of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool . Cover skin burns with dry sterile dressings after decontamination . Poison A and B

Use/ foam, carbon dioxide, dry chemical.

Excerpt from ERG Guide 128 [Flammable Liquids (Water-Immiscible)]: HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. Substance may be transported hot. For hybrid vehicles, ERG Guide 147 (lithium ion batteries) or ERG Guide 138 (sodium batteries) should also be consulted. If molten aluminum is involved, refer to ERG Guide 169. (ERG, 2016)

Use alcohol-resistant foam, powder, carbon dioxide.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Personal protection: filter respirator for organic gases and vapours adapted to the airborne concentration of the substance. Ventilation. Collect leaking and spilled liquid in sealable containers as far as possible. Wash away remainder with plenty of water.

Collect and arrange disposal. Keep the chemical in suitable and closed containers for disposal. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Adhered or collected material should be promptly disposed of, in accordance with appropriate laws and regulations.

NO open flames. Above 77°C use a closed system and ventilation. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Separated from oxidants.

Occupational Exposure limit values

Biological limit values

Ensure adequate ventilation. Handle in accordance with good industrial hygiene and safety practice. Set up emergency exits and the risk-elimination area.

Eye/face protection

Skin protection

Respiratory protection

Thermal hazards

Decomposes on burning. This produces irritating fumes. Reacts with oxidants.

MAA and EAA are stable liquids

FIRE HAZARD: Moderate, when exposed to heat or flame.METHYL ACETOACETATE is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides

no data available

no data available

When heated to decomposition it emits acrid smoke and irritating fumes

Acute toxicity

• Oral: LD50 Rat oral 3.0 g/kg
• Inhalation: LC50 Rat inhalation >6.6 mg/L/4 hr
• Dermal: no data available

Skin corrosion/irritation

Serious eye damage/irritation

Respiratory or skin sensitization

Germ cell mutagenicity

Carcinogenicity

Reproductive toxicity

STOT-single exposure

STOT-repeated exposure

Aspiration hazard

• Toxicity to fish: LC50 Pimephales promelas (Fathead minnow) >111.4 mg/L/96 hr; static; temperature ranged from 19-20 deg C, pH ranged from 7.7 to 8.4 and dissolved oxygen ranged from 7.8 to 9.1 mg/L.
• Toxicity to daphnia and other aquatic invertebrates: EC50 Daphnia magna (Water flea; Acute immobilization test and reproduction) >236.9 mg/L/48 hr; static; exposure temperature ranged from 20-21 deg C, pH ranged from 7.9 to 8.3, and dissolved oxygen ranged from 8.7 to 8.9 mg/L
• Toxicity to algae: no data available
• Toxicity to microorganisms: no data available

AEROBIC: Methyl acetoacetate, present at 100 mg/L, reached 78% of its theoretical BOD in 2 weeks using an activated sludge inoculum at 30 mg/L and the Japanese MITI test(1). Methyl acetoacetate was degraded more than 90% in 2 days at 22 deg C using activated sludge inoculum in a Zahn-Wellens screening test(2).

An estimated BCF of 3.1 was calculated for methyl acetatoactate(SRC), using an estimated log Kow of -0.69(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for methyl acetoacetate can be estimated to be 1.0(SRC). According to a classification scheme(2), this estimated Koc value suggests that methyl acetoacetate is expected to have very high mobility in soil.

no data available

Product

Contaminated packaging

no data available

no data available

Information on revision

Abbreviations and acronyms

• CAS: Chemical Abstracts Service
• ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
• RID: Regulation concerning the International Carriage of Dangerous Goods by Rail
• IMDG: International Maritime Dangerous Goods
• IATA: International Air Transportation Association
• TWA: Time Weighted Average
• STEL: Short term exposure limit
• LC50: Lethal Concentration 50%
• LD50: Lethal Dose 50%
• EC50: Effective Concentration 50%