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Home > Active Pharmaceutical Ingredients > Other Chemical Drugs > Pyrimethamine for Sale > Antizoan Veterinary Drug CAS58-14-0 Pyrimethamine Powder
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Antizoan Veterinary Drug CAS58-14-0 Pyrimethamine Powder

Unit Price:

$100-120/KG FOB

Get Latest Price
CAS No.:

58-14-0

Grade:

Pharmaceutical Grade

Content:

99%

Port:

china any port

Brand:

TNJONE

Packaging:

1kg,25kgor according to customer's detail requirement.

Price valid (until):

2028-12-30

Company Type:
Manufactory
Location:
China
Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
Average Lead Time:
5 days
Qualification:
Main Products:

Semaglutide,Tirzepatide,API,Vitamins,Food Additive

  • Product Description

  • Seller Information

  • Description

    Antizoan Veterinary Drug CAS58-14-0 Pyrimethamine Powder

    What is Pyrimethamine?

    Pyrimethamine, also known as immortal, darapirin, is a broad-spectrum veterinary drug widely used for antiprotozoal. In addition, pyrimethamine is also used in aquatic products to enhance the disease resistance of aquatic fish. However, the side effects of pyrimethamine are relatively large. Excessive use can damage the reproductive system of livestock and poultry and is not easy to recover. Pyrimethamine has an inhibitory effect on the primary infrared stage of certain falciparum malaria and vivax malaria, and is a better preventive medicine. Although it has no obvious effect on the gametophytes of malaria parasites, the drug-containing blood enters the mosquitoes, which can affect the development of the gametophytes in the mosquitoes, so it can block transmission.


    Pyrimethamine  is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.


    This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. Pyrimethamine is used with other medication (such as a sulfonamide) to treat a serious parasite infection (toxoplasmosis) of the body, brain, or eye or to prevent toxoplasmosis infection in people with HIV infection.

    Items Specifications
    Product Name Pyrimethamine
    Cas No 58-14-0
    Einecs 200-364-2
    MF C12H13ClN4
    MW 248.71
    Melting Point 233-234°C
    Boiling Point 393.35°C (rough estimate)
    Density 1.2171 (rough estimate)
    Appearance White powder
    Shelf Life 2 Years When Properly Stored
    Storage Keep in a cool, dry, dark location in a tightly sealed container or cylinder.


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    Certification

    tems

    Standards

    Results

    Physical Analysis

       

    Description

    White Powder Complies

    Assay

    99% 99.6%

    Mesh Size

    100 % pass 80 mesh Complies

    Ash

    ≤ 5.0% 2.85%

    Loss on Drying

    ≤ 5.0% 2.65%

    Chemical Analysis

       

    Heavy Metal

    ≤ 10.0 mg/kg

    Complies

    Pb

    ≤ 2.0 mg/kg

    Complies

    As

    ≤ 1.0 mg/kg Complies

    Hg

    ≤ 0.1mg/kg Complies

    Microbiological Analysis

       

    Residue of Pesticide

    Negative Negative

    Total Plate Count

    ≤ 1000cfu/g Complies

    Yeast&Mold

    ≤ 100cfu/g Complies

    E.coil

    Negative

    Negative

    Salmonella

    Negative

    Negative


    Function  

    Pyrimethamine (RP4753) can interfere with the synthesis of tetrahydrofolate by inhibiting dihydrofolate reductase (DHFR), which can act on protozoan infections.
    This product can inhibit the dihydrofolate reductase of the plasmodium, thereby interfering with the normal generation of folic acid of the plasmodium. It is effective in the early stage of falciparum malaria and Plasmodium vivax erythrocytes. It is often used as a pathogenic preventive drug. In addition, it can also inhibit the development of malaria parasites in mosquitoes, so it can block transmission. It is clinically used to prevent malaria and anti-relapse treatment during resting period.


