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Super High Quality Intermediates Candesartan CAS: 139481-59-7

Name: Super High Quality Intermediates Candesartan CAS: 139481-59-7
Brand: Airuike
SKU: pr2407012357
Price: 1 USD
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CAS No.:

139481-59-7

Grade:

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Product Name	Grade / Content	Supplier Name	Details
Candesartan	/	Hangzhou Dawn Ray Pharmaceutical Co.,Ltd	Inquiry
High Quality Intermediates Candesartan CAS: 139481-59-7	/0.00	SHANDONG LOOK CHEMICAL CO.,LTD	Inquiry
Cost-effective sourcing of 99% pure Candesartan CAS 139481-59-7 raw material	Pharmaceutical Grade/99	Xi'an Honest BioEngr Co.,Ltd.	Inquiry
Candesartan	/99.00	HANGZHOU LEAP CHEM CO., LTD.	Inquiry
Candesartan 99%	/98	Conier Chem&Pharma Limited	Inquiry

Product Description
Seller Information
Inquiry History

Description

Product Detail

Product description:Candesartan, a prodrug of candesartan cilexetil, is a new type of rapid development after angiotensin-converting enzyme inhibitor (ACEI) that acts on the renin-angiotensin system (RAS) medicine.

Melting point	183-185°C
Boiling point	754.8±70.0 °C(Predicted)
density	1.41±0.1 g/cm3(Predicted)
RTECS	DD6671000
storage temp.	Inert atmosphere,Store in freezer, under -20°C
pka	2.06±0.10(Predicted)
Water Solubility	Soluble water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
CAS DataBase Reference	139481-59-7(CAS DataBase Reference)

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ECHEMI Editorial Reference

Crystalline SolidChEBI: A benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin eceptor antagonist used for the treatment of hypertension.Candesartan, (+)-1-[[(cyclohexyloxy)carbonyl]-oxy]ethyl 2- ethoxy-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate(Atacand), like losartan, possesses the acidic
Solid
Candesartan is a benzimidazolecarboxylic acid that is 1H-benzimidazole-7-carboxylic acid substituted by an ethoxy group at position 2 and a ({2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl}methyl) group at position 1. It is a angiotensin receptor antagonist used for the treatment of hypertension. It has a role as an antihypertensive agent, an angiotensin receptor antagonist, an environmental contaminant and a xenobiotic. It is a benzimidazolecarboxylic acid and a biphenylyltetrazole. It is a conjugate acid of a candesartan(2-).|Candesartan is an angiotensin-receptor blocker (ARB) that may be used alone or with other agents to treat hypertension. It is available as a prodrug in the form of [candesartan cilexetil].|Candesartan is an Angiotensin 2 Receptor Blocker. The mechanism of action of candesartan is as an Angiotensin 2 Receptor Antagonist.|Candesartan is an angiotensin II receptor blocker used widely in the therapy of hypertension and heart failure. Candesartan is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.|Candesartan is a synthetic, benzimidazole-derived angiotensin II receptor antagonist prodrug with antihypertensive activity. Candesartan selectively competes with angiotensin II for the binding of the angiotensin II receptor subtype 1 (AT1) in vascular smooth muscle, blocking angiotensin II-mediated vasoconstriction and inducing vasodilatation. In addition, antagonism of AT1 in the adrenal gland inhibits angiotensin II-stimulated aldosterone synthesis and secretion by the adrenal cortex; sodium and water excretion increase, followed by a reduction in plasma volume and blood pressure.

Basic Info

Product Name:

Candesartan

Other Name:

1H-Benzimidazole-7-carboxylic acid,2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;1H-Benzimidazole-7-carboxylic acid,2-ethoxy-1-[[2′-(1H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-;2-Ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid;CV 11974;Candesartan;Candesartan M1;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)-1,1′-biphenyl-4-yl]methyl]-7-benzimidazolecarboxylic acid;2-Ethoxy-1-[[2′-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid;3-[[2′-(1H-Tetrazol-5-yl)biphenyl-4-yl]methyl]-2-ethoxy-3H-benzimidazole-4-carboxylic acid;1-((2′-(1H-Tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylic acid;2-Ethoxy-1-([4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl)-1H-1,3-benzodiazole-7-carboxylic acid;875515-04-1

CAS No.:

139481-59-7

Molecular Formula:

C24H20N6O3

InChIKeys:

InChIKey=HTQMVQVXFRQIKW-UHFFFAOYSA-N

Molecular Weight:

440.45

Exact Mass:

440.45

EC Number:

1806241-263-5

UNII:

S8Q36MD2XX

NSC Number:

759858

DSSTox ID:

DTXSID0022725

NCI Thesaurus Code:

C65284

Color/Form:

Colorless crystals from ethyl acetate + methanol

ATC Code:

C - Cardiovascular system

HScode:

29419000

Categories:

Circulatory System Drugs

Characteristics

PSA:

119

XLogP3:

4.1

Appearance:

Solid

Density:

1.41±0.1 g/cm3(Predicted)

Melting Point:

183-185 °C

Boiling Point:

754.8±70.0 °C(Predicted)

Flash Point:

410.3±35.7 °C

Refractive Index:

1.719

Water Solubility:

soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.8X10-18 mm Hg at 25 deg C (est)

Henrys Law Constant:

Henry's Law constant = 8.7X10-19 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 2.45 (carboxylic acid); pKa2 = 6.70 (N-heterocyclic) (est)

Experimental Properties:

Colorless crystals from ethanol + water, mp 163 °C (decomposes). Also reported as white to off-white powder, sparingly soluble in methanol. Practically insoluble in water. /Candesartan 1-[[(Cyclohexyloxy)carbonyl]oxy]ethyl ester/|White to off-white powder, mw - 610.67. Practically insoluble in water and sparingly soluble in methanol. ... a racemic mixture containing one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration ... undergoes hydrolysis at the ester link to form the active drug, candesartan, which is achiral. /Cilexetil/|White, or practically white, crystalline powder, mw - 297.72 .. Slightly soluble in water, but freely soluble in hydroxide solution /Cilexetil hydrochlorothiazide/|Hydroxyl radical reaction rate constant = 4.96X10-11 cu cm/molec-sec at 25 °C (est)

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Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Candesartan Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals

Location:
Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10 Beijing Road, Jiaonan City)

Payment Terms:
TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2023

Company Certificates
- Credit rating certificate
- Hazardous Chemicals Business License
Company Profile
Foucsing on chemical industry,Shandong Airuike Chemical Co., LTD was established in the year 2013 and since then devoted all its efforts on how to bring best products and services to every customer,with intergrated sources and creative minds.
We are offering the market with Organic chemicals, Inorganic chemicals, Organic intermediates and water treatment products.
In construction industry,our furan resin product is high-light for metal casting as well as anticorrosion projecting for new chemical plant construction and repairing works.
Your consistent trust is our infinite power to move forward. Shandong Airuike Chemical Co., LTD never stop its step on technical researching,quality supervising,effective logistic arranging and on time services to fully satisfy customers requests. We also extended our product range by close cooperating with famous producers all around China,around the world.
By now we have established business relationship with more than 200 customers around the world.
Like our company motto says,”Innovation as power,quality as life,be honest people practical development”,Shandong Airuike Chemical Co., LTD team always put sincerity and honesty in the first place and in return customers trust us and develop win-win cooperation betwwen each other.
You’re always welcomed to contact us and share your needs,let us give you an unique satisfying for our business cooperation together.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Candesartan	2000 KG	May 26, 2025

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Super High Quality Intermediates Candesartan CAS: 139481-59-7

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