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Entrectinib CAS 1108743-60-7

Name: Entrectinib CAS 1108743-60-7
Brand: airuike
SKU: pr2407081580
Price: 100 USD
Availability: InStock

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CAS No.:

1108743-60-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

airuike

Packaging:

25kg/Cardboard Drum

Price valid (until):

2025-07-20

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Shandong Airuike Chemical Co., Ltd.

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

15 days

Qualification:

Main Products:

api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals

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Product Description
Seller Information
Inquiry History

Description

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FAQ

Q : What is your terms of payment?
A : T/T 30% as deposit, and 70% before delivery or 100% L/C at sight.
Q : How to confirm the Product Quality before placing orders?
A : You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q : How about the delivery time?
A : Within 7 days after payment confirmation. (excluding Chinese holidays)

Q : What documents did you provide?
A :We usually provide commercial invoice, packing list, shipping list, waybill, health certificate and certificate of origin. If
there are any special requirements in your market, please let us know.Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Q: How do you deal with quality complaints?
A : First of all, our quality control will ensure our quality. If we cause real quality problems, we will once again provide good
products or refund your losses.

Q : How do you make our business long-term and good relationship?
A : 1. We keep good quality and competitive price to ensure our customers benefit;
2. We respect every customer as our friend and we sincerely do business and make friends with them, no matter where they come from

Q : Do you have stock?
A: Yes, we have all our products in stock. Our annual output is 200 tons. No matter when you order, we will ship within 1 to 3 days.
Q : Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over
5years, in average.Strict quality control-comes form our sophisticated management system.Professional and warm sales team-since we
believe we can only win via our hard work in a competitive worldQuick response and excellent presale and after sale service-since
we believe our customers deserve all the best service.
Q : Can I get best price from you?
A: Of course. We don't chase excessive profits and alway

ECHEMI Editorial Reference

Entrectinib is a potent and orally available Trk, ROS1, and ALK inhibitor; inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively.
Entrectinib is a tropomyosin receptor tyrosine kinase (TRK) TRKA, TRKB, TRKC, proto-oncogene tyrosine-protein kinase ROS1, and anaplastic lymphoma kinase (ALK) inhibitor. It was approved by the FDA in August 2019 for use in the treatment of ROS1-positive metastatic non-small cell lung cancer and NTRK gene fusion positive solid tumors. Entrectinib's approved use is meant as a last line of therapy due to its accelerated approval based on early trial data. This therapy offers benefit over similar ALK inhibitors such as [alectinib], [ceritinib], and [lorlatinib] due to a wider range of targets.|Entrectinib is an oral selective inhibitor of the neurotrophic T receptor kinase (NTRK) and ROS1 that is used to treat solid tumors with NTRK gene fusion and non-small cell lung cancer with ROS1 mutations. Serum aminotransferase elevations are common during therapy but clinically apparent liver injury is rare, although it has been reported.|Entrectinib is an orally bioavailable inhibitor of the tyrosine kinases tropomyosin receptor kinases (Trk) A, B and C, C-ros oncogene 1 (ROS1) and anaplastic lymphoma kinase (ALK), with potential antineoplastic activity. Upon administration, entrectinib binds to and inhibits TrkA, TrkB, TrkC, ROS1 and ALK. Inhibition of these kinases may result in a disruption of TrkA-, TrkB-, TrkC-, ROS1-, and ALK-mediated signaling. This leads to an induction of apoptosis and an inhibition of tumor cell proliferation in tumor cells that express these kinases. TrkA, TrkB, TrkC, ROS1 and ALK are overexpressed in a variety of cancer cell types.

Basic Info

Product Name:

Entrectinib

Other Name:

Benzamide,N-[5-[(3,5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]-;N-[5-[(3,5-Difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]benzamide;Entrectinib;RXDX 101;NMS-E 628;Rozlytrek;NMS-E628;RXDX-101;RG 6268;RG6268;RG-6268

CAS No.:

1108743-60-7

Molecular Formula:

C31H34F2N6O2

InChIKeys:

InChIKey=HAYYBYPASCDWEQ-UHFFFAOYSA-N

Molecular Weight:

560.6

Exact Mass:

560.64

UNII:

L5ORF0AN1I

NCI Thesaurus Code:

C114984

ATC Code:

L01EX14|L - Antineoplastic and immunomodulating agents

Categories:

Other Chemical Drugs

Characteristics

PSA:

85.5

XLogP3:

5.7

Density:

1.340±0.06 g/cm3(Predicted)

Boiling Point:

717.5±60.0 °C(Predicted)

Flash Point:

387.7±32.9 °C

Refractive Index:

1.672

See More Entrectinib Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Entrectinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals

Location:
Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10 Beijing Road, Jiaonan City)

Payment Terms:
TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2023

Company Certificates
- Credit rating certificate
- Hazardous Chemicals Business License
Company Profile
Foucsing on chemical industry,Shandong Airuike Chemical Co., LTD was established in the year 2013 and since then devoted all its efforts on how to bring best products and services to every customer,with intergrated sources and creative minds.
We are offering the market with Organic chemicals, Inorganic chemicals, Organic intermediates and water treatment products.
In construction industry,our furan resin product is high-light for metal casting as well as anticorrosion projecting for new chemical plant construction and repairing works.
Your consistent trust is our infinite power to move forward. Shandong Airuike Chemical Co., LTD never stop its step on technical researching,quality supervising,effective logistic arranging and on time services to fully satisfy customers requests. We also extended our product range by close cooperating with famous producers all around China,around the world.
By now we have established business relationship with more than 200 customers around the world.
Like our company motto says,”Innovation as power,quality as life,be honest people practical development”,Shandong Airuike Chemical Co., LTD team always put sincerity and honesty in the first place and in return customers trust us and develop win-win cooperation betwwen each other.
You’re always welcomed to contact us and share your needs,let us give you an unique satisfying for our business cooperation together.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Entrectinib	1 KG	Dec 18, 2025

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Entrectinib CAS 1108743-60-7

Product Description

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