    Application

    1. Because of its unique characteristics, Pyrimethamine can inhibit dihydrofolate reductase of Plasmodium, the parasite and thus interfere with the normal generation of radio folic acid, for Plasmodium falciparum and P. vivax erythrocyte pre-effective and commonly used for the cause of preventive medicine. In addition, it can inhibit the development of malaria parasites in mosquitoes, it can interrupt transmission. For the prevention of malaria and telogen anti-retroviral therapy clinic.
    2. Used for pesticides and reagents for analysis.
    Used as strong basic catalyst, ethoxylating agent and as reductant for organic synthesis, pharmaceutical synthesis, etc.
    3. Used in medicine industry, such as phenylbutazone, methyldopa, hydrochloride, aminopterin, pyrimethamine, pifu ampicillin and so on.

    Company Information 


    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital of Xi 'an, is committed to pharmaceutical raw materials, kill varieties, food and feed additives, chemical reagents, plant extracts and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products. Our company after careful planning, hard study, gradually formed a complete service system, based on the domestic and foreign raw materials market special development. Make the raw materials industry bigger and stronger, and serve the vast number of new and old customers. With "world peace and health" as its responsibility, the company adheres to the service concept of "meeting all requirements of customers for products", and guarantees the service principle of "providing qualified products", so that you can get the "God-like" noble shopping enjoyment. Our company has more than 500 kinds of raw materials inventory at any time to meet the various needs of customers for products. The company's products all comply with the relevant national regulations, from the smallest packaging to tons of goods are available. Is your choice of raw materials the best partner.


    Shaanxi TNJONE Pharmaceutical Technology Co., Ltd. is willing to rely on the rapid development of e-commerce and national policy support of the good environment background, nesting, welcome people from all walks of life to visit our company, exchange, and seek common development, looking forward to sharing with you, win-win, to realize the dream.


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    FAQ

    1.How to get in touch with us?

    You can chat with us by Trademanager,WhatsApp or simply giving us an email, a phone call. All our contacts information can be found from our website.

     

    2.Are you a manufacturer or trade company?

    We are a professional manufacturer.

     

    3.Can I get a sample?

    Yes, free sample can be provided, but shipping cost is covered by your side.

     

    4.What's your MOQ?

    It is based on the different product. Some are 1g while some are 1 kg. Please be free to consult our salesman.

     

    5.When can I get the quotation?
    We usually quote within 1 hours after we get your inquiry. If it's a urgent order you can call us or mention it in your email subject, and we can take it as priority.

     

    6.Is there any discount?
    Yes, some products are applied for discount, but it depends on the quantity.

     

    7.Can you do OEM for me?
    Yes,we accept OEM orders, just contact us and give us your requirement. We will offer you a reasonable price and make samples ASAP.

    ECHEMI Editorial Reference
    Pyrimethamine(RP4753) is a medication used for protozoal infections; interferes with tetrahydrofolic acid synthesis from folic acid by inhibiting the enzyme dihydrofolate reductase (DHFR).IC50 Value: 15.4 nM (Plasmodium falciparum) [1]Target: DHFR; antifolatein vitro: Three susceptibility levels (susceptible, intermediate, and resistant) were observed in the response of culture-adapted clones and strains to pyrimethamine (50% inhibitory concentration [IC50]) < 100, 100-2,000, and > 2,000
    Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Solid
    Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.|Pyrimethamine is an aminopyrimidine that is pyrimidine-2,4-diamine which is substituted at position 5 by a p-chlorophenyl group and at position 6 by an ethyl group. It is a folic acid antagonist used as an antimalarial or with a sulfonamide to treat toxoplasmosis. It has a role as an antimalarial, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an antiprotozoal drug. It is an aminopyrimidine and a member of monochlorobenzenes.|One of the folic acid antagonists that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.|Pyrimethamine is a Dihydrofolate Reductase Inhibitor Antimalarial. The mechanism of action of pyrimethamine is as a Dihydrofolate Reductase Inhibitor.|Pyrimethamine is a synthetic derivative of ethyl-pyrimidine with potent antimalarial properties. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)|One of the FOLIC ACID ANTAGONISTS that is used as an antimalarial or with a sulfonamide to treat toxoplasmosis.

