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Airuike Dacomitinib cas 1110813-31-4

Name: Airuike Dacomitinib cas 1110813-31-4
Brand: AIRUIKE
SKU: pr2407081779
Price: 50 USD
Availability: InStock

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CAS No.:

1110813-31-4

Grade:

Analytical Reagent

Content:

99%

Port:

qingdao

Brand:

AIRUIKE

Packaging:

1kg

Price valid (until):

2024-09-17

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Shandong Airuike Chemical Co., Ltd.

Company Type:

Trader

Location:

China

Qualification:

Main Products:

api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals

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Product Description
Seller Information
Inquiry History

Description

Shop Airuike Dacomitinib cas 1110813-31-4-Detailed Image 1

FAQ

Q : What is your terms of payment?

A : T/T 30% as deposit, and 70% before delivery or 100% L/C at sight.
Q : How to confirm the Product Quality before placing orders?
A : You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q : How about the delivery time?
A : Within 7 days after payment confirmation. (excluding Chinese holidays)

Q : What documents did you provide?
A :We usually provide commercial invoice, packing list, shipping list, waybill, health certificate and certificate of origin. If
there are any special requirements in your market, please let us know.Some technical paperwork is available, such as COA, HNMR, HPLC, LC-MS etc.

Q: How do you deal with quality complaints?
A : First of all, our quality control will ensure our quality. If we cause real quality problems, we will once again provide good
products or refund your losses.

Q : How do you make our business long-term and good relationship?
A : 1. We keep good quality and competitive price to ensure our customers benefit;
2. We respect every customer as our friend and we sincerely do business and make friends with them, no matter where they come from

Q : Do you have stock?
A: Yes, we have all our products in stock. Our annual output is 200 tons. No matter when you order, we will ship within 1 to 3 days.
Q : Why should I choose you?
A: Powerful technical support-come from our highly skilled & fully experienced staff, working in chemical industry for over
5years, in average.Strict quality control-comes form our sophisticated management system

.Professional and warm sales team-since we
believe we can only win via our hard work in a competitive worldQuick response and excellent presale and after sale service-since
we believe our customers deserve all the best service.
Q : Can I get best price from you?
A: Of course. We don't chase excessive profits and alway

ECHEMI Editorial Reference

Dacomitinib is a specific and irreversible inhibitor of the ERBB family of kinases with IC50s of 6 nM, 45.7 nM and 73.7 nM for EGFR, ERBB2, and ERBB4, respectively.
Dacomitinib is a member of the class of quinazolines that is 7-methoxyquinazoline-4,6-diamine in which the amino group at position 4 is substituted by a 3-chloro-4-fluorophenyl group and the amino group at position 6 is substituted by an (E)-4-(piperidin-1-yl)but-2-enoyl group. It has a role as an epidermal growth factor receptor antagonist and an antineoplastic agent. It is a member of quinazolines, a member of piperidines, an enamide, a member of monochlorobenzenes, a member of monofluorobenzenes, a tertiary amino compound, a secondary amino compound and a secondary carboxamide.|Dacomitinib, designed as (2E)-N-16-4-(piperidin-1-yl) but-2-enamide, is an oral highly selective quinazalone part of the second-generation tyrosine kinase inhibitors which are characterized by the irreversible binding at the ATP domain of the epidermal growth factor receptor family kinase domains. Dacomitinib was developed by Pfizer Inc and approved by the FDA on September 27, 2018. Some evidence in the literature suggests the therapeutic potential of dacomitinib in the epithelial ovarian cancer model, although further investigations are needed.|Dacomitinib is a multi-kinase receptor inhibitor used in the therapy of cases of non-small cell lung cancer that harbor activating mutations in the epidermal growth factor receptor gene (EGFR). Dacomitinib is associated with high rate of transient serum aminotransferase elevations during therapy but has not been linked to instances of clinically apparent acute liver injury.

Basic Info

Product Name:

Dacomitinib

Other Name:

2-Butenamide,N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-,(2E)-;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide;Dacomitinib;PF 00299804;PF 299804;PF 299;1006885-28-4

CAS No.:

1110813-31-4

Molecular Formula:

C24H25ClFN5O2

InChIKeys:

InChIKey=LVXJQMNHJWSHET-AATRIKPKSA-N

Molecular Weight:

469.9390032

Exact Mass:

469.94

EC Number:

-0

UNII:

2XJX250C20

DSSTox ID:

DTXSID50149493

ATC Code:

L01EB07|L - Antineoplastic and immunomodulating agents

HScode:

29335990

Categories:

Inhibitors

Characteristics

PSA:

79.4

XLogP3:

4.4

Density:

1.3±0.1 g/cm3

Melting Point:

184-187 ºC

Boiling Point:

665.7±55.0°C at 760 mmHg

Flash Point:

356.4±31.5 °C

Refractive Index:

1.663

Water Solubility:

<1 mg/mL

See More Dacomitinib Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Dacomitinib Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
api,Intermediates,Organic Chemistry,Inorganic Chemistry,Daily Chemicals,Cosmetic Raw Materals

Location:
Huangdao District, Qingdao City, Shandong Province (formerly Room 606-2, Building 1, No. 10 Beijing Road, Jiaonan City)

Payment Terms:
TT against copy of documents,D/P,D/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
15

Total Annual Revenue:
$5 million-$10 million

Total Employees:
51-100

Year of Establishment:
2023

Certifications:
Credit rating certificate,Hazardous Chemicals Business License

Company Profile
Foucsing on chemical industry,Shandong Airuike Chemical Co., LTD was established in the year 2013 and since then devoted all its efforts on how to bring best products and services to every customer,with intergrated sources and creative minds.
We are offering the market with Organic chemicals, Inorganic chemicals, Organic intermediates and water treatment products.
In construction industry,our furan resin product is high-light for metal casting as well as anticorrosion projecting for new chemical plant construction and repairing works.
Your consistent trust is our infinite power to move forward. Shandong Airuike Chemical Co., LTD never stop its step on technical researching,quality supervising,effective logistic arranging and on time services to fully satisfy customers requests. We also extended our product range by close cooperating with famous producers all around China,around the world.
By now we have established business relationship with more than 200 customers around the world.
Like our company motto says,”Innovation as power,quality as life,be honest people practical development”,Shandong Airuike Chemical Co., LTD team always put sincerity and honesty in the first place and in return customers trust us and develop win-win cooperation betwwen each other.
You’re always welcomed to contact us and share your needs,let us give you an unique satisfying for our business cooperation together.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Israel	IDO HANAN	1 G	Jun 26, 2026

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