High Quality CAS No 50-18-0 Cyclophosphamide Pharmaceutical Grade Cyclophosphamide Antineoplastic Cyclophosphamide

Cyclophosphamide (CTX) is a nitrogen mustard derivative that enters the human body and is hydrolyzed by excessive phosphatases or phosphatases present in the liver or tumors, becoming an activated type of phosphamide nitrogen mustard. The broad spectrum of anti-tumor drugs is the first so-called "latent" broad-spectrum anti-tumor drug, which is effective for both leukemia and solid tumors.
Cyclophosphamide has no activity in vitro, mainly through the hydrolysis of liver P450 enzyme to aldehyde phosphoramide, which is then transported to tissues to form phosphoramide nitrogen mustard. Cyclophosphamide can be converted from dehydrogenase to carboxyphosphamide and inactivated, or excreted in the form of acrolein, leading to urinary tract toxicity. It belongs to cyclic non-specific drugs and has the same mechanism of action as nitrogen mustard.

Function :

1. As an anti-tumor drug, it is used for malignant lymphoma, multiple myeloma, breast cancer, small cell lung cancer, ovarian cancer, neuroblastoma, retinoblastoma, Ewing's sarcoma, soft tissue sarcoma, acute leukemia and chronic lymphocytic leukemia. It is also effective for testicular tumor, head and neck squamous cell carcinoma, nasopharyngeal carcinoma, rhabdomyoma and osteosarcoma. At present, combination chemotherapy schemes are often formed with other anticancer drugs.
2. As an immunosuppressive agent, it is used in various autoimmune diseases, such as severe rheumatoid arthritis, systemic lupus erythematosus, pediatric nephrotic syndrome, multiple granulomas, pemphigus, ulcerative colitis, idiopathic thrombocytopenic purpura, etc. It is also used to resist rejection during organ transplantation, usually in combination anti lymphocyte globulin.
3. This medicine eye drop can be used for corneal ulcer caused by silkworm erosion after pterygium surgery and corneal transplantation.

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