    Basic Info
    Product Name:

    Pyrimethamine

    Other Name:

    2,4-Pyrimidinediamine,5-(4-chlorophenyl)-6-ethyl-;Pyrimidine,2,4-diamino-5-(p-chlorophenyl)-6-ethyl-;5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine;4753 R.P.;BW 50-63;Chloridin;Chloridine;Darapram;Daraprim;2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine;Malocide;Pyrimethamine;Daraprime;5-(4-Chlorophenyl)-2,4-diamino-6-ethylpyrimidine;2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine;5-(P-Chlorophenyl)-6-ethyl-2,4-diaminopyrimidine;Darachlor;Malocid;Pirimetamin;Tindurin;Khloridin;Malacid;Pyrimethamin;Pirimecidan;Diaminopyritamin;Erbaprelina;NSC 3061;WR 2978;RP 4753;Tinduring

    CAS No.:

    58-14-0

    Molecular Formula:

    C12H13ClN4

    InChIKeys:

    InChIKey=WKSAUQYGYAYLPV-UHFFFAOYSA-N

    Molecular Weight:

    248.71

    Exact Mass:

    248.71

    EC Number:

    200-364-2

    UNII:

    Z3614QOX8W

    NSC Number:

    757306|3061

    UN Number:

    2811

    DSSTox ID:

    DTXSID9021217

    NCI Thesaurus Code:

    C788

    Color/Form:

    Crystals|White scored tablets contains 25 mg pyrimethamine /Daraprim/

    ATC Code:

    P01BD01|P - Antiparasitic products, insecticides and repellents

    HScode:

    2933599090

    Categories:

    Other Chemical Drugs

    Characteristics
    PSA:

    77.8

    XLogP3:

    2.7

    Appearance:

    Pyrimethamine is an odorless white crystalline powder. Tasteless. An antimalarial drug.

    Density:

    1.4±0.1 g/cm3

    Melting Point:

    233.5 °C

    Boiling Point:

    491.5°C at 760 mmHg

    Flash Point:

    176.6±30.7 °C

    Refractive Index:

    1.667

    Water Solubility:

    H2O: <0.01 g/100 mL at 21 ºC

    Storage Conditions:

    0-6°C

    Vapor Pressure:

    1.32X10-8 mm Hg at 25 deg C (est)

    Toxicity:

    LD50 oral in rat: 440mg/kg

    PKA:

    7.34(at 20 °C)

    Henrys Law Constant:

    Henry's Law constant = 1.08X10-10 atm-cu m/mol at 25 °C (est)

    Dissociation Constants:

    7.34 (at 20 °C)|pKa = 7.34 at 20 °C (conjugate acid)

    Collision Cross Section:

    155.8 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Hydroxyl radical reaction rate constant = 2.0X10-10 cu cm/molecule-sec at 25 °C (est)

    Air and Water Reactions:

    Insoluble in water.

    Reactive Group:

    Amines, Phosphines, and Pyridines

    Reactivity Profile:

    PYRIMETHAMINE is sensitive to exposure to light (NTP, 1992). Neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 4, Oral

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Warning

    Hazard statement(s)

    H302 Harmful if swallowed

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    Response

    P301+P317 IF SWALLOWED: Get medical help.

    P330 Rinse mouth.

    Storage

    none

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Store at 15 deg to 25 deg C (59 deg to 77 deg F) in a dry place and protect from light.

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Semaglutide,Tirzepatide,API,Vitamins,Food Additive

    Location:

    No. 4C-11-A392, Financial Port, Northwest corner of Fengjing Avenue and Fengxin Road, Fengdong New City, Xi 'an, Shaanxi Province

    Payment Terms:

    TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

    Average lead Time:

    5 days

    Total Annual Revenue:

    $5 million-$10 million

    Total Employees:

    11-50

    Year of Establishment:

    2019

    Shaanxi TNJONE Pharmaceutical Technology Co., LTD., located in the beautiful ancient capital Xi 'an, is committed to the peptide industry, pharmaceutical raw materials, food and feed additives, veterinary drugs and other fields, the enterprise adhering to provide customers with quality service, supply high-quality products, "world peace and health" as its responsibility, the company adhering to the "meet all customer requirements for products" as the service concept, Guarantee "provide qualified products" as the service principle, so that you get "God-like" noble shopping enjoyment. Our company has more than 1000 kinds of polypeptides, raw materials inventory, at any time to meet the various needs of customers for products. Is your best partner.
  • Country Product Purchase Quantity Date Posted
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